2024-03-29T02:19:18+04:30 http://mjiri.iums.ac.ir/browse.php?mag_id=40&slc_lang=en&sid=1
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 OCULAR DIROFILARIASIS IN IRAN: A CASE REPORT S ROUHANI Srouhani11@yahoo.com A ATHARI Dirofilariasis is caused by a Filariid parasite of the genus Dirofilaria. This zoonotic infection is spread by mosquito vector from animal to human. Ocular Dirofilariasis involving the eye and adnexa is rare. A nodule in the right eye had developed in a 20-year-old soldier from Mazandaran province, north of Iran. The mass was removed surgically and measured 5x5 mm. The specimen was identified on the basis of microscopic section by the presence of longitudinal cuticular ridges, the thick muscle cell layer and the presence of 2 nuclei in the lateral cord. The worm was identified as a Dirofilaria, (presumptively D. conjunctivae). This report is one of the first reports of ocular Dirofilariasis from Iran. Dirofilariasis Dirofilaria repens ocular human 2003 5 01 85 86 http://mjiri.iums.ac.ir/article-1-728-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 PONCET\'S DISEASE: A REPORT OF FOUR CASES AND REVIEW OF THE LITERATURE B HEIDARI beheidai@yahoo.com K BUANI Four cases of polyarthritis concomitant with active tuberculosis is reported. In three patients pulmonary tuberculosis was confirmed by identification of Mycobacterium tuberculosis in the sputum and bronchoalveolar lavage specimens, and in another one tuberculous lymphadenitis was confirmed by excisional biopsy. In all patients arthritis resolved by tuberculosis treatment and did not recur during a follow up period of 18 months to 12 years. The findings of the presented cases are compatible with Poncet's disease (tuberculous reactive arthritis). Reactive arthritis Tuberculosis Poncet\'s disaese. 2003 5 01 81 83 http://mjiri.iums.ac.ir/article-1-727-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 COMPARISON OF VAL IDITY OF MICROLYMPHOCYTOTOXICITY AND FLOWCYTOMETRY METHODS WITH PCR FOR HL A-B27 ANTIGEN TYPING MH NICKNAM nicknam_m@yahoo.com AR JAMSHIDI M GANJALIKHANI HAKEMI F KHOSRAVI A AMIRKHANI M NAROUINEJAD B NIKBIN The Human Major Histocompatibility Complex (MHC) plays a crucial role in transplantation, transfusion, paternity test and assessment of susceptibility to some diseases associated with HLA-B27. Three of the most fashionable methods for determination of HLA antigens in clinical and research laboratories are microlymphocytotoxicity (MLCT), flowcytometry and polymerase chain reaction (PCR). The purpose of this study was to compare the sensitivity, specificity, and positive and negative predictive values of MLCT and flowcytometry methods with PCR as a gold standard method in determination of HLA-B27 antigen. In the present study, all three above-mentioned techniques have been used for 36 patients suffering from ankylosing spondylitis and 31 healthy volunteers. Specific antisera and monoclonal antibodies against HLA-B27, and allele specific PCR have been used in MLCT, flowcytometry and PCR methods respectively. The results show that sensitivity, specificity, positive and negative predictive values of MLCT method as compared with PCR technique were 83.3%, 100%, 100% and 88.1 % respectively. Moreover, sensitivity, specificity, positive and negative predictive values of flowcytometry compared to the PCR technique were 100%, 94.6%, 93.8% and 100% respectively. Based on the results, the flowcytometry method in determination of HLAB27 is more valid than MLCT in this regard, particularly in research programs. The similarity between the results of our study and those studies done in Europe suggests the probability of resemblance between HLA-B27 subtypes in Europe and in Iran. Ankylosing spondylitis Flowcytometry HLA-B27 Microlymphocytotoxicity PCR 2003 5 01 75 79 http://mjiri.iums.ac.ir/article-1-726-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 PARAOXONASE AND ARYLESTERASE ACTIVITY AMONG HYPERCHOLESTEROLEMIC PATIENTS A A. SAMADI asamadi@kcom.edu S ALVANI M GHAZI-KHONSARI Human serum paraoxonase (PON) associated with high density lipoprotein (HDL) , has been postulated to have a role in protecting low-density lipoprotein (LDL) against oxidative damage, which has led to the proposal that PON is an anti-atherogenic and anti-inflammatory enzyme. It has genetic polymorphism at the 191 (R ->Q) and