2024-03-29T02:19:18+04:30
http://mjiri.iums.ac.ir/browse.php?mag_id=40&slc_lang=en&sid=1
40-728
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
OCULAR DIROFILARIASIS IN IRAN: A CASE REPORT
S
ROUHANI
Srouhani11@yahoo.com
A
ATHARI
Dirofilariasis is caused by a Filariid parasite of the genus Dirofilaria. This
zoonotic infection is spread by mosquito vector from animal to human. Ocular
Dirofilariasis involving the eye and adnexa is rare. A nodule in the right eye had
developed in a 20-year-old soldier from Mazandaran province, north of Iran. The
mass was removed surgically and measured 5x5 mm. The specimen was identified
on the basis of microscopic section by the presence of longitudinal cuticular
ridges, the thick muscle cell layer and the presence of 2 nuclei in the lateral cord.
The worm was identified as a Dirofilaria, (presumptively D. conjunctivae). This
report is one of the first reports of ocular Dirofilariasis from Iran.
Dirofilariasis
Dirofilaria repens
ocular
human
2003
5
01
85
86
http://mjiri.iums.ac.ir/article-1-728-en.pdf
40-727
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
PONCET\'S DISEASE: A REPORT OF FOUR CASES AND REVIEW OF THE LITERATURE
B
HEIDARI
beheidai@yahoo.com
K
BUANI
Four cases of polyarthritis concomitant with active tuberculosis is reported.
In three patients pulmonary tuberculosis was confirmed by identification of Mycobacterium
tuberculosis in the sputum and bronchoalveolar lavage specimens,
and in another one tuberculous lymphadenitis was confirmed by excisional biopsy.
In all patients arthritis resolved by tuberculosis treatment and did not recur
during a follow up period of 18 months to 12 years.
The findings of the presented cases are compatible with Poncet's disease
(tuberculous reactive arthritis).
Reactive arthritis
Tuberculosis
Poncet\'s disaese.
2003
5
01
81
83
http://mjiri.iums.ac.ir/article-1-727-en.pdf
40-726
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
COMPARISON OF VAL IDITY OF MICROLYMPHOCYTOTOXICITY AND FLOWCYTOMETRY METHODS WITH PCR FOR HL A-B27 ANTIGEN TYPING
MH
NICKNAM
nicknam_m@yahoo.com
AR
JAMSHIDI
M
GANJALIKHANI HAKEMI
F
KHOSRAVI
A
AMIRKHANI
M
NAROUINEJAD
B
NIKBIN
The Human Major Histocompatibility Complex (MHC) plays a crucial role
in transplantation, transfusion, paternity test and assessment of susceptibility to
some diseases associated with HLA-B27. Three of the most fashionable methods
for determination of HLA antigens in clinical and research laboratories are
microlymphocytotoxicity (MLCT), flowcytometry and polymerase chain reaction
(PCR).
The purpose of this study was to compare the sensitivity, specificity, and
positive and negative predictive values of MLCT and flowcytometry methods
with PCR as a gold standard method in determination of HLA-B27 antigen.
In the present study, all three above-mentioned techniques have been used
for 36 patients suffering from ankylosing spondylitis and 31 healthy volunteers.
Specific antisera and monoclonal antibodies against HLA-B27, and allele specific
PCR have been used in MLCT, flowcytometry and PCR methods respectively.
The results show that sensitivity, specificity, positive and negative predictive
values of MLCT method as compared with PCR technique were 83.3%, 100%,
100% and 88.1 % respectively. Moreover, sensitivity, specificity, positive and negative
predictive values of flowcytometry compared to the PCR technique were
100%, 94.6%, 93.8% and 100% respectively.
Based on the results, the flowcytometry method in determination of HLAB27
is more valid than MLCT in this regard, particularly in research programs.
The similarity between the results of our study and those studies done in Europe
suggests the probability of resemblance between HLA-B27 subtypes in Europe
and in Iran.
