2024-03-29T05:33:34+04:30 http://mjiri.iums.ac.ir/browse.php?mag_id=38&slc_lang=en&sid=1
38-694 2024-03-29 10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 FAMILIAL COLLOID CYST OF THE THIRD VENTRICLE: A CASE REPORT AND REVIEW OF THE LITERATURE SOHRAB SADEGHI GUIVE SHARIFI guivesharifi@hotmail.com ALI ALIASGARI Familial colloid cyst of the third ventricle is very rare. This is one of the two largest families reported and the first in which all affected members are siblings. One asymptomatic sister was found by screening, emphasizing the value of screening. A brother and two sisters from a family consisting of three brothers and three sisters who were diagnosed as having colloid cyst of the third ventricle are presented. The index case like his sister underwent a tumor resection by middle frontal gyrus approach. Brain CT scan was performed for the other first degree family members for screening and colloid cyst was detected in another sister_ When two or more members of a family are affected, screening has an important value for detecting other asymptomatic members with colloid cyst of the third ventricle. colloid cyst third ventricle familial. 2003 11 01 267 269 http://mjiri.iums.ac.ir/article-1-694-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 ACUTE APPENDICITIS DUE TO METASTASIS OF PROSTATIC CARCINOMA B ARYA B GHAZI-MOGHADAM MJ GOOLALIPOUR R AZARHOOSH A 70 year old male presented with right lower quadrant pain and anorexia for about 72 hours prior to hospital admission. He underwent laparotomy with impression of acute appendicitis. The operative finding was an inflamed tumoral appendix without appendicular base involvement, and appendectomy was done. The patient had an uneventful post-op course. Due to the pathology report of prostatic carcinoma he underwent cystoscopy and biopsy of prostate on the 4th post-op day. Histopathology of the appendix was consistent with metastatic adenocarcinoma of the appendix with prostatic origin. Histopathology of the prostatic specimen was consistent with high grade prostatic adenocarcinoma. Appendix Adenocarcinoma Prostate. 2003 11 01 263 265 http://mjiri.iums.ac.ir/article-1-692-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 INVESTIGATION ON ANTI-GLUTAMIC ACID DECARBOXYLASE ANTIBODIES IN TYPE I DIABE TES MELLITUS M MESSRIPOUR m_messripour@yahoo.com M HARATY Antibodies directed against the enzyme glutamic acid decarboxylase (GAD) are believed to be the main cause of destruction of pancreatic islet cells in type I (insulin dependent) diabetes mellitus. The enzyme was found both in the brain and pancreatic beta cells. Although similarities in identity of GAD in human and rat brain have been demonstrated, little is known about the interaction between the enzyme and antiserum in type 1 diabetic patients. In the present study GAD was partially purified from rat brain homogenate. The four-step procedure involves, sequentially, an ultracentrifugation, DEAE-cellulose, hydroxyapatite resin, and Sephadex G-200 gel filtration chromatography. The enzyme activity was assayed either manometrically or fluorimetrically. The results showed a positive correlation between the rates of CO2 production with the changes of fluorescence intensities of the enzyme after addition of glutamate. The collected fraction from the gel filtration chromatography showed approximately 140-fold purification of the enzyme with a 15% yield. The specific activity of the enzyme of brain supernatant and the partially purified enzyme collected from every chromatographic step was measured upon addition of the serum samples from type I diabetes (n=II). A marked decrease in the rate of CO2 production or the change of fluorescence intensities of the enzyme was observed, indicating an interaction between the enzyme and the patients' sera. However, serum samples from healthy control individuals had little effect on the enzyme activity of the partially purified GAD. The results suggested that rat brain GAD might be used as an in vitro reagent for screening of type I diabetes, using an enzyme inhibition assay. Glutamic acid decarboxylase Anti-GAD antibodies Type I diabetes mellitus Neuroendocrinology Enzyme inhibition assay. 