2024-03-28T22:19:02+04:30 http://mjiri.iums.ac.ir/browse.php?mag_id=53&slc_lang=en&sid=1
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 THE SPECTRUM OF BETA – THALASSEMIA MUTATIONS IN IRAN A A. MERAT M HAGHSHENAS 2000 5 01 103 106 http://mjiri.iums.ac.ir/article-1-911-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 SPERMATIC CORD HEMATOMA MIMICKING SPERMATIC CORD TORSION IN A NEONATE ALI SHAMSA Acute scrotal swelling is an urgent urologic condition, and its failure in diagnosis is "one of the litigious issues in urologic practice. "1-2 Although acute scrotal pain is due to spermatic cord torsion in 25-35% of cases, the urologist should either rule it out or treat it immediately. 2 We operated a case of acute scrotal edema in a two-day-old boy who had, according to clinical results and color Doppler imaging, been diagnosed as having spermatic cord torsion. Operation, however, confirmed that the cause was spermatic cord hematoma, not torsion. 2000 5 01 101 102 http://mjiri.iums.ac.ir/article-1-910-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 IN TRACRANIAL SUPPURATION FOLLOWING NEUROSURGICAL PROCEDURES DUE TO BRUCELLA SPECIES SEYED ALI F. TABATABAI HOOSHANG SABERI MASOUD MEHRAZIN Reported here are two cases of delayed postsurgical brucella abscess within the cranium, treated successfully by reoperation and appropriate medical therapy. Both patients had an occupational exposure to the pathogenic organism. Systemic symptoms of brucellosis became manifest postoperatively in case I and were present in case II long before operation. The diagnosis was confirmed by serology and positive culture. Later an intracranial abscess developed in both cases at the previous operative sites. Hematogenous spread of bacteria to the locally low resistance host tissue was speculated as the possible mechanism. Successful management was accomplished by reoperation, comprised of local drainage and debridement followed by a combined anti brucella drug regimen for a period of 6 months. Brucellosis. Brain abscess Local host resistance Postoperative infection. 2000 5 01 97 100 http://mjiri.iums.ac.ir/article-1-909-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 BULL ET-INDUCED FALSE ANEURYSM OF THORACIC AORTA WITH A TEN YEAR LATENCY PERIOD IN A VICTIM OF THE IRAN-IRAQ WAR: REPORT OF A CASE B AMINMANSOUR A TABATABAI Traumatic false aneurysm of the thoracic aorta is not uncommon. But accordingly this case is unusual in its ten year delay between injury and presentation and treatment. A victim of the Iran-Iraq war is presented with a false aneurysm of the thoracic aorta ten years after a bullet injury to the chest and thoracic spine. Penetrating chest wounds, mechanisms of injury and diagnosis are also discussed in detail. False aneurysm of aorta penetrating chest trauma bullet injury 2000 5 01 93 95 http://mjiri.iums.ac.ir/article-1-908-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 INFLUENCE OF ENDO THELIUM REMOVAL AND LNAME ON RESPONSES OF RAT COMMON CAROTID ARTERY TO α-ADRENOCEPTOR AGONISTS M MOHAMMADI NAGHADEH J.e. McGRATH In this study we investigated the effects of endothelium removal and L-NAME on responses to α-adrenoceptor agonists. Male Wistar rats were killed by overdose with pentobarbitone sodium, after which the left and right common carotid arteries were removed. Rings of arteries 3-4 mm in length were cut from each vessel and then mounted in 10 mL isolated organ bath, bathed in Krebs maintained at 37°C and gassed with 95% 02 plus 5% CO2, The preparations were allowed to equilibrate for an hour. L-NAME was added approximately 10-15 min prior to the onset of cumulative concentration-response curves (CCRC) to an agonist. In some preparations the endothelial layer was removed mechanically by gently rolling the tissue around a thin wire. Removal of the endothelium was confirmed pharmacologically by a lack of relaxant response to the potent endotheliumdependent vasodilator acetylcholine. Inhibition of NO synthesis by L-NAME results in significant vasoconstriction. L-NAME