Ankylosing spondylitis
Flowcytometry
HLA-B27
Microlymphocytotoxicity
PCR
2003
5
01
75
79
http://mjiri.iums.ac.ir/article-1-726-en.pdf
40-724
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS
A
A. SAMADI
asamadi@kcom.edu
S
ALVANI
M
GHAZI-KHONSARI
Human serum paraoxonase (PON) associated with high density lipoprotein
(HDL) , has been postulated to have a role in protecting low-density lipoprotein
(LDL) against oxidative damage, which has led to the proposal that PON is an
anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at
the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and
AB. We examined the activity of arylesterase and paraoxonase among healthy
individuals and in patients with hypercholesterolemia. Equal activity distribution
was observed among males and females for both enzymes. Arylesterase activity
displayed a normal distribution in the population under study. However,
paraoxonase activity demonstrated a three modal activity. Population distribution
of A, B and AB polymorphism were 46, 10 and 44 percent respectively. A significant
direct correlation between paraoxonase activity and triglyceride levels was
observed (p<O.05) whereas arylesterase activity was similar among hyperlipidemic
and control groups. The lack of a significant relationship between lipids and lipoproteins
and PON phenotypes, suggests that PON phenotypes do not influence
the lipid profile.
Paraoxonase
Arylesterase
Lipids
Lipoproteins
Arteriosclerosis
Polymorphism.
2003
5
01
67
73
http://mjiri.iums.ac.ir/article-1-724-en.pdf
40-725
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
ANTISENSE RNA TO THE TYPE I INSULIN-LIKE GROWTH FACTOR RECEPTOR REVERSED THE TRANSFORMED PHENOTYPE OF PC-3 HUMAN PROSTATE CANCER CELL LINE IN VITRO
R
JALAL
A
DIZAGI
K
NAYERNIA
B
GOLIAEI
goliaei@ibb.ut.ac.ir
The insulin-like growth factor I receptor (IGF-IR) plays an essential role in
the establishment and maintenance of transformed phenotype. Interference with
the IGF-IR pathway by antisense causes reversal of the transformed phenotype in
many rodent and human tumor cell lines. We stably transfected the PC-3 human
prostate cancer cell line with an IGF-IR antisense RNA expression plasmid. The
number of IGF-I receptors on the antisense-transfected PC-3 cells was reduced by
40.2% relative to the control-transfected cells. The transfected cells maintained
their high expression of IGF-IR antisense RNA for up to one year in selective
medium . The reduction in the expression of IGF-IR had no effect on the cell
growth in monolayer. The clonogenicity of antisense-transfected cells was 24.7%
of the clonogenicity of control-transfected cells in soft agar. There was a good
correlation between IGF-IR level and inhibition of transformation in soft agar.
These results indicate that reduction of IGF-IR by antisense RNA can reverse the
transformed phenotype of human prostate cancer cells.
Type I insulin-like growth factor receptor; Antisense; Transfonnation; prostate cancer; PC- 3.
2003
5
01
59
66
http://mjiri.iums.ac.ir/article-1-725-en.pdf
40-723
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
DEV ELOPMENT, VALIDATION AND RELIABILITY OF CHILD ABUSE SELF REPORT SCALE (CASRS) IN IRANIAN STUDENTS
P
MOHAMMADKHANI
MR
MOHAMMADI
MA
NAZARI
M
SALAVATI
OM
RAZZAGHI
Diagnosing and assessing child abuse is a critical and difficult process in
clinical psychology, because this phenomenon has several negative behavioral
and psychological consequences on victims. The aim of this research is to create
a scale for assessing child abuse and neglect. Through a multiclustral sampling,
3042 secondary school students (boys and girls) were selected to fill (1) a list of
54 items (Child Abuse and Self Report Scale, CASRS) which assess four categories
of child abuse and neglect, after approving through content validity and (2)
Trauma Symptom Checklist for Children (TSCC-A) in order to assign construct
validity and comorbid psychopathology. Then, we did a clinical interview with a
sample group who were diagnosed as abused children according to CASRS and
TSCC-A. In addition, these scales were completed by a group of abused children
as criterion group, for assigning criterion validity. In order to assign the reliability
of CASRS and TSCC-A, after 3 weeks test-retest was done. Through a factor
analysis , the best items were assigned. The results showed that CASRS and TSCCA
have excellent reliability and validity. Also, its stability was at an appropriate
level. In addition, factor analysis showed that 38 items were the best questions for
assessing child abuse. We believe that CASRS is an instrument which measures
child abuse during the current life. It is brief (6 to 8 minutes for the core scales)
and practical for epidemiological researches on child abuse, maltreatment and
clinical screening. Methodological issues inherent in child self-report measures
of abuse are discussed.