2003 11 01 259 262 http://mjiri.iums.ac.ir/article-1-691-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 COMPARISON OF ACUTE AND CHRONIC EFFECTS OF NIFEDIPINE ON NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN MICE M RABBANI rabanim@yahoo.com A JAFARIAN-DEHKORDI MH SOBHANIAN Mice were rendered tolerant and dependent to morphine by subcutaneous injection of morphine over a period of 5 days. The effects of acute and chronic administration of dihydropyridine calcium channel antagonist nifedipine on the development of tolerance and naloxone-precipitated morphine withdrawal signs were investigated. A single injection of nifedipine proved to be effective in inhibiting some signs of morphine withdrawal but ineffective in blocking the development of tolerance to the ataxic action of morphine. The concurrent injections of nifedipine with morphine prevented most signs of morphine withdrawal but failed to have any effects on the development of tolerance to the ataxic action of morphine. The results suggest that alterations in dihydropyridine-sensitive calcium channels may be involved in the adaptations that occur on chronic treatment with morphine. It is also possible to conclude that separate mechanisms are involved in the development of tolerance and dependence. Nifedipine; morphine withdrawal; tolerance. 2003 11 01 251 257 http://mjiri.iums.ac.ir/article-1-690-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 MAKING AN EXPERIMENTAL ANIMAL MODEL FOR MULTIPLE SCLEROSIS F ALASTI MH SANATI msanati@nrcgeb.ac.ir To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptible animals, was used. Proteolipid protein (PLP) , which is a prominent neuroantigen, was extracted from fresh bovine brain, and used for inducing EAE in female Balb/c and Guinea pig. Animals were weighed and examined daily for clinical symptoms. Also histological sections from EAE brains were prepared. These sections showed infiltration, congestion and demyelination. Multiple Sclerosis disease EAE animal model PLP. 2003 11 01 245 249 http://mjiri.iums.ac.ir/article-1-689-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 COMPARISON OF PCR BASED ASSAY AND CELL CULTURE IN DETECTION OF UROGENITA L CHLAMYDIA TRACHOMATIS INFECTION AND DETERMINATION OF THE INHIBITORY RATE O F SPECIMENS UNDER STUDY M NASROLAHEI M SHARIF HG ROBSON An amplification polymerase chain reaction (PCR) test for the direct detection of Chlamydia trachomatis in urethral and endocervical swab specimens from symptomatic and asymptomatic women and men were compared to standard culture technique. During 6 months, 300 endocervical swab specimens from 205 asymptomatic women (64.4%) and 95 symptomatic women (31.6%), and 187 urethral swab specimens from 79 asymptomatic men (42.3%) and 108 symptomatic men (57.7%) attending the Gynecology Dept. and Genitourinary Clinic of Royal Victoria Hospital, Montreal, were collected. Processed specimens were cultured in McCoy cells and PCR was performed in a tube containing primer for C. trachomatis and internal control (IC). PCR products were detected by colorimetric and hybridization assay. Discrepant analysis for any specimens without unanimous results were performed by direct fluorescent antibody (DFA) or major outer membrane gene test (MOMP) with the 2SP medium sediment. In this study culture detected 13.1 % of asymptomatic and 33.6% of symptomatic infected women. By PCR, 16% of asymptomatic and 45.2% of symptomatic infected women exhibited positive results. By culture, 36.6% of asymptomatic and 45.3% of symptomatic men were positive, whereas 50.6% of asymptomatic and 51.8% of symptomatic men were positive by PCR. Sensitivity and specificity of PCR for asymptomatic and symptomatic women were 82.5% and 99.3%, and 89.5% and 97.8% respectively. Sensitivity and specificity of PCR for asymptomatic and symptomatic men were 93% and 100%, and 93.3% and 97.9% respectively. Sensitivity and specificity of culture for asymptomatic and symptomatic women and men were 67.5% and 100%, 66.6% and 100%,67.4% and 81.6%, and 100% and 100% respectively. The overall sensitivity and specificity of PCR and culture were 90% and 98%, and 75.6% and 100%. The internal control revealed that 3.9% of specimens were inhibitory, but when an aliquot of 10 fold dilution of these specimens was retested, 73.6% of them were non-inhibitory. In this study PCR exhibited higher sensitivity than culture for detection of C. trachomatis in both endocervical and urethral swab specimens and can be recommended for use in the c1inical laboratory. Chlamydia trachomatis polymerase chain reaction endocervical specimens. 