2024-03-29T02:43:57+04:30
http://mjiri.iums.ac.ir/browse.php?mag_id=51&slc_lang=en&sid=1
51-889
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
AN UNUSUAL ADNEXAL TUMOR WITH DIFFERENTIATION TOWARDS HAIR FOLLICLE, WITH CONCOMITANT PRESENCE OF TRICHOFOLLICULOMA, TRICHOEPITHELIOMA AND PILOMATRICOMA IN ONE LESION: A CASE REPORT
GUITI
lRAVANLOU
FATEMEH
MAHJOUB
A case of an interesting previously unreported mixed adnexal tumor of the
scalp of a 38 year old man is presented, which was composed of randomly dispersed
areas of trichofolliculoma, trichoepithelioma, and pilomatricoma concomitantly.
While these lesions are classified under adnexal tumors with differentiation
towards hair follicle structures, controversy is present concerning the exact
origin and the pathway of their differentiation. So the concomitant presence of
them in one lesion may be strong evidence for a common origin or a common
direction of differentiation.
Trichofolliculoma
Trichoepithelioma
Pilomatricoma
Adnexal tumor
Hair follicle structures.
2000
8
01
191
194
http://mjiri.iums.ac.ir/article-1-889-en.pdf
51-888
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
GIANT HAMARTOMA OF THE BREAST: REPORT OF A CASE AND REVIEW OF THE CURRENT LITERATURE
D
FARROKH
Hamartoma of the breast is a rare benign breast lesion which is unfamiliar to
most clinicians, although the mammographic features are usually characteristic.
Hamartomas are composed of ducts, lobules, fat and fibrous tissue. These benign
lesions are likely to be increasingly diagnosed because of routine screening and
hence clinical awareness is paramount to prevent these lesions from being overtreated.
A patient who presented with a soft mobile breast lump which was later
diagnosed to be a giant breast hamartoma is presented along with a brief review
of the current literature.
2000
8
01
187
189
http://mjiri.iums.ac.ir/article-1-888-en.pdf
51-887
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
ISOLATED CEREBRAL METASTASIS OF HEPATOBLASTOMA IN A 3-YEAR OLD CHILD
A
A. EBRAHIMI NEJAD
A
ZAREE
Hepatoblastoma (HB) is a rare tumor of infancy and childhood manifesting
with hepatomegaly and abdominal distention. It is seen with increased frequency
in association with congenital hemihypertrophy and renal anomalies. Metastases
to other organs, including the lungs, lymph nodes and even ovaries is well known.
But cerebral metastasis of this tumor, especially in the absence of metastasis to
other organs, has not yet been reported. In this paper a 3-year old male child with
congenital hemihypertrophy and isolated metastasis of HB to the brain is presented.
Cerebral metastasis
Hepatoblastoma (HB).
2000
8
01
185
186
http://mjiri.iums.ac.ir/article-1-887-en.pdf
51-886
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
MELAS SYNDROME IN TWO IRANIAN CHILDREN
M
GHOFRANI
GR
ZAMANI
MELAS syndrome is a mitochondrial disorder with progressive nature, because
adequate treatment is not available. Diagnosis of this mitochondrial disorder
depends initially on clinical suspicion, which is strengthened by additional
metabolic evidence of impaired oxidative metabolism such as high serum or C.S.F.
lactate levels and confirmed by demonstration of mitochondrial abnormalities-in
muscle biopsy. Here we present the clinical course and management of two children
with MELAS syndrome who exhibited progressive neurologic deterioration.
MELAS syndrome
mitochondrial disorders.
2000
8
01
181
184
http://mjiri.iums.ac.ir/article-1-886-en.pdf
51-885
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
SUPPRESSION OF VLDL-TRIACYLGLYCEROL SECRETION B Y BOTH α AND β-ADRENOCEPTOR AGONISTS IN ISOLATED RAT HEPATOCYTES
M
RASOULI
mehdi.rasouli@planetaccess.com
M
SHARIF
M
ZAHRAIE
The effects of alpha and beta-adrenergic stimulation on triacylglycerol secretion
were investigated in isolated rat hepatocytes. Epinephrine within 3h of incubation
suppressed triacylglycerol secretion by 35% and increased its cellular content
by 18%. The inhibitory effect of epinephrine was abolished by inclusion of
phentolamine and also prazosin but not with propranolol. Trifluoperazine concealed
the inhibitory effect of epinephrine in a dose-dependent manner, whereas
theobromine did not have any significant effect. The secretion of triacylglycerol
was suppressed not only by the a-agonist phenylephrine but also by the β-agonist
isoproterenol. Dibutyryl-cyclic AMP also inhibited secretion of triacylglycerol
by approximately 30%. The results indicate that epinephrine suppressed
triacylglycerol secretion via the α1-adrenoceptor whereas stimulation of beta-as
well as alpha-adrenoceptors can exert a similar effect. Calcium-calmodulin dependent
protein kinase may be involved in the down-regulation of VLDL secretion.