two alloenzymes A and B and three phenotypes A, B, and AB. We examined the activity of arylesterase and paraoxonase among healthy individuals and in patients with hypercholesterolemia. Equal activity distribution was observed among males and females for both enzymes. Arylesterase activity displayed a normal distribution in the population under study. However, paraoxonase activity demonstrated a three modal activity. Population distribution of A, B and AB polymorphism were 46, 10 and 44 percent respectively. A significant direct correlation between paraoxonase activity and triglyceride levels was observed (p<O.05) whereas arylesterase activity was similar among hyperlipidemic and control groups. The lack of a significant relationship between lipids and lipoproteins and PON phenotypes, suggests that PON phenotypes do not influence the lipid profile. Paraoxonase Arylesterase Lipids Lipoproteins Arteriosclerosis Polymorphism. 2003 5 01 67 73 http://mjiri.iums.ac.ir/article-1-724-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 ANTISENSE RNA TO THE TYPE I INSULIN-LIKE GROWTH FACTOR RECEPTOR REVERSED THE TRANSFORMED PHENOTYPE OF PC-3 HUMAN PROSTATE CANCER CELL LINE IN VITRO R JALAL A DIZAGI K NAYERNIA B GOLIAEI goliaei@ibb.ut.ac.ir The insulin-like growth factor I receptor (IGF-IR) plays an essential role in the establishment and maintenance of transformed phenotype. Interference with the IGF-IR pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. We stably transfected the PC-3 human prostate cancer cell line with an IGF-IR antisense RNA expression plasmid. The number of IGF-I receptors on the antisense-transfected PC-3 cells was reduced by 40.2% relative to the control-transfected cells. The transfected cells maintained their high expression of IGF-IR antisense RNA for up to one year in selective medium . The reduction in the expression of IGF-IR had no effect on the cell growth in monolayer. The clonogenicity of antisense-transfected cells was 24.7% of the clonogenicity of control-transfected cells in soft agar. There was a good correlation between IGF-IR level and inhibition of transformation in soft agar. These results indicate that reduction of IGF-IR by antisense RNA can reverse the transformed phenotype of human prostate cancer cells. Type I insulin-like growth factor receptor; Antisense; Transfonnation; prostate cancer; PC- 3. 2003 5 01 59 66 http://mjiri.iums.ac.ir/article-1-725-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 DEV ELOPMENT, VALIDATION AND RELIABILITY OF CHILD ABUSE SELF REPORT SCALE (CASRS) IN IRANIAN STUDENTS P MOHAMMADKHANI MR MOHAMMADI MA NAZARI M SALAVATI OM RAZZAGHI Diagnosing and assessing child abuse is a critical and difficult process in clinical psychology, because this phenomenon has several negative behavioral and psychological consequences on victims. The aim of this research is to create a scale for assessing child abuse and neglect. Through a multiclustral sampling, 3042 secondary school students (boys and girls) were selected to fill (1) a list of 54 items (Child Abuse and Self Report Scale, CASRS) which assess four categories of child abuse and neglect, after approving through content validity and (2) Trauma Symptom Checklist for Children (TSCC-A) in order to assign construct validity and comorbid psychopathology. Then, we did a clinical interview with a sample group who were diagnosed as abused children according to CASRS and TSCC-A. In addition, these scales were completed by a group of abused children as criterion group, for assigning criterion validity. In order to assign the reliability of CASRS and TSCC-A, after 3 weeks test-retest was done. Through a factor analysis , the best items were assigned. The results showed that CASRS and TSCCA have excellent reliability and validity. Also, its stability was at an appropriate level. In addition, factor analysis showed that 38 items were the best questions for assessing child abuse. We believe that CASRS is an instrument which measures child abuse during the current life. It is brief (6 to 8 minutes for the core scales) and practical for epidemiological researches on child abuse, maltreatment and clinical screening. Methodological issues inherent in child self-report measures of abuse are discussed. Child abuse scale reliability validity self report Child Abuse and Self Report Scale (CASRS) 2003 5 01 51 58 http://mjiri.iums.ac.ir/article-1-723-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 FREQUENCY OF HYPOCALCEMIA IN LOW BIRTH WEIGHT INFANTS AT HOSPITALS IN KASHAN IN 1997 A A. HONARPISHEH Considering the fact that early hypocalcemia is the most common type of neonatal hypocalcemia which manifests during the first few days of Iife (72 hours) and that hypocalcemia in low birth weight neonates is very common, this descriptive study on hypocalcemia was conducted to determine the frequency of hypocalcemia in low birth weight neonates in the city of Kashan in the first 9 months of the year 1997. A total of 250 infants weighing less than 2.5 kg were included in this study. Variables such as gestational age, APGAR score, birth weight, preeclampsia of mother and age of pregnancy were recorded. All of the newborns were checked and laboratory tests for serum calcium level were performed on them. Any full-term infant with a serum calcium level less than 8 mg/dL or preterm infants with serum calcium levels less than 7 mg/dL were identified as hypocalcemic infants. The results of the study showed that 22.4% of the infants were hypocalcemic, most of these being neonates below ls00g weight. The frequency of hypocalcemia in infants whose mothers were afflicted by pre-eclampsia was 30.8%. The frequency of hypocalcemia in infants with low APGAR score was 28.8% and for those neonates with a normal APGAR score, 21.2% (p value<O.O 1). The frequency rate of hypocalcemia in full-term and pre-term infants was 29.7 and 20.2% respectively (p-value<O.Os). Considering the high prevalence of hypocalcemia in low birth weight infants, it is recommended that all infants weighing less than 2.5 kg with or without clinical signs undergo screening tests and their level of calcium measured so that prompt treatment can be provided to prevent the serious consequences of this disorder. Hypocalcemia low birth weight infant. 2003 5 01 47 50 http://mjiri.iums.ac.ir/article-1-722-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 THERAPEUTIC EFFECTS OF LASER PHOTOCOAGULATION AND VITRECTOMY IN EALES\'DISEASE MH DEHGHAN labbafi@hotmail.com H AHMADIEH M SOHEILIAN M AZARMINA A MASHAYEKHI J NAGHIBOZAKERIN Eales' disease is an idiopathic obliterative retinal vasculopathy that is treated with laser photocoagulation, and/or vitrectomy. In order to determine visual outcomes and regression of retinal neovascularization following scattered peripheral retinal photocoagulation, and/or vitrectomy in cases with Eales' disease, we did a retrospective study of the records of these patients treated in Labbafinejad Medical Center from 1988 to 1998. We studied the existing data of 67 eyes of 54 patients with complicated Eales' disease who had undergone laser photocoagulation and/or vitrectomy based on their clinical presentations. Our main outcome measure was the visual acuity changes of the eyes following treatment. In 43 eyes, scattered peripheral retinal photocoagulation alone led to complete regression of neovascularization and a VA of 20/30 was obtained in 60.4%. Vitrectomy was finally required in 24 eyes and of these, 37.5% gained a VA of 20/ 30. Although scattered peripheral retinal photocoagulation should be the first line of treatment in Eales' disease, it may not always produce regression of retinal neovascularization. In such cases vitrectomy may further enhance therapeutic success. Eales\' Photocoagulation Vitrectomy. 2003 5 01 41 45 http://mjiri.iums.ac.ir/article-1-721-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 STUDY OF FATIGUE IN WORKING PREGNANT WOMEN M POURJAVAD mpourjavad@yahoo.com. A MANSOORI The purpose of the study is to show in which trimester of pregnancy is fatigue more common among working women, and whether or not there is any relationship between fatigue rate and educational level, income, etc. This is a longitudinal study. From the total number of patients who came to Zeinab University Hospital, 100 completed a demographics 50 item questionnaire and the numerical rating scale fatigue (NRS-F) was obtained. I Of those, only 35 patients were in their first trimester of pregnancy and qualified for the study and filled the questionnaire again at 2nd and 3rd trimesters. The fatigue rate was higher in the first than the two other trimesters of pregnancy (f=126.78, p<0.001). In