Child abuse
scale
reliability
validity
self report
Child Abuse and Self Report Scale (CASRS)
2003
5
01
51
58
http://mjiri.iums.ac.ir/article-1-723-en.pdf
40-722
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
FREQUENCY OF HYPOCALCEMIA IN LOW BIRTH WEIGHT INFANTS AT HOSPITALS IN KASHAN IN 1997
A
A. HONARPISHEH
Considering the fact that early hypocalcemia is the most common type of
neonatal hypocalcemia which manifests during the first few days of Iife (72 hours)
and that hypocalcemia in low birth weight neonates is very common, this descriptive
study on hypocalcemia was conducted to determine the frequency of hypocalcemia
in low birth weight neonates in the city of Kashan in the first 9 months of
the year 1997. A total of 250 infants weighing less than 2.5 kg were included in
this study. Variables such as gestational age, APGAR score, birth weight, preeclampsia
of mother and age of pregnancy were recorded. All of the newborns
were checked and laboratory tests for serum calcium level were performed on
them. Any full-term infant with a serum calcium level less than 8 mg/dL or preterm
infants with serum calcium levels less than 7 mg/dL were identified as hypocalcemic
infants. The results of the study showed that 22.4% of the infants
were hypocalcemic, most of these being neonates below ls00g weight. The frequency
of hypocalcemia in infants whose mothers were afflicted by pre-eclampsia
was 30.8%. The frequency of hypocalcemia in infants with low APGAR score
was 28.8% and for those neonates with a normal APGAR score, 21.2% (p
value<O.O 1). The frequency rate of hypocalcemia in full-term and pre-term infants
was 29.7 and 20.2% respectively (p-value<O.Os).
Considering the high prevalence of hypocalcemia in low birth weight infants,
it is recommended that all infants weighing less than 2.5 kg with or without
clinical signs undergo screening tests and their level of calcium measured so that
prompt treatment can be provided to prevent the serious consequences of this disorder.
Hypocalcemia
low birth weight infant.
2003
5
01
47
50
http://mjiri.iums.ac.ir/article-1-722-en.pdf
40-721
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
THERAPEUTIC EFFECTS OF LASER PHOTOCOAGULATION AND VITRECTOMY IN EALES\'DISEASE
MH
DEHGHAN
labbafi@hotmail.com
H
AHMADIEH
M
SOHEILIAN
M
AZARMINA
A
MASHAYEKHI
J
NAGHIBOZAKERIN
Eales' disease is an idiopathic obliterative retinal vasculopathy that is treated
with laser photocoagulation, and/or vitrectomy. In order to determine visual outcomes
and regression of retinal neovascularization following scattered peripheral
retinal photocoagulation, and/or vitrectomy in cases with Eales' disease, we did a
retrospective study of the records of these patients treated in Labbafinejad Medical
Center from 1988 to 1998.
We studied the existing data of 67 eyes of 54 patients with complicated Eales'
disease who had undergone laser photocoagulation and/or vitrectomy based on
their clinical presentations.
Our main outcome measure was the visual acuity changes of the eyes following
treatment.
In 43 eyes, scattered peripheral retinal photocoagulation alone led to complete
regression of neovascularization and a VA of 20/30 was obtained in 60.4%.
Vitrectomy was finally required in 24 eyes and of these, 37.5% gained a VA of 20/
30.
Although scattered peripheral retinal photocoagulation should be the first
line of treatment in Eales' disease, it may not always produce regression of retinal
neovascularization. In such cases vitrectomy may further enhance therapeutic
success.
Eales\'
Photocoagulation
Vitrectomy.
2003
5
01
41
45
http://mjiri.iums.ac.ir/article-1-721-en.pdf
40-720
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
STUDY OF FATIGUE IN WORKING PREGNANT WOMEN
M
POURJAVAD
mpourjavad@yahoo.com.
A
MANSOORI
The purpose of the study is to show in which trimester of pregnancy is fatigue
more common among working women, and whether or not there is any
relationship between fatigue rate and educational level, income, etc.
This is a longitudinal study. From the total number of patients who came to
Zeinab University Hospital, 100 completed a demographics 50 item questionnaire
and the numerical rating scale fatigue (NRS-F) was obtained. I Of those,
only 35 patients were in their first trimester of pregnancy and qualified for the
study and filled the questionnaire again at 2nd and 3rd trimesters.
