Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
DIFFUSE CORONARY ARTERIAL ECTASIA WITH HYPERTROPHIC CARDIOMYOPATHY
141
143
EN
MOHAMMAD J.
HASHEMI
From the Cardiovascular Research Center, Shahid Rajaii Hospital, Iran University a/Medical Sciences,
Y
ALI ANDON
PETROSSIANS
N
A 40 year old male, a known case of hypertrophic cardiomyopathy, was
admitted for catheterization. At catheterization and angiography, septum was
hypertrophied to about 5cm and diffuse coronary artery aneurysm was revealed.
We found no previous report of coronary artery aneurysm in hypertrophic
cardiomyopathy.
Hypertrophic cardiomyopathy. catheterization, coronary artery aneurysm.
http://mjiri.iums.ac.ir/article-1-1447-en.html
http://mjiri.iums.ac.ir/article-1-1447-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
AC TINOMYCOSIS: AN UNUSUAL COMPLICATION OF ORAL SURGERY-A CASE REPORT
137
140
EN
MOHAMMAD HOSEIN
KALANTAR MOTAMEDI
From the Oral, Maxillofacial and Reconstructive Surgery Clinic, Baqiyalallah Medical Center, Imam Hosein University of Medical Sciences, Tehran, Islamic Republic of Iran.
Y
Actinomycosis, a rather uncommon infection of the oral cavity, poses and
unusual problem: recurrence. Primary or initial diagnosis of the disease is difficult
and can be made easier only if the clinician bears in mind a few important facts: a
previously compromised site is usually present, a slow, low-grade, almost painless
infectious course is prevalent which tends to localize, and responds to short-term
antibiotic therapy only to be followed shortly by recurrence. It is stated that with this
set of features the patient should be considered to have actinomycosis until proven
otherwise. This report presents a rather unusual case of cervicofacial actinomycosis
which occurred secondary to an attempted surgical extraction of an impacted
maxillary third molar tooth. The organism was sampled under anaerobic conditions,
identified, isolated and confirmed by Gram's stain, culture, and biochemical tests,
respectively. Cure was obtained only after surgical drainage, debridement, and oral
antibiotic administration continuing for approximately three months.
http://mjiri.iums.ac.ir/article-1-1446-en.html
http://mjiri.iums.ac.ir/article-1-1446-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
PRIMARY BILI A RY CIRRHOSIS IN A PATIENT WITH PROGRESSIVE SYSTEMIC SCLEROSIS. A CASE REPORT
133
135
EN
EJ
KUCHARZ
From the fourth , Silesian School of Medicine. Katowice. Poland.
Y
G
JONDERKO
From the fourth, Silesian School of Medicine. Katowice. Poland.
N
J
RUBISZ-BRZEZINSKA
the First Dept. of Dermatology, Silesian School of Medicine. Katowice. Poland.
N
P
BESSER
Seventh Departments of Internal Medicine Silesian School of Medicine. Katowice. Poland.
N
A 63-year-old woman suffering from progressive systemic sclerosis for about
20 years disclosed symptoms of liver disease within the last three years. Diagnosis
of biliary cirrhosis was established on the basis of clinical picture, pathological
examination of the hepatic tissue sample, immunological tests, and x-ray studies.
Association of systemic sclerosis with primary biliary cirrhosis is briefly reviewed.
Primary biliary cirrhosis, progressive systemic sclerosis
http://mjiri.iums.ac.ir/article-1-1445-en.html
http://mjiri.iums.ac.ir/article-1-1445-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
ISLAMIC MEDICAL JURISPRUDENCE PART I: GENERAL ASPEC TS AND PRINCIPLES
123
131
EN
SEYYED MOHAMMAD TAGHI
AYATOLLAHI
From Shiraz University of Medical Sciences, Shiraz, Islamic Republic of lran.
Y
Islamic medical jurisprudence, which is the subjectconcemed with the application
of Islamic laws to the area of medicine, has never been discussed as an independent
field of jurisprudence, although several selected topics, especially those concerning
food and beverages, sexuality, death, wounds and injuries, and doctor-patient
relations have been more discussed than others. The results of an investigation on the
Islamic medical jurisprudence characterized on the basis of practicing Ijtihad are
presented. A survey on the Imamate (Shiite) jurisprudence was conducted through
the works of prominent Shiite jurists from 4th- lath century to the present time. The
concept and methodology of practising Ijtihad is clarified and the authoritative
sources of the Islamic law: The Qur'an, the Sunna, the Ijma' (consensus), and the ' Aql
(reasoning) are discussed. The paper further highlights the value of human life in
Islam holding reference to the topics discussed in the Imamate works which proves
the existence of a body of medical jurisprudence that enjoys comprehensiveness,
penetration, and flexibility. In addition, the specifications of the Islamic medical
jurisprudence characterized by the organic connection between the reasoning and
divine law, negation of foreign dominance, observation of public benefit, actualization
of public responsibility, existence of flexible overriding rules, and the discretionary
authority of the jurist are elaborated. The Shiite jurists' views to medical issues prove
that pragmatism prevails and the aim is to seek a compromise between Islamic
heritage and the achievements of modern medicine, as long as basic I slamic dogma
is not violated.
