Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
EFFECT OF IODINE DEFICIENCY ON I.Q.LEVELS OF APPARENTLY NORMAL INHABITANTS OF AN ENDEMIC GOITER AREA
337
337
EN
A
IZADPANAH
Dept. of General Surgery. Shiraz Univ of Med. Sciences
A
LAMBE
Dept of Medicine. Urumieh Univ. of Med. Sciences.
K
NIK-EQBAL
Shoorideh School for the Mentally Retarded
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
MOLECULAR BIOLOGY OF HUMAN IMMUNODEFICIENCY VIRUSES: HIV-l AND HIV-2
321
336
EN
FATAH
KASHANCHI
From the Laboratory of Molecular Virology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
M. REZA
SADAIE
the Laboratory of Immunochemistry, Division of Transfusion-Transmitted Diseases, Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, MD 20852, USA.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
XANTHOMA WITH OCULAR AND CARDIOVASCULAR INVOLVEMENT IN A BOY
317
319
EN
S
SHAMSADINI
From the Department of Dermatology , Kerman Darman Hospital, Kerman, Islamic Republic of Iran.
M
MOAZENZADEH
From the Department of Cardiology Kerman Darman Hospital, Kerman, Islamic Republic of Iran.
S
DABIRI
From the Department of Pathology and Ophthalmology, Kerman Darman Hospital, Kerman, Islamic Republic of Iran.
M
MESHKAT
From the Department of Dermatology , Kerman Darman Hospital, Kerman, Islamic Republic of Iran.
In this report, a 10 year old boy with both tendinous and tuberous xanthoma
is presented. Premature corneal arcus and aortic stensosis were associated findings
in this case. Tuberous and tendinous xanthomas are two clinical varieties of one
disease, both of which are seen in type II hyperlipoproteinemia. Increased serum
cholesterol with pathological findings of skin lesions with oculocardiac involvement
are all in favour of a homozygous condition. This is a rare disorder, and
occurs in one per million of the general population, but a combination of two kinds
of clinical skin lesions with cardiac involvement and corneal arcus is very rare.
Therapy with cholestyramine 2 grams daily orally was prescribed. After six
months of therapy, there was no improvement in his problem
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
ACNE FULMINANS ASSOCIATED WITH REACTIVE POLYARTHRITIS: REPORT OF A CASE AND REVIEW OF THE LITERATURE
313
316
EN
A
A. RAJAEE
From the Department of Medicine, Division of Rheumatology, and the Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
M
SODEIFI
We describe a 16 year old boy with acne fulminans associated with axial and
peripheral polyarthritis. The patient's clinical course and therapy with isotretinoin,
prednisolone and oxytetracycline are described. A possible association between
the presence of HLA -B 27 antigen and reactive arthritis with acne fulminans in this
case is evaluated. A review of the literature is included.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
PRIMARY DIFFUSE LYMPHOMATOUS POLYPOSIS OF THE GASTROINT ESTINAL TRACT
309
311
EN
H
FOROUTAN
From the GI Endoscopic Section. Imam Khomeini Hospital. Tehran University of Medical Sciences. Tehran. Islamic Republic of Iran
SA
MORTAZAVI
A rare case of diffuse lymphomatous polyposis of the gastrointestinal tract is
reported in which the patient presented with abdominal pain, weight loss and
bloody diarrhea. X-rays revealed multiple polyps involving the stomach, small
intestine and colon. Biopsies confirmed the diagnosis of lymphomatous polyposis.
The duration of symptoms and signs was 3 months. Diffuse lymphomatous
polyposis of the gastrointestinal tract is a distinct entity, separated from diffuse
gastrointestinal lymphoma or Mediterranean-type lymphoma
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
SYMPTOMATIC RATHKE'S CLEFT CYST: A CASE REPORT
305
307
EN
AHMAD
KAMGAR POUR
From the Department of Neurosurgery, Beheshti Hospital, Shiraz University of Medical Sciences, Shiraz
SEYYED ALI
FAKHR TABATABAI
the Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A large Rathke's cyst was marsupialized into the sphenoid sinus of a 45-year
old woman who presented with headache, polydipsia, cessation of menses and
diplopia. A brief review of cases is presented.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
NOVEL REAGENTS FOR CREATINE KINASE
299
304
EN
MAHMOUD
AMINLARI
From the Department of Biochemistry, School of Veterinary Medicine
HABIB
FIROOZABADI
the Department of Chemistry, Shiraz University, Shiraz, Islamic Republic of Iran.