2003 11 01 239 244 http://mjiri.iums.ac.ir/article-1-688-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 A PROSPECTIVE, RANDOMIZED, CONTROLLED TRIAL OF HIGH AND LOW DOSES OF MAGNESIUM SULFATE FOR ACUTE TOCOLYSIS VIDA BEHRAD v_behrad@yaboo.com NEZHAT MOOSAVIFAR MOJTABA MOJTAHEDZADEH HABID-OLLAH ESMAILI PARISSA MOGHTADAII At the present, many drugs are used for inhibition of uterine contractions, but the proportions of preterm labors are increasing. Although magnesium sulfate is the most commonly prescribed parenteral tocolytic agent, but its optimal use has yet to be delineated. In this study a high-dose protocol for magnesium sulfate tocolytic therapy was compared with a low-dose regimen. One-hundred patients admitted to the labor unit of Imam Reza's hospital with preterm labor were enrolled in the trial. The median times to successful tocolysis were 8 hours in the low-dose group and 4 hours in the high-dose group (p<0.001). Patients treated with higher doses were also more likely to spend significantly less time in the labor and delivery unit (p<0.001). The median gestational age at delivery was 33 weeks in the low-dose group and 36 weeks in the high-dose group (p=O.OO l). There were not any statistically significant differences between the two groups with respect to pre- and post magnesium infusion side effects. These results suggest that in the high-dose group, tocolysis was achieved more rapidly and patients required shorter admissions to the labor and delivery unit without increased maternal or neonatal morbidity. Magnesium sulfate Tocolysis Tocolytic agent Preterm labor Preterm birth. 2003 11 01 233 238 http://mjiri.iums.ac.ir/article-1-687-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 MORPHINE RELE ASES GLUTAMATE THROUGH AMPA RECEPTORS IN THE VENTRAL TEGMENTAL AREA: A MICRODIALYSIS STUDY IN CONSCIOUS RATS H ALAEI alaei@med.mui.ac.ir M HUOTARI PT PIEPPONEN L AHTEE O HANNINEN PT MANNISTO In vivo microdialysis was used to study the effects of morphine on glutamate release from the ventral tegmentum area (VTA) in freely moving rats. Intraperitoneal (i.p.) injection of acute and repeated morphine at increasing doses significantly enhanced glutamate release. Only a minor tolerance developed to this dosage of morphine. AP-S (2-amino-5-phosphonovaleric acid, 0.5 mg/kg i.p.), a NMDA receptor antagonist, given 20 min before each repeated morphine injection, did not have a significant effect on the stimulated glutamate release . Conversely, injection of CNQX (6-cyano-7-nitroquinoxaline-2, 3-dione, 0.5 mg/kg i.p.), an AMPA receptor antagonist, 20 min before each morphine dose was found to markedly inhibit morphine-induced glutamate release in the VTA. In all experiments, glutamate release reduced by time. These results show for the first time that acute and repeated injection of morphine stimulates glutamate release in the conscious rat VTA via AMPA receptors. Morphine Glutamate V TA Microdialysis. 2003 11 01 225 231 http://mjiri.iums.ac.ir/article-1-686-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 EXPRESSION OF NONSTRUCTURAL GLYCOPROTEIN NSP4 OF SAIl SIMIAN ROTAV IRUS IN ESCHERICHIA COLI AND PRODUCTION OF ANTIBODY AGAINST IT Z SHARIFI B YAKHCHALI byakhcha@nrcgeb.ac.ir MS SHAHRABADI Rotavirus nonstructural glycoprotein NSP4 can induce diarrhea in newborn mice. It has been suggested that NSP4 may be a key determinant for rotavirus pathogenesis and a target for vaccine development. In order to study the biological and morphological role of NSP4 a large amount of the purified protein and antibody against it are required. Simian rotavirus SA11 was propagated in BSCl cell, purified on cesium chloride gradients, and its genomic RNA was extracted. A cDNA from RNA segment 10 was synthesized and amplified by RT-PCR. cDNA fragment was cloned into plasmid vectors. The recombinant plasmid was characterized by restriction enzyme and sequencing. Construction of expression plasmid containing nsp4 gene was performed and expression of NSP4 was demonstrated by SDSPAGE, Western blot, ELISA and IF using polyclonal antibody against NSP4 from SA11 infected BSCI cells. A polyclonal antiserum against purified recombinant NSP4 was raised in rabbit which was reacted with NSP4 in BSCI cells infected with SA11 rotavirus. These results indicated successful expression of the full-length NSP4 in E.coli to produce antibody against it and to study its biological activities. Expression NSP4 Rotavirus E.coli. 2003 11 01 217 224 http://mjiri.iums.ac.ir/article-1-685-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 DOES CIGARETTE SMOKING AFFECT MUSCLE FLAP SURVIVAL? AN 8 YE AR EXPERIENCE OVER 261 CONSECUTIVE C ASES IN