The fatigue rate was higher in the first than the two other trimesters of pregnancy
(f=126.78, p<0.001). In unwanted pregnancies with no moral support b y
the husband or other family members, the fatigue rate was not significant. There
is a relationship between fatigue rate and the education level of these women
(f=8.569, p=0.001) and income (f=10.72, p<0.001). When medical instructions
had to be given to a patient to do less work or rest at home, the fatigue rate was
significantly higher than those who did not (f=17.34, p<0.001).
In conclusion, it appears that health personel working with childbearing populations
should counsel women about significant 1st trimester fatigue so they can
prepare their work and home environments in an attempt to achieve adequate
rest.
Fatigue
Work
Pregnancy
Childbearing.
2003
5
01
35
39
http://mjiri.iums.ac.ir/article-1-720-en.pdf
40-719
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
A STUDY COMPARING CEREBROSPINAL FLUID LACTATE LEVELS IN CHILDHOOD CULTURE POSITIVE AND CULTURE NEGATIVE MENINGITIS
M
KEYHANI
Despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial
meningitis, solid data-necessary for early determination of bacterial meningitis
(BM) before organism growth in the culture medium-are missing. Therefore
cerebrospinal fluid (CSF) lactate levels were evaluated as a possible means
of differentiating the two clinical entities. This was a retrospective study. Patients
were studied in one year. They were divided into three groups: Group one included
10 patients with culture positive meningitis Group two included 10 patients
with culture negative meningitis compatible with a viral etiology Group
three consisted of 10 febrile children without any biochemical or cytological CSF
abnormality as the normal controls.
CSF lactate level determinations were made enzymatically with Boehringer
Mannheim reagents in addition to the formal biochemical and cytological investigations,
consisting of cell counts and differential plus glucose and protein levels
and CSF/blood glucose ratio in all three groups. Group one had a mean CSF
lactate level of 12.90 (±3.08) mmol/L, while in groups 2 and 3 the level was 1.89
(± 0.52) mmoL/l and 1.63 (±0.31) mmol/L respectively. Lactate levels were significantly
higher in patients from group one with respect to the control group (p=
0.001) whereas there were no significant differences between group 2 and the
control group. Regarding temporal profile of CSF markers and considering the
rapid rise in CSF lactate levels in bacterial meningitis, its measurement seems
appealing to confirm a bacterial etiology instead of awaiting the results of CSF
culture.
CSF
Lactate
Bacterial Meningitis
Non-bacterial Meningitis.
2003
5
01
29
34
http://mjiri.iums.ac.ir/article-1-719-en.pdf
40-718
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
SUCCESSFUL PREGNANCY OUTCOME WITH lUI IN PATIENTS WITH UNEXPLAINED RECURRENT MISCARRIAGE, WHOSE MALE PARTNERS HAVE LOW SCORE HYPO-OSMOTIC SWELLING TEST
J
ZOLGHADRI
jzoighad@yahoo.com
A
GHADERI
S
ALBORZI
ME
PARSANEZHAD
In order to determine outcome of pregnancy with lUI in patients with unexplained
recurrent miscarriage whose husbands have low hypo-osmotic swelling
test scores, a prospective clinical intervention was performed at a university referral
clinic of recurrent abortion.
Out of 56 patients whose husbands had abnormal hypo-osmotic swelling
tests, 43 patients underwent lUI, from which only 14 patients became pregnant
(treatment group) and 13 patients became spontaneously pregnant without lUI as
control group.
Our main outcome measure was successful pregnancy (continuation of pregnancy
after 20 weeks).
Among the 14 patients who became pregnant, 3 patients aborted below 20
weeks (21.4%), and 11 patients continued pregnancy after 20 weeks of gestation
(78.6%). In the control group among the 13 patients with spontaneous pregnancy,
8 patients aborted below 20 weeks (61.5%) and 5 patients continued pregnancy
over 20 weeks (36.4%), success rate ratio was 2.04% and the difference was statistically
significant (d= 4.49, p<0.05).
Treating the unexplained recurrent aborter whose male partner has a low
hypo-osmotic swelling test score with lUI could be effective. This is the first
study to present an ideal way for selection of recurrent aborters who benefit from
lUI. The probable mechanism for this effect may be selection of the best quality
sperms which will be discussed in detail.
Recurrent miscarriage
Hypo-osmotic swelling test
lUI.