unwanted pregnancies with no moral support b y the husband or other family members, the fatigue rate was not significant. There is a relationship between fatigue rate and the education level of these women (f=8.569, p=0.001) and income (f=10.72, p<0.001). When medical instructions had to be given to a patient to do less work or rest at home, the fatigue rate was significantly higher than those who did not (f=17.34, p<0.001). In conclusion, it appears that health personel working with childbearing populations should counsel women about significant 1st trimester fatigue so they can prepare their work and home environments in an attempt to achieve adequate rest. Fatigue Work Pregnancy Childbearing. 2003 5 01 35 39 http://mjiri.iums.ac.ir/article-1-720-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 A STUDY COMPARING CEREBROSPINAL FLUID LACTATE LEVELS IN CHILDHOOD CULTURE POSITIVE AND CULTURE NEGATIVE MENINGITIS M KEYHANI Despite recent innovations in the laboratory diagnosis of bacterial from nonbacterial meningitis, solid data-necessary for early determination of bacterial meningitis (BM) before organism growth in the culture medium-are missing. Therefore cerebrospinal fluid (CSF) lactate levels were evaluated as a possible means of differentiating the two clinical entities. This was a retrospective study. Patients were studied in one year. They were divided into three groups: Group one included 10 patients with culture positive meningitis Group two included 10 patients with culture negative meningitis compatible with a viral etiology Group three consisted of 10 febrile children without any biochemical or cytological CSF abnormality as the normal controls. CSF lactate level determinations were made enzymatically with Boehringer Mannheim reagents in addition to the formal biochemical and cytological investigations, consisting of cell counts and differential plus glucose and protein levels and CSF/blood glucose ratio in all three groups. Group one had a mean CSF lactate level of 12.90 (±3.08) mmol/L, while in groups 2 and 3 the level was 1.89 (± 0.52) mmoL/l and 1.63 (±0.31) mmol/L respectively. Lactate levels were significantly higher in patients from group one with respect to the control group (p= 0.001) whereas there were no significant differences between group 2 and the control group. Regarding temporal profile of CSF markers and considering the rapid rise in CSF lactate levels in bacterial meningitis, its measurement seems appealing to confirm a bacterial etiology instead of awaiting the results of CSF culture. CSF Lactate Bacterial Meningitis Non-bacterial Meningitis. 2003 5 01 29 34 http://mjiri.iums.ac.ir/article-1-719-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 SUCCESSFUL PREGNANCY OUTCOME WITH lUI IN PATIENTS WITH UNEXPLAINED RECURRENT MISCARRIAGE, WHOSE MALE PARTNERS HAVE LOW SCORE HYPO-OSMOTIC SWELLING TEST J ZOLGHADRI jzoighad@yahoo.com A GHADERI S ALBORZI ME PARSANEZHAD In order to determine outcome of pregnancy with lUI in patients with unexplained recurrent miscarriage whose husbands have low hypo-osmotic swelling test scores, a prospective clinical intervention was performed at a university referral clinic of recurrent abortion. Out of 56 patients whose husbands had abnormal hypo-osmotic swelling tests, 43 patients underwent lUI, from which only 14 patients became pregnant (treatment group) and 13 patients became spontaneously pregnant without lUI as control group. Our main outcome measure was successful pregnancy (continuation of pregnancy after 20 weeks). Among the 14 patients who became pregnant, 3 patients aborted below 20 weeks (21.4%), and 11 patients continued pregnancy after 20 weeks of gestation (78.6%). In the control group among the 13 patients with spontaneous pregnancy, 8 patients aborted below 20 weeks (61.5%) and 5 patients continued pregnancy over 20 weeks (36.4%), success rate ratio was 2.04% and the difference was statistically significant (d= 4.49, p<0.05). Treating the unexplained recurrent aborter whose male partner has a low hypo-osmotic swelling test score with lUI could be effective. This is the first study to present an ideal way for selection of recurrent aborters who benefit from lUI. The probable mechanism for this effect may be selection of the best quality sperms which will be discussed in detail. Recurrent miscarriage Hypo-osmotic