SOUTHERN IRAN HA NIKPOUR Smoking has been shown to be a complicating factor in normal wound healing. Both nicotine and carbon monoxide adversely affect multiple stages of the healing process. From 1991 to 1999,407 muscle flap procedures were performed on 374 patients in a single surgical unit. A retrospective review of 261 patients was completed. Patients were divided into three groups: Group A, no smoking history group B, smokers for at least one year, and group C, active smokers up to the time of surgery. Patients were excluded who had diabetes, had a recurrent malignancy, or used steroids. A total of 261 patients were included in the study. The age, sex, number of patients and primary operative indications were matched in the 3 groups. Active smokers were shown to have a complication rate significantly higher in the immediate post-operative period compared with non-smokers and smokers who had quit. The most common complications were partial muscle necrosis and partial skin graft loss. This series suggests that active smoking at the time of muscle transposition significantly increases the rate of postoperative complications. Cigarettes smoking muscle flap. 2003 11 01 213 216 http://mjiri.iums.ac.ir/article-1-684-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 CAUSES OF INTRACTABLE SEIZURES IN A SURVEY OF 10,000 EPILEPTIC CHILDREN A A. NASIRIAN Although treated properly for epilepsy, a number of epileptic children have intractable seizures and about 5-10 per cent of them do not respond to anti -epileptic drugs. In the years 1986-1996 about 10,000 epileptic patients were treated in the Children's Medical Center in Tehran. A retrospective study of their medical records revealed that 41 of them had intractable seizures. I Of these 41 patients, 56.9% had partial epilepsy, 12.2% grand mal epilepsy, 14 % atypical petit-mal, 7.3% Lennox syndrome, 7.3% infantile spasm and 2.4% myoclonic epilepsy. All of them had received at least two anti-epileptic drugs. 34.1 % were not treated regularly. 31.7% had organic brain dysfunction and 51.6% had behavior disorder (hyperactivity-aggressiveness, etc.). These figures show a lower rate of intractable seizures than that of international statistics. T he most important cause of intractable seizures seems to be irregular treatment of the epilepsy. Epilepsy Intractable seizures Irregular treatment. 2003 11 01 209 212 http://mjiri.iums.ac.ir/article-1-683-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 A PROSPECTIV E, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED CLINICAL TRIAL OF DEXAMETHASONE DURING THE FOLLICULAR PHASE IN CLOMIPHENE RESISTANT PATIENTS WITH POLYCYSTIC OVARY SYNDROME AND NORMAL DHEAS ME PARSANEZHAD parsame@sums.ac.ir M RAOOFI S ALBORZI GH OMRANI In order to evaluate the effects of short course administration of dexamethasone (DEX) combined with clomiphene citrate (CC) in CC-resistant patients with polycystic ovary syndrome (PCaS) and normal DHEAS, a prospective, double blind, placebo controlled, randomized study was undertaken at referral university hospitals, Two-hundred and thirty women with PCOS and normal DHEAS who failed to ovulate with a routine protocol of CC received 200 mg of CC from day 5 to 9 and 2 mg of DEX from day 5 to 14 of the menstrual cycle. The control group received the same protocol of CC combined with placebo. Follicular development, hormonal status, ovulation rate, and pregnancy rate were evaluated. Mean follicular diameters were 18.4124±2.4314 mm and 13.8585±2.0722 mm (p<0.001) for treatment and placebo group respectively. Eighty-eight percent of treatment and 20% of the control group had evidence of ovulation. The difference of cumulative pregnancy rate in treatment and control groups was statistically significant (p<0.000l). Hormonal levels, follicular development and cumulative pregnancy rate improved with the addition of DEX to CC in CC-resistant patients with PCOS and normal DHEAS.This regimen is recommended before any gonadotropin therapy or surgical intervention. Polycystic ovary DHEAS clomiphene citrate dexamethasone. 