2003
5
01
25
27
http://mjiri.iums.ac.ir/article-1-718-en.pdf
40-717
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
ASSESSMENT OF THE RELATION BETWEEN AGE AT MENARCHE, ANTHROP OMETRIC PARAMETERS AND INTELLIGENCE QUOTIENT IN MASHHAD, IRAN
Z
YUSOFI
N
RAJAIE
The present study was initiated to derive an indirect method for estimating
body fat mass (BFM) and to evaluate the correlation between indirect anthropometric
techniques for this estimation and to examine the relation of these parameters
and of IQ to age of menarche.
A total of 578 adolescent girls of ten junior high schools in five educational
districts of Mashhad, participated in a cross sectional study during autumn 2000.
The data were gathered through questionnaires, interview, measurement of anthropometric
parameters including: weight, height, BMI (Body Mass Index), TSF
(Triceps Skin Fold) thickness, SSSF (Sub-Scapular Skin Fold) thickness, MUAC
(Middle Upper Arm Circumference), and measurement of IQ by Raven test.
We demonstrated that anthropometric parameters for estimating BFM correlated
well with each other. Age at menarche did not correlate with BFM measured
by anthropometric parameters when studied at the onset of menarche, but it did
well correlate negatively with these indices if studied any time postmenarche,
regardless of the interval between the onset of menarche and the present age
(p<0.001).
IQ correlated negatively to the age at menarche (p< 0.001). These findings
implicate that BFM does not trigger puberty onset in healthy girls, but it does
accumulate with a faster rate in the postmenarcheal period so that girls who have
an earlier menarche have a higher weight and BMI and greater skinfold thickness
than those who enter the menarcheal stage at a later time, and that mental development
and physical growth are parallel processes, so that a slower mental development
would be expected when physical growth is delayed.
Menarche
BM!
MUAC
TSF
SSSF
IQ
Age at Menarche.
2003
5
01
19
24
http://mjiri.iums.ac.ir/article-1-717-en.pdf
40-714
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
LAMOTRIGINE AS ADD-ON THERAPY IN CHILDREN WITH DRUG-RESISTANT EPILEPSY (IRANIAN EXPERIENCE)
M
BARZEGAR
SH
TONEKABONI
M
GHOFRANI
Lamotrigine (LTG), a newly developed antiepileptic drug (AED), is efficacious
in treating refractory epilepsy. This study was designed to evaluate the efficacy
and safety of LTG as add-on therapy in 40 children with refractory epilepsy.
The trial was an open-labeled prospective study in children with drug-resistant
epilepsy aged
Lamotrigine
refractory epilepsy
add-on therapy.
2003
5
01
15
18
http://mjiri.iums.ac.ir/article-1-714-en.pdf
40-713
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
LYMPH NODE REVEALING SOLUTION: A NEW USEFUL METHOD FOR ISOLATION OF MINUTE AXILLARY LYMPH NODES IN BREAST CANCER
B
GERAMIZADEH
A
RAZAVI
Breast cancer is one of the most common malignancies in the world. The
most important prognostic factor in this cancer is the stage of the tumor. Detection
of lymph nodes with or without malignancy is essential for determining the
stage of the tumor and setting a therapeutic plan.
There are different methods for isolating lymph nodes in surgical specimens
of breast cancer in the pathology department.
The most popular method is routine palpation, but isolation of very small
lymph nodes is difficult and time consuming and some may be missed. The main
goal of this paper is to describe a new, precise and easy technique for finding
nodes in breast cancer specimens.
In this study 50 cases of breast cancer were randomly selected. In these cases
axillary fat was examined for lymph nodes by traditional method, and then the
entire axillary fat was immersed overnight in a lymph node revealing solution
(LNRS) composed of various traditional fixatives and fat solvent. After overnight
fixation the lymph nodes stood out as white chalky nodules on the background
of yellow fat. They were then excised, processed and stained by routine
H;E method.
The total number of lymph nodes found by traditional method in these 50
cases was 660. After application of LNRS, 178 additional lymph nodes measuring
from 0.5 to 9 mm were found. The LNRS increased the mean number of
nodes per case from 13.20+/-6.61 found by traditional method to 16.67+/-7.64
nodes per case (p value<O.01).
The size of lymph nodes identified by LNRS was significantly smaller than
those found by traditional method (p value<O.OI).
In 8 cases, tumor stage was increased by application of LNRS in addition to
routine palpation.