The unexpected effect of isoproterenol has been discussed in relation to
"dual signaling" and also the "store-dependent calcium entry" hypotheses.
Adrenoceptor
Epinephrine
Isoproterenol
Triacylglycerol
VLDL.
2000
8
01
175
180
http://mjiri.iums.ac.ir/article-1-885-en.pdf
51-884
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
CYTOGENETIC EFFECTS OF MAGNETIC AND RADIOFREQUENCY FIEL DS OF NMRI SYSTEMS ON THE FREQUENCY OF CHROMOSOMAL ABERRATIONS INHUMAN LYMPHOCYTES IN THE PRESENCE OR ABSENCE OF CYTOSINE ARABINOSIDE
H
MOZDARANI
Mozdarah@Netlcs.Modares.ac.ir
MR
TOHIDNIA
Application of nuclear magnetic resonance imaging (NMRI) as a non-invasive
and accurate imaging procedure has been widely used in recent years. Meanwhile,
the biological effects of magnetic fields of several tesla (T) and high energy
radiofrequency (RF) is not fully known yet. Because of controversy over this
issue, the present research has been carried out in order to verify the effects of
magnetic fields of 1.5 T and RF of 63.86 MHz on the frequency of chromosomal
aberrations in human peripheral lymphocytes.
Using metaphase analysis technique, the cytogenetic effects of NMRI was
studied in GO and G2lymphocytes in the presence or absence of cytosine arabinoside
(ara-C) as a DNA repair inhibitor. Cells were cultured using conventional
methods.
Results obtained indicate that exposure of lymphocytes to NMRI field at 30
and 60 minutes has no potential effects on chromosomal aberration induction.
When using ara-C, although ara-C alone caused a rather high frequency of chromosomal
aberrations, especially in G2 phase of the cell cycle, exposure of cells to
NMRI in the presence of ara-C did not change the frequency of ara-C-induced
damage significantly.
Our results indicate that NMRI may not be able to produce DNA damage
that could be potentiated by ara-C. Similar responses were also observed for cells
exposed to NMRI either in vivo or in vitro. Nevertheless much remains unknown
about the certain effects of MRI and RF.
NMRI system
Chromosomal aberrations
Human lymphocytes
Cytosine arabinoside
2000
8
01
169
173
http://mjiri.iums.ac.ir/article-1-884-en.pdf
51-883
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
COMPARATIVE CHARACTERIZATION OF PORINS FROM SALMONELLA TYPHIO-901 AND SALMONELLA TYPHIMURIUM RA-30
BAHMAN
TABARAIE
BALK
SHARMA
MEHDI
NEJATI
HOJAT
AHMADI
PARVEEN
SHARMA
NIRMAL K.
GANGULY
Porins from Salmonella typhi 0-901 and Salmonella typhimurium Ra-30 were
characterized and compared. The elution profile of porins from these salmonella
species on Sepharose-48 and HPLC appear to be very similar. The findings were
confirmed by the electrophoretic pattern which showed three types of porins, i.e.
OmpC, OmpD and OmpF in both species. These porins appear to be similar, if not
identical, as the LPS-absorbed antiporin antibodies reacted with homologous as well
as heterologous antigens. The results of this study favour the use of porins as a
common immunogen to control salmonellosis since porin patterns were found to be
quite similar among the serotypes of salmonellae, unlike other enterobacterial
species.