ORLI
SIMOZAR
the Department of Chemistry, Shiraz University, Shiraz, Islamic Republic of Iran.
The purpose of this investigation was to develop a simple colorimetric
method for creatine kinase (CK). The new method is based on the reaction of
creatine, formed enzymatically from creatine phosphate and ADP, with different
glyoxal compounds. Hydrated glyoxals, such as para-nitrophenyl, 2-thiophene, 4-
biphenyl, 4, 4' -biphenyl,α-naphthyl, β-naphthyl, para-chlorophenyl, and styryl
were synthesized and allowed to react with creatine. Among the glyoxals, the 2-
thiophene derivative was the best in terms of the stability and intensity of the
colored complex which was produced under mild alkaline conditions. The
complex absorbed maximally at 460 nm with an extinction coefficient of 1.56x 1 04
M-I Cm-I. This reagent was used to determine CK in the sera of normal human
beings and patients with myocardial infarction. The results obtained were in
agreement with those obtained by another available method for CK. However, this
new method is simple, less time consuming and employs a single reagent for color
development. Such a simple method might be of value in clinical laboratories with
little access to sophisticated instruments such as auto analyzers and spectrophotometers
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
PURIFICATION AND CHARACTERIZATION OF PROTEIN ANTIGENS ISOLATED FROM MYCOBACTERIUM TUBERCULOSIS (H37Rv STRA IN) AND THEIR EFFECTS ON CELL-MEDIATED IMMUNE RESPONSES IN GUINEA PIGS
291
297
EN
A
ZAVARAN HOSSEINI
From the Department of Immunology, Tarbiat Modarres University
MB
ESLAMI
the Dept. of Immunology School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
M
JALALI
the Dept. of Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Mycobacterium tuberculosis (H37Rv strain) was used in this study. The
bacterial cells were disintegrated by sonication. The separation and characterization
of the soluble molecules were attempted by various techniques including gel
filtration, ion exchange chromatographies and polyacrylamide gel electrophoresis,
using SDS and 2ME. Eight protein molecules with molecular weights ranging
from 6.3 up to 204 kD were identified. Following reduction of the 204 kD molecule
with 2ME, six smaller molecules with 12a, 12b, 21, 29,45 and 81.5 kD molecular
weights were obtained.
All isolated protein molecules were able to induce delayed hypersensitivity
skin reaction in sensitized guinea pigs and proliferation of T-cells in vitro.
Regarding the fact that an effective protective immunity in tuberculosis is
dependent mainly on T-cell response, it is suggested that the molecules isolated in
this study may be useful in conceiving a vaccine and/or diagnostic tests for
tuberculosis.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
EFFECTS OF SERUM AND PROTEIN SYNTHESIS INHIBITORS ON POLYMORPHONUCLEAR NEUTROPHIL APOPTOSIS
285
289
EN
TAHEREH
ZIA FAZELI
From the Institute of Biochemistry and Biophysics, University of Tehran, P.O. Box 13145-1384, Tehran, Islamic Republic of Iran.
AZRA
RABBANI
In this study the programmed cell death (apoptosis) of human neutrophilic
granulocytes was investigated in the presence and absence of fetal calf serum (FCS),
cycloheximide and actinomycin-D. The results show that when FCS is omitted from
cultures, apart from a decrease in viability, the percentage of apoptotic cells and DNA
fragmentation increases. Apoptosis is accelerated in serum withdrawal cultures at 6
hours of incubation time. The use of fluorescent dyes and diphenylamine reaction
proceaures confirm the above results. Treatment of cells with protein synthesis
inhibitors, actinomycin-D and cycloheximide promotes apoptosis and produces a
typical ladder of internucleosomal cleavage in the cellular chromatin the extent of
fragmentation however, differs.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
INVOLVEMENT OF SUPRASPINAL ALPHAADRENERGIC RECEPTORS IN TONIC PAIN
279
284
EN
S
SEMNANIAN
From the Department of Physiology, Shaheed Beheshti University of Medical Sciences
S
HAJISAYAH
the Department of Physiology, Tarbiat Modarres University
MR
ZARRINDAST
the Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
The involvement of supraspinal alpha-adrenergic receptors in tonic pain was
assessed in formalin-induced pain in rats. The alpha2 adrenoceptor agonist
clonidine, along with yohimbine and prazosin, α2 and α1 receptor antagonists,
were introduced intracerebroventrically (icv) and/or systemically in different
doses. The data show that 1) clonidine exerts an alpha adrenergic analgesic effect,
in addition to its known alpha2 role in this kind of pain, 2) icv yohimbine did not
change the rat's nociception, and 3) icy prazocin also failed to alleviate the animal's
nociception although both the latter drugs show analgesic activity in the formalin
test when injected systemically. It can be concluded that α1 receptors contribute
significantly to adrenergic analgesia in the formalin test in supraspinal structures,
by undefined nature and site(s).