As a whole LNRS is a useful, rapid and good fixative. It significantly enhances
the yield of lymph nodes in the axillary fat of breast cancer specimens.
2003
5
01
11
14
http://mjiri.iums.ac.ir/article-1-713-en.pdf
40-711
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
A CROSS-SECTIONAL CONTROLLED STUDY OF GONADAL FUNCTION AND PUBERTAL DEVELOPMENT IN THALASSEMIA MAJOR
AA
VAHIDI
MH
TORABINEJAD
A
AHMADI
Z
FARAHMANDINIA
G
KIANI MOGHADDAM
ghasemkiani@yahoo.com
B
MEGHDADI
Early and regular blood transfusion therapy in patients with homozygous
beta-thalassemia decreases the complications of severe anemia and prolongs survival.
In the long term, however, the beneficial effects of transfusions are limited
by the organ damage resulting from iron overload. Endocrine complications in
patients with thalassemia major in developing countries may be frequent due t o
suboptimal iron chelation.
T he goal of this study was to investigate the gonadal function and secondary
sex characteristics in thalassemic patients. We studied 71 randomly selected adolescent
thalassemic patients and 30 age- and sex-matched controls. Sexual maturity
rating (SMR), height and weight, and gonadotropin, sex steroid, and ferritin
levels were evaluated.
Cases had significantly lower mean height and weight. Also, serum levels of
gonadotropins and sex hormones were significantly lower in cases with thalassemia
than in controls. Gonadotropin and sex steroid levels were lower in cases
with thalassemia who had not used deferoxarnine regularly compared to those
with a regular chelation therapy regimen. All of the control subjects had sexual
maturity ratings of II or above, while 36.6% of thalassemic cases were in Tanner
stage I. About 53.3% of controls had surpassed all levels of sexual maturity, while
only 2.8% of cases were in the stage SMR V. Distribution of SMR ratings was
significantly different in cases and controls.
These findings clearly show that a high percentage of thalassemic patients in
this part of the country suffer from various endocrine abnormalities, especially
impairment in height growth and sexual maturity. It is wise to consider more
sophisticated treatment modalities in these patients, including the administration
of sex hormones for the compensation of hormonal abnormalities resulting from
hemosiderosis.
β-thalassemia major
endocrine function
puberty
2003
5
01
5
10
http://mjiri.iums.ac.ir/article-1-711-en.pdf
40-710
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2003
17
1
LIVING-RELATED LIVER TRANSPLANTATION IN CHILDREN: THE SHIRAZ EXPERIENCE
SA
MALEK-HOSSEINI
M
LAHSAIE
H
SALAHI
A
BAHADOR
M
HAGHIGHAT
MJ
KAVIANI
MB
KHOSRAVI
M
BORZOIE
M
ARASTEH
MH
BAGHERI
M
FATTAHI
HR
DAVARI
S
NIK-EGHBAL
A
KARBASSI
The liver transplantation program was established at Shiraz Nemazee Hospital
in 1993. Shortage of cadaver organ supply due to various social and legal
issues urged us to develop a living-related liver transplantation (LRLT) program.
So far 7 (6 males, 1 female) living-related liver transplantations have been performed
at this center. The mean age of patients was 8.21 years (+/- 4.16), with a
range of 4.5 to 14 years. Live donors (3 mothers, 2 fathers, and 1 brother) with a
mean age of 30.83 years (+/- 4.11) underwent procurement of the left lateral segment
without mortality or any serious morbidity. The native liver disease was
idiopathic cirrhosis (1 case), biliary atresia (3 cases), Budd-Chiari syndrome (1
case), neonatal cirrhosis (l case), and cryptogenic cirrhosis (l case). Allografts
were implanted using piggy-back surgical technique. Baseline immunosuppression
consisted of a triple drug regimen including cyclosporine, mycophenolate
mofetil and steroids. Acute graft rejection was treated with intra-venous bolus of
methyl-prednisolone. Early death occurred in 2 patients due to vascular thrombosis.
Biliary complication was observed in 1 patient. Five patients are alive with a
normal functioning liver. In conclusion, LRLT program is promising in Iran. It
can help to overcome the shortage of organs and minimize the mortality of patients
in the waiting list.
Liver transplantation
Living-related
Children
2003
5
01
1
3
http://mjiri.iums.ac.ir/article-1-710-en.pdf