2003 11 01 203 207 http://mjiri.iums.ac.ir/article-1-682-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 THE VALUE OF PONDERAL INDEX AS A PROGNOSTIC FACTOR IN PREDICTING COMPLICATIONS IN TERM NEONATES FIROUZEH NILI F_nili2000@yahoo.com MARJAN MAKIPOUR JAMILEH MOBINI Rohrer's ponderal index in newborns (birth weight * 100/height3) has been used as an indicator of fetal growth status, especially to assess asymmetrical intrauterine growth retardation. Low ponderal index or disproportionate intrauterine growth retardation has higher neonatal morbidity and there are some specific guidelines in intrauterine growth retarded infants to control some of their prevalent complications like hypoglycemia. As there are no specific guidelines to control and screen some possible morbidities in babies with more than 2500 gram weight, we decided to determine the association between different ponderal index values and neonatal complications such as hypoglycemia, meconium aspiration syndrome, hyperbilirubinemia, perinatal resuscitation and duration of hospital stay in first born term infants. Three-hundred and sixty-one first born infants were studied during April 2000 to April 2001. Low, appropriate and high ponderal indexes were detected in 20.5%, 51 % and 28.5% of infants respectively. Among these infants, there were 47 intrauterine growth retarded cases. The frequency of hypoglycemia, meconium aspiration syndrome, hyperbilirubinemia and age at hospital discharge with a stay of more than 7 days were higher in the low ponderal index group than the other two groups and the statistical differences were significant (p< 0.05). Comparing neonatal morbidities according to birth weight (more or less than 2500 g), we could not find significant differences except in hypoglycemia (p< 0.05). This study showed that a low ponderal index could be used as a prognostic factor in predicting some morbidity in term neonates. Intrauterine growh retardation Ponderal index Neonatal morbidity. 2003 11 01 197 201 http://mjiri.iums.ac.ir/article-1-681-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 THE EFFICACY OF ORAL RIBAVIRIN IN THE TREATMENT OF 81 PROVED CASES OF CRIMEAN-CONGO HEMORRHAGIC FEVER (CCHF) IN IRAN (1999-2001) M MARDANI mmardani@sbmu.ac.ir M KESHTKAR JAHROMI K HOLAKOI NAINI M ZINALI Crimean-Congo Hemorrhagic Fever is a fatal viral disease that occurs in some parts of Africa, Asia, Eastern Europe and the Middle-East. Primarily it is a zoonosis but can be seen sporadically in humans. Recently outbreaks have been reported from Pakistan, Afghanistan, Saudi Arabia, United Arab Emirates and Iran. In this retrospective study, we evaluated the efficacy of oral Ribavirin in the treatment of CCHF cases, by comparing the outcome in two groups of treated and non-treated confirmed CCHF cases. 81 confirmed CCHF cases (by serology or viral culture) were evaluated for the incidence of outcome (death or recovery ) in the form of an analytic case-control study. 61 out of 69 treated cases and 5 out of 12 non-treated cases survived. Oral Ribavirin with an efficacy of 91 % can be an effective medical therapy for management of Crimean Congo Hemorrhagic Fever. Congo Hemorrhagic Fever Oral Ribavirin Efficacy. 2003 11 01 193 195 http://mjiri.iums.ac.ir/article-1-680-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 A STUDY OF MYCOBACTERIUM TUBERCULOSIS DRUG RESISTANCE IN PULMONARY TUBERCULOSIS SR MOADDAB A RAFI Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the study were to evaluate the frequency of drug-resistance and to survey the nature of drug resistance among patients with pulmonary tuberculosis. Ninety-one M. tuberculosis strains were isolated from sputum samples of patients referred to Cerrhapasa Medical Faculty Hospital, Istanbul, Turkey, during a 9 month period. Drug susceptibility testing was performed to isoniazid (INH), streptomycin (SM), ethambutol (EMB) and rifampin (RMP) on Lowenstein-Jensen medium according to proportion method. Total resistance was identified in 40 of 91 patients (44%). The highest rate of primary resistance was to SM (21.1 %), followed by INH (15.8%), RMP (5.3%) and EMB (2.6%). Secondary resistance was most frequent to INH (33.3%), followed by SM (28.6%), RMP (23.8%) and EMB (14.3%). Multidrug resistance (MDR) was observed in 6 of the 91 cases (6.6%). Due to the high prevalence of drug resistance, particularly in developing countries, further studies should be conducted regularly to monitor resistance in these countries. 