http://mjiri.iums.ac.ir/article-1-1444-en.html
http://mjiri.iums.ac.ir/article-1-1444-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
THE ROLE OF NON-ADRENERGIC NON-CHOLINERGIC SYSTEM IN THE PERISTALTIC REFLEX OF GUINE A PIG ILEUM
115
122
EN
SA
NAJAFI
From the Department of Physiology, Medical School, Yazd University of Medical Sciences, Yozd, Islamic Republic of Iran.
Y
The effect of some endogenous components -endogenous opiates, cholecystokinin
(CCK), vasoactive intestinal polypeptide (VIP) and somatostatin-as inhibitory
or excitatory transmitters in the local nervous pathways involved in peristaltic
responses was examined. The peristaltic reflex was studied using a modification
of the Trendelenberg preparation. In each preparation, the luminal distension
pressure was increased in sudden steps of I cm H20 at intervals of 10, until
peristalsis was initiated. Morphine inhibited the rhythmic peristaltic activity. The
inhibitory effect of morphine was characterized by a decreased activity of both the
longitudinal and circular muscle layers. Addition of naloxone to the organ bath
reversed this inhibitory effect of morphine. Using distension pressures which
evoke only tetrodotoxin-sensitive peristaltic contractions, the mechanism rapidly
"fatigues". This fatigue can be reversed by naloxone. Higher distending pressure,
which can evoke tetrodotoxin-resistant activity, produced persistent peristalsis
with intermittent activity seize. Addition of naloxone reversed the b lockade
leading to a continuous uninterrupted peristalsis.
Proglumide ordbcGMP (selective inhibitor of the effects of CCK) increased the
threshold pressure necessary to cause the peristaltic reflex and blocked all
responses to threshold distension ..
Cholecystokinin or caerulein decreased the threshold of distension pressure
required to evoke the peristaltic reflex. Furthermore, it increased the height and
duration of the responses. The excitatory effect of CCK or caerulein was blocked
by proglumide or dbcGMP.
VIP increased the threshold of distension required to cause the peristaltic reflex
and blocked the responses to threshold distension of longitudinal but not circular
muscle layers.
Somatostatin has been proved to exert an unusual effect on peristalsis. At high
concentration it decreased the duration of the responses but had no effect on the
height of rhythmic activity. It is concluded that the activation of intramural
neurones by distension causes the release of inhibitory and excitatory transmitters,
such as endogenous opiates which interrupts peristaltic activity and CCK which
enhance the peristaltic reflex at a synapse with cholinergic neurones since CCK
releases acetylcholine from intrinsic nerves. VIP and somatostatin are involved in
the peristaltic reflex but the mechanism of their actions are not studied in this work.
http://mjiri.iums.ac.ir/article-1-1443-en.html
http://mjiri.iums.ac.ir/article-1-1443-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
INVESTIGATIONS ON THE DRUG-PROTEIN IN TERAC TION OF CERTAIN NEW POTENTIAL LOCAL ANAESTHETICS
109
114
EN
D
AL- SAADI
From the *School of Pharamacy, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of
Y
WE
SNEADER
the School of Pharmacy and Pharmacology, University of Strathclyde, Glasgow, Scotland.
N
Generally, plasma proteins owe their binding capacity to the presence of
aminoacid units which enter into intra- and intermolecular hydrophobic bonding
with a diverse range of endo- and exogenous chemical substances. The intermolecular
interactions between the hydrophobic areas of drug molecules and those of plasma
proteins play an important role in drug-macromolecular complex formation and
stabilization. This largely accounts for the carrier capacity of proteins for lipid
soluble drugs. Albumin may be particularly responsible for the binding of local
anaesthetics in plasma, but another binding factor may be lipoproteins present in
blood cell membranes. Thus, and due to the special importance of the drug-protein
binding phenomenon and its influence on the biological response, this investigation
has been commenced on the purpose of establishing whether the degree of drug-protein
interaction could be correlated with the duration of action of certain new
potential local anaesthetics. These are derivatives of 2-phenoxyethyldialkylamine
hydrochloride. Equilibrium dialysis, being generally the most reliable of the various
methods available, was chosen as a means of determining the extent of drug-protein
binding, and bovine serum albumin CBSA) of molecular weight around 70,000 was
employed. An ultraviolet assay method was used to measure the concentration of
free, unbound local anaesthetic molecules in the protein-free compartment, once
equilibrium had been attained. It was found that the affinity of the test compounds
for BSA does not parallel their duration of action produced in the guinea pig
intradermal wheal test. Moreover, the ability of BSA to bind these local anaesthetics
appeared not to depend on the number of binding sites on the protein molecule, but
rather on the proportion of :::union:::ised lipophilic species. This suggests that ionic
forces probably play no essential part in the binding process.