prevented the relaxation of rat carotid artery by acetylcholine, suggesting that both basal and stimulated release of nitric oxide can regulate vascular tone in this artery. Mechanical disruption of the vascular endothelium reduced, but did not abolish, the ability of L-NAME to produce contraction. This suggests an extra-endothelial site for nitric oxide synthesis in rat common carotid artery. Inhibition of nitric oxide synthase with LNAME potentiated responses to phenylephrine and UK-14304 but not to noradrenaline. Mechanical disruption of the vascular endothelium potentiated responses to UK-14304, phenylephrine and noradrenaline. We suggest that constitutive NO activity has substantial inhibitory influence on vasoconstrictor responses to phenylephrine and UK-14304 but not to noradrenaline. Endothelium L-NAME α-adrenoceptor agonists NO. 2000 5 01 87 91 http://mjiri.iums.ac.ir/article-1-906-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIM AL MODEL HA SHAHRIARI A HOSSEINI RAD In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced retinopathy, ERG waves were compared before and after methanol intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups received 4 g/kg of methanol intraperitoneally. In addition, the second, third and fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin B12 and folic acid, respectively. Baseline ERGs were recorded for all rabbits prior to intoxication and then second ERGs were taken 48-72 hours following methanol toxicity. Compared to baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in the oscillatory potential were noticed. Among all groups, the first group had the most and the fourth group had the least decrease in b-wave amplitude as well as oscillatory potential. It is therefore believed that vitamin B12 has a synergistic effect with folic acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are needed to evaluate these effects in humans. 2000 5 01 83 86 http://mjiri.iums.ac.ir/article-1-907-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 PREVENTIVE EFFECTS OF VITAMIN B12 AND FOLIC ACID IN METHANOL-INDUCED RETINOPATHY IN AN ANIMAL MODEL HA SHAHRIARI A HOSSEINI RAD In order to identify the effects of vitamin B 12 and folic acid in reducing methanolinduced retinopathy, ERG waves were compared before and after methanol intoxication in rabbits. In this study 34 rabbits were divided into 4 groups. All groups received 4 g/kg of methanol intraperitoneally. In addition, the second, third and fourth groups received vitamin B 12 injection, oral folic acid and a mixture of vitamin B12 and folic acid, respectively. Baseline ERGs were recorded for all rabbits prior to intoxication and then second ERGs were taken 48-72 hours following methanol toxicity. Compared to baseline ERGs a severe reduction in the b-wave amplitude as well as reduction in the oscillatory potential were noticed. Among all groups, the first group had the most and the fourth group had the least decrease in b-wave amplitude as well as oscillatory potential. It is therefore believed that vitamin B12 has a synergistic effect with folic acid in attenuating ophthalmic toxicity of methanol in rabbits. Further studies are needed to evaluate these effects in humans. 2000 5 01 83 86 http://mjiri.iums.ac.ir/article-1-905-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 ANTINOCICEPTIVE EFFECT OF ELAEAGNUS ANGUSTIFOLIA FRUIT IN MICE HOSSEIN HOSSEINZADEH MOHAMMAD REZA TAHERI The antinociceptive effect of Elaeagnus angustifolia fruits was studied in mice. The antinociceptive effect of ethanolic and boiling water extracts was studied using two thermal stimuli, the hot-plate and tail-flick tests. The intraperitoneal and oral administration of the ethanolic extract of seed 0.75-7.00 g/kg), but not pericarp and medulla had significant antinociceptive activity in the hot-plate test. Naloxone pretreatment did not inhibit the antinociceptive activity of the extract. The aqueous extract of different parts of the fruit (seed, medulla and pericarp) had antinociceptive