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
PRIMARY TORSION AND IDIOPATHIC SEGMENTAL INFARCTION OF OMENTUM
271
278
EN
MRK
MOTAMEDI
From the Department of Surgery, Shohada Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran.
MR
ZAFARGHANDI
MHS
MODAGHEGH
Torsion and infarction of the greater omentum are two rare clinical situations
which present as an acute abdomen. Nevertheless, knowledge concerning these
two problems can help the surgeon in proper diagnosis and treatment. Since the
first report on primary torsion by Eitel in 1899, a few hundred more have been
reported and some collective reviews published to date. In this study we will
present a complete review concerning the history, classification, pathophysiology,
clinical manifestations and treatment of these disorders. In addition, we will report
seven cases, four of whom developed primary torsion and the other three
idiopathic segmental infarction of the omentum.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
A STUDY ON GIARDIASIS IN PREGNANCY
267
269
EN
A
A. DALIMI
From the Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modarres University, P.O. Box 14i55-4838, Tehran, Islamic Republic of Iran
F
GHAFARI FAR
In this study 404 pregnant women in Islamshahr, a district southwest of
Tehran, were examined for giardiasis. Results showed 7.92% of them to be
positive. Abdominal pain, nausea and diarrhea were observed as the most common
symptoms in infected mothers. Results also indicated that hematological parameters
and weight gain of infected pregnant women did not differ significantly from
those without any parasitic infection. Also, birth weight, length and head
circumference of the neonates of these two groups of mothers did not show any
significant difference.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
DETERMINATION OF SERUM LIPOPROTEINS IN BETA-THALASSEMIA TRAIT AND THEIR RELATIONSHIP TO CHRONIC HEMOLYSIS
263
265
EN
M
PEDRAM
From the Department of Hematology and Oncology, Shafa Hospital, Ahwaz University of Medical Sciences
KM
ZANDIAN
B
KEYKHAII
SAH
JAHANMEHR
MR
MOHEGH
Dept. of Laboratory Sciences, Ahwaz, Islamic Republic of Iran
100 patients with beta-thalassemia trait, comprised of 55 men and 45 women,
participated in a study to measure serum lipoproteins. The results were compared
with the data obtained from 100 control subjects of the same age and sex. A
significantly lower level of mean serum total cholesterol and LDL cholesterol, and
a much higher level of HDL cholesterol were obtained in beta-thalassemia trait as
compared to control groups. This study was carried out in order to find the effect
of mild hemolysis on serum lipid composition.
Iran University of Medical Sciences
Medical Journal of The Islamic Republic of Iran (MJIRI)
1016-1430
10
4
1997
2
1
SHORT TERM CLINICAL OUTCOME OF PERCUTANEOUS BALLOON MITRAL VALVULOPLASTY VERSUS SURGICAL CLOSED MITRAL COMMISSUROTOMY
259
262
EN
M
MOMTAHEN
From the Shahid Rajai Cardiovascular Cerner, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran.
A
MOHEBBI
M
KIAVAR
MB
TABATABAIE
BaIlon mitral valvuloplasty and closed mitral valve conunissurotomy were
performed in 450 and 127 patients, respectively. Also, 254 patients with severe
mitral stenosis were enrolled in a prospective randomized trial comparing the two
procedures.
Immediately after balloon mitral valvuloplasty, mean left atrial pressure was
11.38±3.54 mmHg, transmitral valve gradient was 1.8±2 mmHg, and mitral valve
area was 204± 004 cm2 (allp< 0.0001). At one week follow up after surgical mitral
commissurotomy, transmitral valve gradient was 604±2o4 mmHg and mitral valve
area was 1.85±Oo45 cm2. Two cases of severe mitral regurgitation occurred in each
group. There was one case of death due to infection in the surgical commissurotomy
group. Mild to moderate mitral regurgitation occurred in 36 patients (28.3%) in the
surgical commissurotomy group whereas 11 patients (8.7%) developed only mild
mitral regurgitation in the balloon commissurotomy group. The success rate was
96.8% in each group. We conclude that immediate hemodynamic results of
balloon mitral commissurotomy, if not superior, is as favorable as surgical
commissurotomy and is the treatment of choice in selected cases.