swelling test lUI. 2003 5 01 25 27 http://mjiri.iums.ac.ir/article-1-718-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 ASSESSMENT OF THE RELATION BETWEEN AGE AT MENARCHE, ANTHROP OMETRIC PARAMETERS AND INTELLIGENCE QUOTIENT IN MASHHAD, IRAN Z YUSOFI N RAJAIE The present study was initiated to derive an indirect method for estimating body fat mass (BFM) and to evaluate the correlation between indirect anthropometric techniques for this estimation and to examine the relation of these parameters and of IQ to age of menarche. A total of 578 adolescent girls of ten junior high schools in five educational districts of Mashhad, participated in a cross sectional study during autumn 2000. The data were gathered through questionnaires, interview, measurement of anthropometric parameters including: weight, height, BMI (Body Mass Index), TSF (Triceps Skin Fold) thickness, SSSF (Sub-Scapular Skin Fold) thickness, MUAC (Middle Upper Arm Circumference), and measurement of IQ by Raven test. We demonstrated that anthropometric parameters for estimating BFM correlated well with each other. Age at menarche did not correlate with BFM measured by anthropometric parameters when studied at the onset of menarche, but it did well correlate negatively with these indices if studied any time postmenarche, regardless of the interval between the onset of menarche and the present age (p<0.001). IQ correlated negatively to the age at menarche (p< 0.001). These findings implicate that BFM does not trigger puberty onset in healthy girls, but it does accumulate with a faster rate in the postmenarcheal period so that girls who have an earlier menarche have a higher weight and BMI and greater skinfold thickness than those who enter the menarcheal stage at a later time, and that mental development and physical growth are parallel processes, so that a slower mental development would be expected when physical growth is delayed. Menarche BM! MUAC TSF SSSF IQ Age at Menarche. 2003 5 01 19 24 http://mjiri.iums.ac.ir/article-1-717-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 LAMOTRIGINE AS ADD-ON THERAPY IN CHILDREN WITH DRUG-RESISTANT EPILEPSY (IRANIAN EXPERIENCE) M BARZEGAR SH TONEKABONI M GHOFRANI Lamotrigine (LTG), a newly developed antiepileptic drug (AED), is efficacious in treating refractory epilepsy. This study was designed to evaluate the efficacy and safety of LTG as add-on therapy in 40 children with refractory epilepsy. The trial was an open-labeled prospective study in children with drug-resistant epilepsy aged Lamotrigine refractory epilepsy add-on therapy. 2003 5 01 15 18 http://mjiri.iums.ac.ir/article-1-714-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 LYMPH NODE REVEALING SOLUTION: A NEW USEFUL METHOD FOR ISOLATION OF MINUTE AXILLARY LYMPH NODES IN BREAST CANCER B GERAMIZADEH A RAZAVI Breast cancer is one of the most common malignancies in the world. The most important prognostic factor in this cancer is the stage of the tumor. Detection of lymph nodes with or without malignancy is essential for determining the stage of the tumor and setting a therapeutic plan. There are different methods for isolating lymph nodes in surgical specimens of breast cancer in the pathology department. The most popular method is routine palpation, but isolation of very small lymph nodes is difficult and time consuming and some may be missed. The main goal of this paper is to describe a new, precise and easy technique for finding nodes in breast cancer specimens. In this study 50 cases of breast cancer were randomly selected. In these cases axillary fat was examined for lymph nodes by traditional method, and then the entire axillary fat was immersed overnight in a lymph node revealing solution (LNRS) composed of various traditional fixatives and fat solvent. After overnight fixation the lymph nodes stood out as white chalky nodules on the background of yellow fat. They were then excised, processed and stained by routine H;E method. The total number of lymph nodes found by traditional method in these 50 cases was 660. After application of LNRS, 178 additional lymph nodes measuring from 0.5 to 9 mm were found. The LNRS increased the mean number of nodes per case from 13.20+/-6.61 found by traditional method to 16.67+/-7.64 nodes per case (p value<O.01). The size of lymph nodes identified by LNRS was significantly smaller than those found by traditional method (p value<O.OI). In 8 cases, tumor stage was increased by application of LNRS in addition to routine palpation. As a whole LNRS is a useful, rapid and good fixative. It significantly enhances the yield of lymph nodes in the axillary fat of breast cancer specimens. 