activity in this test. The ethanolic extract of the seed had no antinociceptive effect in the tail-flick test and its effect was not abolished by naloxone. A 70% failure rate in the traction test (a muscle relaxation test) was induced by ethanolic extract of the seed (3.5 g/kg), compared with the 75% induced by the reference drug diazepam (2.5 mg/kg). It is concluded that the antinociceptive effect of E. angustifolia may be mediated by a supraspinal effect and muscle relaxation activity. Elaeagnus angustifolia; Antinociceptive activity; Muscle relaxation Hot-plate Tail-flick Traction test Medicinal plants. 2000 5 01 77 81 http://mjiri.iums.ac.ir/article-1-904-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 EFFECTS OF DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON BACLOFEN-INDUCED ANTINOCICEPTION IN FORM ALIN TEST MR ZARRINDAST B HASHEMI V TOLUI In this study, the influence of dopamine receptor agonists and antagonists on antinociception induced by bac10fen has been examined in the formalin test. The GABA-B agonist bac10fen induced antinociception in both phases of the formalin test in mice. The dopamine receptor agonists SKF 38393 and quinpirole also induced antinociception in both phases of the test. SKF 38393 but not quinpirole potentiated the response to bac10fen in the first phase of the test. The dopamine receptor antagonists SCH 23390 and sulpiride increased the response to baclofen in the first phase. Both drugs induced antinociception in the first phase of the fonnalin test. However, low doses of sulpiride increased the pain response in the second phase. The peripheral dopamine receptor antagonist domperidone did not alter the effect of the test by itself. Dopamine receptor mechanisms appear to interact with baclofen-induced antinociception. Baclofen dopamine agonists dopamine antagonists formalin test mice. 2000 5 01 69 75 http://mjiri.iums.ac.ir/article-1-903-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 EPINEPHRINE SUPPRESSES SECRE TION ORVLDLASSOCIATED TRIACYLGLYCEROLAND INCREASES TRIACYLGLYCEROL AND PHOSPHOL IPID CON TEN TS IN ISOL ATED RAT HEPATOCY TES M RASOULI MehdIRasoull@hotmall.Com M SHARIF M ZAHRAIE The effect of epinephrine on triacylglycerol secretion was investigated in isolated rat hepatocytes. The effect appeared at concentrations of more than 1 µM and reached a plateau at 10 µM. Epinephrine concentration for half of the maximal bioeffect (EC50) was about 1 µM. Epineplrrine at a concentration of 10 µM suppressed triacylglycerol secretion by 33% and increased its cellular content by approximately 18%. The total triacylglycerol content of the system (sum of the cell and the incubation medium) was constant at all concentrations of epinephrine. Time course experiments for triacylglycerol secretion exhibited relatively similar results on the basis of lipid analysis with or without lipid extractions. On the former basis triacylglycerol secretion versus time followed a linear relationship with a slope of 1.47 ± 0.11 µmole TG/3h/ g wet liver. Time course curves of cellular lipids revealed that cellular triacylglycerol and phospholipid contents in the presence of epinephrine were higher than the control at all time points, and the difference was constant during time. Furthermore, in the presence of glucose (20 mM) and oleate (0.25 mM), intracellular triacylglycerol content increased markedly (≥45%) whereas cellular phospholipid content remained constant. It is proposed that epinephrine exerts an inhibitory effect on VLDL secretion probably through blocking in the secretory pathway. Epinephrine Phospholipid Hepatocytes Triacylglycerol VLDL. 2000 5 01 61 68 http://mjiri.iums.ac.ir/article-1-902-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 A NEW CYTOCOLORIMETRIC ASSAY USING PHOSPHATAS E ACTIVI T Y FOR MEASURING CELLULAR FUNCTIONS A.A.N.P.M DABARE A.M.E. NOURI MRC Path R.T.D. OLIVER In this study cellular phosphatase activity, referred to as enzyme developed color (EDC) assay, was used for an in vitro assessment of cell proliferation