Porins
S. typhi
S. typhimurium.
2000
8
01
161
168
http://mjiri.iums.ac.ir/article-1-883-en.pdf
51-882
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
SUSCEPTIBILITY OF HUMAN WM MELANOMA CELL LINES TO NK AND LAK CYTOTOXICITY AND THEIR RELEVANCE TO THE LEVEL OF MHC CLASS I AND ICAM-l ANTIGEN EXPRESSION
AR
ANDALIB
J
LAWRY
R.c
REES
The effect of natural killer (NK) cells and lymphokine activated killer
( LAK) cells was studied on a group of human melanoma cell lines. Peripheral
blood from healthy volunteers was utilized as a fresh source of natural killer
cells and rhI L-2 for producing LAK cells. The cytotoxicity of effector cells
was quantified using a 4 hour SI determining the density of antigen expression on tumor cell surface. The majority
of WM melanoma cell lines were relatively resistant to lysis by NK
cells, but all showed high sensitivity to LAK cytotoxicity. The expression of
MH C class I and I CAM-l on tumor cell lines varied, however using linear
regression analysis between MH C class I and I CAM-l antigen expression,
and UK/ pression of these antigens on the WM melanoma cell lines tested are independent
of NK/
2000
8
01
155
160
http://mjiri.iums.ac.ir/article-1-882-en.pdf
51-881
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
EFFECTS OF CHOLECYSTOKININ RECEPTOR ANTAGONISTS ON MORPHINE- AND COCAINEINDUCED HYPOTHERMIA
M
REZAYAT
M
GHAZI-KHANSARI
B
MOUSTAFAVI-MEHR
MR
ZARRINDAST
The effects of cholecystokinin (CCK) receptor antagonists on hypothermia
induced by cocaine or morphine have been studied in mice. In the present work,
subcutaneous (SC) injection of cocaine (50-150 mg/kg) or morphine (125-500
mg/kg) induced hypothermia in mice. Administration of CCKA receptor antagonist
MK-329 (0.5-1.5 mg/kg), CCKB receptor antagonist L-365, 260 (0.5-1.5 mgl
kg) and CCK receptor antagonist proglumide (15-45 mg/kg) 60 min. prior to cocaine
injection reduced hypothermia induced by cocaine. MK-329 or proglumide
also reduced the morphine response. Single administration of MK-329 and L-
365,260 to mice decreased mice core body temperature. It is concluded that the
hypothermic effect of cocaine and morphine may be mediated through CCKA and
CCKB receptor mechanism(s).
CCK antagonists
cocaine
morphine
hypothermia
mice.
2000
8
01
151
154
http://mjiri.iums.ac.ir/article-1-881-en.pdf
51-880
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
CONTRACTIONS DUE TO α-ADRENOCEPTOR AGONISTS ARE MEDIATED BY α1-ADRENOCEPTORS IN RAT CAROTID ARTERY
M
MOHAMMADI NAGHADEH
J.e
McGRATH
Some large vessels have a mixed functional population of postjunctional α1-
and α 2-adrenoceptors. The purpose of the work presented here was to investigate
the population of postjunctional α -adrenoceptors in the rat isolated common carotid
artelY Male Wi star rats were killed by overdose with pentobarbitone sodium,
after which the left and right common carotid arteries were removed. Rings
of arteries 3-4 mm in length were cut from each vessel and then mounted in 10
mL isolated organ bath, bathed in Krebs maintained at 37°C and gassed with 95%
O2 plus 5% CO2, The preparations were allowed to equilibrate for an hour. When
antagonists were used, the preparations were incubated for at least 45 minutes
with the drugs prior to the onset of a second CCRC. The cunent study focused on
the possibility of post junctional α 2-adrenoceptors that could influence adrenergic
system-mediated vascular α -adrenoceptor responsiveness in this cephalic artery.
The dominance of α 1-adrenoceptors is shown by the high sensitivity of noradrenaline
or phenylephrine to prazosin and the ineffectiveness of rauwolscine, except
in non-selective concentrations. UK-14304 produced contractions and it is
theoretically possible that UK-14304 exerts its actions through combined al and
α 2 activation, but the effectiveness of prazosin and the ineffectiveness of
rauwolscine, except in non-selective concentrations, shows that even this effect is
mediated through α1-adrenoceptors. Thus we suggest that the population of
postjunctional α -adrenoceptors mediating contraction of smooth muscle in the
rat carotid artery is predominantly of the α1type.