Local anaesthetics,equilibrium dialysis, 2-Phenoxycthyldialkylamine hydrochloride derivatives, protein binding,Procaine hydrochloride,protein binding,Bupivacaine hydrochloride,protein binding, Anaesthetics local, bovine serum albumin interaction.
http://mjiri.iums.ac.ir/article-1-1442-en.html
http://mjiri.iums.ac.ir/article-1-1442-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
A SPECIFIC, SENSITIVE, AND ONE-STEP EXTRACTION RADIOIMMUNOASSAY OF TESTOSTERONE FOR CLINICAL DIAGNOSIS
101
108
EN
GH
R ASADIKARAM
From the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, I.R.lran
Y
MJ
RASAEE
From the Department of Biochemistry, School of Medical Sciences, Tarbiat Modarres University, Tehran, I.R.lran
N
S
ALE AGHA
the Quality.Control Department, Razi Research Institute, Karaj, I.R. Iran
N
GL
KUMARI
the Department of Reproductive Biomedicine, National Institute of health and Family Welfare,New Delhi, India
N
PN
RAO
the Department of Organic Chemistry. South West Foundation of Biomedical Research, San Antonio, Texas, USA.
N
Testosterone was measured using antibodies raised against testosterone II B-carboxymethyl
ether bovine serum albmin (T-IIB-CME-BSA) and testosterone 3-
O-carboxymethyl oxime-BSA as immunogen. The antibody produced in this study
exhibits minimal cross reactivity with the structurally related steroids specially 5
dihydrotestosterone (5 DHD. This allows to ommit the clean up step and measure
testosterone in female serum samples accurately with a high sensitivity, precision,
and specificity. The coefficent of variation (CY), standard deviation (SD) and
standard error of mean (SE) were all in acceptable ranges. Antibody-bound and free
steroids were separated by addition of dextran coated charcoal. The method was
applied to a set of clinical samples, the results of which are discussed in this
communication. The assay was compared with the available imported kits using 125
I as tracer. The correlation coefficient obtained is calcualted to be r= 0.96, showing
that the results obtained by these two methods are fully comparable and the assay may
be replaced with the similar preparations imported from abroad.
http://mjiri.iums.ac.ir/article-1-1441-en.html
http://mjiri.iums.ac.ir/article-1-1441-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
CIMETIDINE CAN MODIFY THE EFFECTS OF WHOLE BODY \'Y-IRRADIATION ON LY MPHOHEM ATOPOIETIC SYSTEM
95
99
EN
HOSSEIN
MOZDARANI
From the School of Medical Sciences, Tarbiat Modarres University, P.O .Box 14155-4838, Tehran, IslamicRepublic of Iran.
Y
NAGHl
J. VESSAL
N
The hematopoietic syndrome is anticipated when a dose of radiation greater than
100 cGy is received. The resulting clinical situation is life-threatening because of
opportunistic infections and gradual decline in immune competency due to irradiation.
Because of evidence of a possible immunomodulatory role for cimetidine, an
antagonist of histamine H2 receptors, we studied the effects of this drug on radiationinduced
lymphohematopoietic changes. The results obtained in this study indicate
that cimetidine is effective in the reduction of radiation-induced injuries with a dose
reduction factor of greater than 1.5. Therefore, it might be useful as a radioprotector
for low doses of radiation usually used for radiation therapy.
http://mjiri.iums.ac.ir/article-1-1440-en.html
http://mjiri.iums.ac.ir/article-1-1440-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
HOW ALUMINIUM IS TAKEN U P BY RED BLOOD CELLS: A STUD Y IN RELATION TO H YP OCHROMIC MICROC YTIC ANEMIA IN HEMODIALYZED PATIENTS
87
93
EN
AA
MOSHTAGHIE
From the Dept of Biochemistry. School of Pharmacy, Isfahan University of Medical Sciences. Isfahan, Islamic Republic of Iran.
Y
Investigation of aluminium uptake by human erythrocytes was the major aim of
this study. Packed red blood cells were incubated in Earle's medium (pH 7.4)
containing varying concentrations of aluminium (0-160 /lg/J) as AIK(SO.), and
aluminium content of the cells were determined using flameless atomic absorption.