2003 5 01 11 14 http://mjiri.iums.ac.ir/article-1-713-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 A CROSS-SECTIONAL CONTROLLED STUDY OF GONADAL FUNCTION AND PUBERTAL DEVELOPMENT IN THALASSEMIA MAJOR AA VAHIDI MH TORABINEJAD A AHMADI Z FARAHMANDINIA G KIANI MOGHADDAM ghasemkiani@yahoo.com B MEGHDADI Early and regular blood transfusion therapy in patients with homozygous beta-thalassemia decreases the complications of severe anemia and prolongs survival. In the long term, however, the beneficial effects of transfusions are limited by the organ damage resulting from iron overload. Endocrine complications in patients with thalassemia major in developing countries may be frequent due t o suboptimal iron chelation. T he goal of this study was to investigate the gonadal function and secondary sex characteristics in thalassemic patients. We studied 71 randomly selected adolescent thalassemic patients and 30 age- and sex-matched controls. Sexual maturity rating (SMR), height and weight, and gonadotropin, sex steroid, and ferritin levels were evaluated. Cases had significantly lower mean height and weight. Also, serum levels of gonadotropins and sex hormones were significantly lower in cases with thalassemia than in controls. Gonadotropin and sex steroid levels were lower in cases with thalassemia who had not used deferoxarnine regularly compared to those with a regular chelation therapy regimen. All of the control subjects had sexual maturity ratings of II or above, while 36.6% of thalassemic cases were in Tanner stage I. About 53.3% of controls had surpassed all levels of sexual maturity, while only 2.8% of cases were in the stage SMR V. Distribution of SMR ratings was significantly different in cases and controls. These findings clearly show that a high percentage of thalassemic patients in this part of the country suffer from various endocrine abnormalities, especially impairment in height growth and sexual maturity. It is wise to consider more sophisticated treatment modalities in these patients, including the administration of sex hormones for the compensation of hormonal abnormalities resulting from hemosiderosis. β-thalassemia major endocrine function puberty 2003 5 01 5 10 http://mjiri.iums.ac.ir/article-1-711-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2003 17 1 LIVING-RELATED LIVER TRANSPLANTATION IN CHILDREN: THE SHIRAZ EXPERIENCE SA MALEK-HOSSEINI M LAHSAIE H SALAHI A BAHADOR M HAGHIGHAT MJ KAVIANI MB KHOSRAVI M BORZOIE M ARASTEH MH BAGHERI M FATTAHI HR DAVARI S NIK-EGHBAL A KARBASSI The liver transplantation program was established at Shiraz Nemazee Hospital in 1993. Shortage of cadaver organ supply due to various social and legal issues urged us to develop a living-related liver transplantation (LRLT) program. So far 7 (6 males, 1 female) living-related liver transplantations have been performed at this center. The mean age of patients was 8.21 years (+/- 4.16), with a range of 4.5 to 14 years. Live donors (3 mothers, 2 fathers, and 1 brother) with a mean age of 30.83 years (+/- 4.11) underwent procurement of the left lateral segment without mortality or any serious morbidity. The native liver disease was idiopathic cirrhosis (1 case), biliary atresia (3 cases), Budd-Chiari syndrome (1 case), neonatal cirrhosis (l case), and cryptogenic cirrhosis (l case). Allografts were implanted using piggy-back surgical technique. Baseline immunosuppression consisted of a triple drug regimen including cyclosporine, mycophenolate mofetil and steroids. Acute graft rejection was treated with intra-venous bolus of methyl-prednisolone. Early death occurred in 2 patients due to vascular thrombosis. Biliary complication was observed in 1 patient. Five patients are alive with a normal functioning liver. In conclusion, LRLT program is promising in Iran. It can help to overcome the shortage of organs and minimize the mortality of patients in the waiting list. Liver transplantation Living-related Children 2003 5 01 1 3 http://mjiri.iums.ac.ir/article-1-710-en.pdf