α -adrenoceptors
prazosin
UK-14304
2000
8
01
145
149
http://mjiri.iums.ac.ir/article-1-880-en.pdf
51-879
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
NEUROLOGIC AND PSYCHOLOGIC COMPLICATIONS AFTER KIDNEY TRANSPLANTATION
FARAHNAZ
FALLAHIAN
MOHAMMAD REZA
KHATAMI
PARVIZ
JABAL AMELI
Neurologic and psychologic complications are usually related to drug toxicity,
infections or symptoms induced by deterioration of renal allograft function.
Metabolic encephalopathy, hypertensive encephalopathy, cerebrovascular events,
and new-onset seizures have all been reported in organ-transplant recipients. Infections
can be caused by listeria, cryptococcus, nocardia, aspergillus and mucor.
Toxoplasma, coccidia, cytomegalovirus (CMV) and herpes infections are also
reported. Cerebral hemorrhage can occur secondary to septic emboli or intracerebral
aneurysms. The aim of this study is to present the results of a review on 200
renal transplant recipients concerning neuropsychologic complications during a
12-year period in the Imam Khomeini Hospital affiliated to Tehran University of
Medical Sciences.
According to this study, neuropsychologic disorders occurred in 3 a (15%) of
the recipients and of these, peripheral neuropathy, depression and tremor were the
most common and were detected in 8 (4%), 5 (2.5%), and 4 (2%) of the recipients,
respectively.
Kidney transplantation
Neurologic complications; Psychologic complications; Immunosuppression.
2000
8
01
141
143
http://mjiri.iums.ac.ir/article-1-879-en.pdf
51-878
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
ROLE OF IRON DEFICIENCY ANEMIA IN CHILDBEARING WOMEN ON NEONATAL WEIGHT
S
SHAMSI
AM
GOODARZI
Iron deficiency is one of the most common nutritional problems in the
world, It is frequently found in both developed and developing countries and
mainly affects women of childbearing age. The aim of this study was to investigate
the relationship of iron deficiency anemia in pregnant women on neonatal
weight. The study subjects were a group of 241 women aged between 20
and 34 years who were divided to anemic (118 subjects as case) and nonanemic
(123 subjects as control) groups. Iron deficiency anemia was determined
by measurements of plasma ferritin, T.I.B.C., total iron, hemoglobin
and hematocrit, and subsequently the weight of the neonate was also determined.
Results showed that depleted iron stores in the anemic group has no
statistically significant effect on neonatal weight (t-test= 0.73, D,F.= 239,p>t=
0.4654).
Lower, depleted iron stores were observed in the anemic group with high
parity and decreased intervals of pregnancy. It is concluded that the occurrence
of iron deficiency anemia in pregnant women during the third trimester
has no relationship with neonatal weight, but according to some published
results this relationship exists during the first trimester.
Anemia
Iron deficiency
Pregnancy anemia.
2000
8
01
137
140
http://mjiri.iums.ac.ir/article-1-878-en.pdf
51-877
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
PREDICTION OF ESTROGEN RECEPTOR STATUS OF INVASIVE DUCTAL CARCINOMA OF BREAST BY HISTOLOGIC GRADE
F
TIRGARI
ALI
ZARE MEHRJARDI
GUITY
IRAVANLOO
In human breast cancer, estrogen receptor (ER) status of the tumor has prognostic
and therapeutic significance. However, facilities to study ER are not widely
available to us. We postulated that if there is a correlation between histologic
grade and ER status of invasive ductal carcinoma (IDC), it may help predict the
ER status of the tumor. Of 8 4 cases of breast carcinoma referred to the Cancer
I:q.stitute of Tehran for immunohisto logic study of ER in 1995, 69 cases of IDC
that had adequate H & E stained slides were chosen. Using the Nottingham modifi.
cation of the Bloom-Richardson grading system of IDC, all cases were scored
by each of us separately. Conflicting cases were jointly reassessed until a consensus
was reached. Sections of paraffin blocks were stained for ER using the avidinbiotin
complex method and then they were assessed by a digital image analyzer.
There was an inverse relationship between ER positivity of tumors and each
of the grading parameters and the•ultimate grade that were all statistically significant
(p<0.0001). Moreover, further analysis revealed that low histologic grade
(with scores of3 or 4) had a 92.3% positive predictive value (range 62.9%-98 .2%)
for ER positivity. Similarly, histologic grade-=-in the presence of score 3 nuclei-had
an 83.9% positive predictive value (range 71.2%-91.9%) of ER negativity in tumor
cells. These findings suggest that in tumors with histologic grades at both
ends of the spectrum, ER status may reliably be predicted in a significant number
of cases.