2003 11 01 189 192 http://mjiri.iums.ac.ir/article-1-679-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 THE EFFICACY OF HYSTEROSCOPIC ADHESIOLYSIS IN ASHERMAN\'S SYNDROME SAEED ALBORZI MINOO ROBATI MOHAMMAD E. PARSANEJAD To determine the prevalence of Asherman's syndrome in the south of Iran and assess the safety and efficacy of hysteroscopic adhesiolysis in restoration of menstrual function and fertility, a prospective study was done from 1997 to 1999. Among 2300 couples with infertility referring to the infertility clinic of a Shiraz University hospital, 30 patients were proven to have Asherman's syndrome by diagnostic hysterosalpingography (HSG) and then hysteroscopy. T he prevalence of this syndrome was 1.3%. Hysteroscopic adhesiolysis was performed in all 30 patients. Adhesion reformation postoperatively was absent in stage 1 patients, 15% in stage II and 66% in stage III. Normal menstrual flow was restored in all patients (100%), and 19 patients (63.3%) conceived after surgery that resulted in term infants in 15 patients (50%). Hysteroscopic adhesiolysis is. a safe and effective operation for restoring the normal menstrual pattern and fertility, and the severity of the adhesions appear to correlate best with the reproductive outcome. Intrauterine adhesions Hysteroscopic adhesiolysis Infertility. 2003 11 01 185 187 http://mjiri.iums.ac.ir/article-1-678-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 NEUROLOGIC MANIFESTATIONS OF A CUTE GA STROENTERITIS: A REVIEW OF 45 PATIENTS IN THE INTENSIVE CARE SETTING M KADIVAR F TASLIMI Acute gastroenteritis (AGE) is a serious disease and is one of the most important causes of early childhood mortality in developing countries. The neurologic manifestations can be propounded as primary symptoms of AGE. In order to determine the rate, clinical presentations, and outcome of patients with AGE who presented with neurologic manifestations and compare them with patients without neurologic symptoms, we reviewed the records of children 1 month to 14 years of age having AGE along with neurologic presentations, i.e. either convulsion or encephalopathy alone or together who had been admitted to the pediatric intensive care unit (PICU) of the Children's Hospital Medical Center (CHMS) from September 1996 till August 1998. Among all the patients admitted at that time, 7% (75 patients) had AGE, of which 60% (45 patients) had concomitant neurologic symptoms including 4% who had convulsion alone, 20% had encephalopathy alone, and 36% showed both of the symptoms. Of the patients who had AGE with neurologic symptoms, 36% initially presented with neurological manifestations without gastrointestinal symptoms. The duration of admission at PICU and the mortality rate among patients with AGE were significantly more in the patients with neurologic symptoms in comparison to those without neurologic symptoms. According to our findings, neurologic symptoms may be the first manifestation of AGE and are likely to increase the risk of mortality in AGE. Gastroenteritis; acute convulsion encephalopathy. 2003 11 01 179 183 http://mjiri.iums.ac.ir/article-1-677-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 3 EFFECT OF CLINICAL IN FORMATION ON BRAIN CT SCAN IN T ERPRETATION: A BLIN DED DOUBLE CROSSOVER STUDY MOTAHAREH ZHIANPOUR MOHSEN JANGHORBANI janghorbani@yahoo.com Errors and variations in interpretation can happen in clinical imaging. Few studies have examined the biased effect of clinical information on reporting of brain CT scans. In a blinded double crossover design, we studied whether three radiologists were biased by clinical information when making CT scan diagnosis of the brain. Three consultant radiologists in three rounds with at least a one-month interval assessed 100 consecutive cases of brain CT scan. In the first round, clinical information was not available and 100 films without clinical information were given to radiologists. In the second round, the same 100 films were given and true clinical information was available. In the third round, the same 100 films were given and false clinical information was allocated. In 180 cases (60%) the evaluation resulted in the same diagnosis on all three occasions (95% confidence interval (CI): 54.5,65.5), whereas 120 (400/0 95% CI: 34.5,45.5) sets were evaluated differently. 48 cases (16% 95% CI: 11.9, 20.1) had discordant evaluation with true and 33 (11 % 950/0 CI: 7.5,14.5) with false clinical information. Discordance without and with true and false clinical information was 39 (13% 95% CI: 9.2, 16.8). Correct clinical information improves the brain CT report, while the report became less accurate after false clinical information was allocated. These results indicate that radiologists are biased by clinical information when reporting brain CT scans. Clinical information radiology CT scan bias Iran. 2003 11 01 173 177 http://mjiri.iums.ac.ir/article-1-676-en.pdf