There was significant increase in aluminium content of the cells. Addition of 5 mM
glucose caused an elevation of red cell aluminium, whereas depletion of red cells
from ATP caused a marked reduction in aluminium uptake. Both ouabain and
vanadate, when added to the medium, caused a significant reduction in aluminium
uptake in line with a decrease in ATPase activity.
http://mjiri.iums.ac.ir/article-1-1439-en.html
http://mjiri.iums.ac.ir/article-1-1439-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
THE EFFECT OF NOISE-INDUCED HEARING LOSS ON DENTISTS
83
86
EN
PARVIN
NASSIRI
From the Department of Occupational Health, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran
Y
FARIDEH
GOLBABAI
N
MAHMOUD
MAHMOUDI
N
This paper presents noise problems associated with the use of air-turbine drills
in dental practice. Two hundred and fifty dentists (male and female) were randomly
selected from the faculty of dentistry as well as the dentists who worked private in
Tehran. The results indicated that the mean value of sound pressure level produced
by the high-speed drills was 69.1 db. Most of the energy from the drills lied in the high
frequency range, 6000- 8000 Hertz. Audiological evaluations showed that the loss
of hearing in all age groups and years in dental practice lie in 6000 Hertz which has
a positive correlation with the value of sound pressure level in this frequency. The
hearing loss in the right ear of women was slightly higher than the left one, while this
was not true in men. The hearing loss in the female group was greater than in male
group.
Dentists, air-turbine drills, noise, hearing loss, audiometry
http://mjiri.iums.ac.ir/article-1-1438-en.html
http://mjiri.iums.ac.ir/article-1-1438-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
INFECTIVE ENDOCARDITIS: A lO-YEAR STUDY IN SHIRAZ UNIVERSITY HOSPITALS
77
82
EN
NASROLLAH
GHAHRAMANI
From the Dept. of Medicine Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
Y
ALI M.
HANDJANI
From the Dept. of Cardiology Section, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
N
The medical records of all patients discharged with the diagnosis of "infective
endocarditis", "subacute bacterial endocarditis (SBE)," "acute bacterial endocarditis
(ABE)," and "bacterial endocarditis" from March 1977, to February 1987, were
reviewed. 84 cases fulfilled the criteria of endocarditis. Sixty-one percent were male
and the mean age was 25.7 years. 57% were culture-negative and among culturepositive
cases, S. aureus was predominant (44%). Culture-positivity was associated
with higher mortality. Multiple valve involvement was most common (36%).
Among fatal cases, mitral involvement was most common (33%) and mitral
involvement was associated with the highest mortality (22%). 92% of the patients
showed evidence of abnormal heart before development of endocarditis, rheumatic
heart disease being the most common (73%). The mortality rate was 21 % and CNS
complications were the major cause of death. Although much of our results are
consistent with published data, there are some major differences. Points which might
explain these differences are: high incidence of rheumatic heart disease among
Iranians, delay in seeking medical care, indiscriminate use of antibiotics prior to
adequate cultures, and shortcomings in laboratory techniques.
http://mjiri.iums.ac.ir/article-1-1437-en.html
http://mjiri.iums.ac.ir/article-1-1437-en.pdf
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
2251-6840
7
2
1993
8
1
CONGESTIVE HEART FAILURE IN CHILDREN: A SURVEY OF 114 PATIENTS
73
76
EN
SHAHLA
ROODPEYMA
From the Department of Pediatrics. Taleghani Medical Center, Shaheed Beheshti University of Medical Sciences. Tehran. Islamic Republic of Iran.
Y
During a period of four years between June, IS, 1988 to June, IS, 1992 one
hundred and fourteen patients with congestive heart failure (CHF) were admitted to
the pediatric department of Taleghani General Hospital. During the above period,
192 patients with heart disease were hospitalized at this department and CHF was the
cause of admission in 59.4% of them. Congenital heart disease (CHO) was the most
common cause (65 cases, 57%) of heart failure in this group, followed by rheumatic
heart disease (RHO) (26 cases, 23%) and cardiomyopathy (CM) (23 cases, 20%).
Sixty-five patients (57%) were male and forty-nine (43%) were female (M/F = 1.3/
I). The youngest patient was 2 days old while the oldest one had 13 years. The mean
age of the patients was 4.5 years. Forty-nine (43%) were under one year of age and
the majority (44/49, 90%) suffered from CHO. All the children with RHO were
between 6 to 13 years of age. 14 patients (12%) died. CHO was the most common
cause of death. The variations in the pattern of heart failure according to different age
groups in this study are compatible with those in other developing countries.
Congestive heart failure, Congenital heart disease. Rheumatic heart disease, Cardiomyopathy
http://mjiri.iums.ac.ir/article-1-1436-en.html
http://mjiri.iums.ac.ir/article-1-1436-en.pdf