Breast carcinoma
invasive ductal carcinoma
estrogen receptor
histologic grading.
2000
8
01
133
135
http://mjiri.iums.ac.ir/article-1-877-en.pdf
51-876
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
RUPTURE OF URINARY BLADDER: AN EXPERIENCE WITH 55 CASES IN SHIRAZ
MR
FATTAHI
AA
KHEZRI
We reviewed 55 cases with trauma to the urinary bladder. Blunt trauma was
the cause of injury in 78 percent of cases and associated pelvic fracture was present
in 75 percent. Eighty percent of extraperitoneal ruptures were associated with
fracture of the pelvis. The most common cause of trauma was car accident (63%),
followed by war injury (20%).
Nearly two-thirds of patients (63 %) had extraperitoneal rupture.
The most common presentation was gross hematuria (49%), followed by
abdominal pain and tenderness (38%). In 24 patients, diagnosis was made by
retrograde cystography, in 9 patients by intravenous pyelography and the remaining
patients were diagnosed by physical examination and diagnostic laparotomy.
All of the patients were treated by surgical repair. Mortality rate was
two percent.
Bladder
Rupture
Extraperitoneal
Intraperitoneal
Trauma
Pelvic fracture.
2000
8
01
127
131
http://mjiri.iums.ac.ir/article-1-876-en.pdf
51-875
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
SUBMICROSCOPIC DELETIONS OF THE Y CHROMOSOME ARE NOT LIMITED TO AZOOSPERMIC MEN, BUT ARE ALSO DETECTED IN INFERTILE MEN WITH IDIOPATHIC OLIGOZOOSPERMIA
H
NAJMABADI
Hnajm@.navara.com
DM
De KRETSER
S
ARVER
W
TAYLOR
C
MALLIDIS
HW
GORDEN BAKER
RI
McLACHLAN
KA
LOVELAND
L
RAMIREZ
A
NIEVA
M
GUTIERREZ
B
SUH
S
SAHEBJAM
F
SAHEBJAM
S
BHASIN
It is now agreed that 10-25% of infertile men with azoospermia have submicroscopic
deletions of the Y chromosome long ann (yq), consistent with the proposed location of the
azoospermia locus (AZF) in Yq 11.23. However, it is not known whether Yq microdeletions
are unique to men with azoospermia or whether they are also observed in infertile men with
less severe defects of spermatogenesis (oligozoospermia). The objective of this study was to
determine the prevalence of Yq deletions in infertile men with idiopathic oligozoospermia
DN A was extracted from blood lymphocytes of 45 oligozoospermic men (sperm
densities <20 million/mL) in whom known causes of infertility had been excluded. All
subjects were typed for the 27 Y -specific STSs that have been mapped to deletion interval
6. An STS was considered negative if no PCR product was observed in 3 reactions, in
which a fertile male gave a specific PCR product and anorma1 female DNA did not. Whenever
sufficient DNA was available, deletions detected by PCR were verifed by Southern
hybridization.
Of the 45 oligozoospermic men, 4 (9010) had deletions of one or more STSs. These
deletions were verified by Southern hybridization. All. 4 deletions were located in distal
interval 6 (6C and 6D) and included the DAZ (Deleted in Azoospermia) gene, a Y-specific
gene that has been proposed as a candidate for male infertility. All four patients had sperm
densities of less than 1 million/mL and three out of these 4 patients had mean testis volume
of less than 15 mL. Two of the infertile men with Y deletions had a testicular biopsy
testicular histology in both of these patients was consistent with germ cell arrest, spermatocyte stage.
Yq microdeletions are not unique to infertile men with azoospermia but are abserved
also in infertile men with oligozoospermia Taken together with previously reported
studies on azoospermic men, these results indicate that Yq deletions are predominantly
obselVed in, but are not limited to, infertile men with relatively severe defects of spermatogenesis.
Oligozoospermia
Idiopathic infertility
Yq deletions
DAZ gene
REM gene
Azoospermia
2000
8
01
119
125
http://mjiri.iums.ac.ir/article-1-875-en.pdf
51-874
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
CHANGES IN BLOOD LEVELS OF TRACE ELEMENTS AND ELECTROLYTES IN HYP ERTENSIVE PATIENTS
M
MOMTAZ
N
MUGHAL
AZHAR
SIDDIQUE
TABASSUM
MAHBOOB
The involvement of elements in the pathological process of primary hypertension
has been established. The serum levels of copper, iron, zinc, sodium,
potassium and calcium were studied by atomic absorption spectrophotometery
and flame photometry in hypertensive and normal subjects. Serum copper and
zinc levels were increased in hypertensive patients (25.5% and 14.7% respectively)
as compared to normal subjects. A decrease in serum sodium (21".9%),
potassium (31.02%), iron (44.7%) and calcium (34.23%) was observed in hypertensive
as compared to control subjects. The role of these serum element variations
and their possible involvement in hypertension is discussed.
2000
8
01
115
118
http://mjiri.iums.ac.ir/article-1-874-en.pdf
51-873
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
PROGNOSTIC VALUE OF MYELOID ANTIGEN EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKEMIA
Z
AMIRGHOFRAN
amirz@sums.ac.ir
A
SHAMSEDDIN
M
SHAHRIARI
Expression of cell surface molecules associated with lymphoid and myeloid
lineage differentiation on the blasts of 53 patients with acute lymphoblastic leukemia
(ALL) was investigated. 1.9% of cases were only HLA"7DR+ 7.6% were
HLA-DR+, CDI9+ 22.6% were HLA-DR+, CDI9+, CDI0+ 30.2% were HLADR+,
CDI9+, CDlO±, CD20+ and 37.7% were HLA-DR±, CD7+, CD5±. Aberrant
expression of one or more myeloid antigens including CDI3, CDI5, CD33
and CD34 was found in 30.2% of cases. The relationship of myeloid positive
(MY+ ALL) and negative cases (MY- ALL) with patient characteristics were
studied. No significant differences in clinical features, response to therapy or survival
was found between the two groups. Study of each marker separately indicated
an association between expression of CD5 and CD 1 0 with age and expression
of CD20 and CD33 with decrease in hemoglobin (p<0.03). No correlation
between expression of markers and survival was found except for CD 13 and CD 15
antigens (p<0.03). CDI5+ cases showed longer survival than negative cases
(541±72 vs. 364±34 days) whereas CDI3+ cases showed shorter survival than
negative ones (378±32 vs. 616±,106). showed a trend towards a longer or shorter survival.
Myeloid antigens
Acute lymphoblastic leukemia
Myeloid positive ALL.
2000
8
01
111
114
http://mjiri.iums.ac.ir/article-1-873-en.pdf
51-872
2024-03-29
10.1002
Medical Journal of The Islamic Republic of Iran (MJIRI)
Med J Islam Repub Iran
1016-1430
2251-6840
10.18869/mjiri
2000
14
2
DIAGNOSTIC VALUE OF MEAN PEROXIDASE INDEX IN EARLY KAWASAKI DISEASE
N
NAKHAEE
A
SADEGHI-HASSANABADI
HR
TABATABAEE
The charts of 27 patients with Kawasaki disease (KD) admitted to Nemazee
Hospital in Shiraz from January 1991 to October 1998 were reviewed to identify
the results of mean peroxidase index (MPXI) values, a measure of neutrophil
staining intensity, obtained by the Technicon HI analyzer (Technicon Instruments
Corp., Tarrytown, NY) within the first 10 days of the illness 2 separate groups of
patients were assessed as control subjects: 27 disease control (DC) children with
fever plus one other KD criterion and 27 laboratory control (LC) subjects with
nonfebrile disorders interpreting also as a normal reference population. Compared
with control groups, patients with KD had lower quantities of MPXI
[(Mean±SD, -11.71±5.87 in KD group) vs. (1.53±4.30 p<0.001 in DC group,
and 1.74±6.52,p<0.001 in LC group)]. Depending on the location of the cut-off
point expressed on an interval scale, this test had the ability to be 100% specific
( if MPXI0).
Considering the low prevalence of hereditary myeloperoxidase (MPO) deficiency
( 1 in 2000), measurement of MPXI, when performed as part of a complete
count on an automated hematology instrument, could be counted as an important
adjunct to clinical evaluation and also according to the low values of MPXI in patients
with KD, it can be included among the acquired causes of MPO deficiency.
Acute phase
Mucocutaneous lymph node syndrome
Myeloperoxidase deficiency.
2000
8
01
107
110
http://mjiri.iums.ac.ir/article-1-872-en.pdf