and cytotoxicity. Optimum conditions were established and found to be 10 x103 cells / well at 37°C and 60 min incubation (for developing color). Under the same conditions a direct correlation between optical density (00) and cell number was observed. Thus, the ODs for a cell line, Ish at 100, 50, 25 and 10 X 103 cells/well were 1.0S ±0.05, 0.59 ±0.02, 0.33 ±0.02, and 0.17 ±0.01 respectively (r=0.995,p<0.001). When EDC was compared with another colorimetric assay, i.e. MTT, the results showed a direct correlation with r=0.995, p0.05), 0.19±0.01 (p>0.05), respectively. The assay was also shown to be suitable for the measurement of cell cytotoxicity and compared well with the MTT assay. These findings indicated that a simple, rapid and economical EDC assay could be used to investigate various cellular functions. The main advantage of EDC is it's suitability to use stored cells. This provides flexibility for testing samples stored over a long period in order to limit inter-experimental variations Alkaline phosphatases; testis tumor; cell proliferation 2000 5 01 53 59 http://mjiri.iums.ac.ir/article-1-901-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 RAPID EYE MOVEMENT SLEEP DEPRIVATION INDUCES ACETYLCHOLINESTERASE A CTIVITY IN THE PREOPTIC AREA OF THE RAT BRAIN MOHAMMAD HOSSEIN NOYAN ASHRAF noyan@cd.gu.ac.ir GILA BEHZADI BEHNAM JAMEIE Acetylcholinesterase (AchE) is a large glycoprotein that, aside from its known cholinolytic activity, co-exists with other transmitter systems and possesses other functions. In the present study, the effects of short-term rapid-eye-movement sleep deprivation (REM-SD) on AchE activity in the anterior hypothalamic area have been investigated. Using the flower-pot method, adult male albino rats were deprived of REM sleep for a period of72, 96, and 120 h and perfused brains were then sectioned with a vibratome and stained histochemically for AchE. In comparison to control animals, marked positive AchE activity was observed in neurons located in the preoptic area in the 120SD group only. Results of this study have shown that AchE could be involved in some unknown functions related to REM sleep physiology Sleep deprivation Acetylcholinesterase Preoptic area Rat brain. 2000 5 01 47 51 http://mjiri.iums.ac.ir/article-1-900-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 S TUDY OF CYTOMEGAL OVIRUS ANTIB ODY IN ATHEROSCLEROTIC PATIENTS IN TABRIZ S EBRAHIM-POOR S SAMADIKHAH J JAVANMARDY S MOZAFFARY H KOOSHAVAR S RASSY To evaluate the correlation of cytomegalovirus (CMV) and coronary artery disease (CAD), one-hundred patients with CAD and the same number of healthy individuals as a control group were randomly selected and studied for anti-CMV using ELISA method. Ninety percent of patients and 77 percent of the control group were anti-CMV positive and statistical analysis showed a significant correlation between these groups (p<0.05). Certain risk factors such as hypertension, hyperlipidemia, diabetes, smoking, type A personality and familial history were also studied. The distribution of these factors in the patient group were higher than those of the control group and a significant correlation was observed between these groups, but no dependency was observed between anti CMV and the above parameters in the patient group. Results of this study showed a meaningful correlation between the anti-CMV level and coronary artery disease. Atherosclerosis Anti-cytomegalovirus antibody. 2000 5 01 43 45 http://mjiri.iums.ac.ir/article-1-899-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 THE EFFECT OF ARTERIAL O2 SATURATION AND HE ART RATE ON BLOOD PRESSURE DURING HYPOXIA MH BOSKABADY S KARBANDI A ABEDINZADEH A periodic increase in blood pressure (BP) occurs during apneic episodes in patients with obstructive sleep apnea (OSA). Several factors including hypoxemia and an increase in heart rate (HR) were reported to be responsible for this increased BP. To examine the contribution of these two factors in increasing BP, 35 healthy male subjects (mean age±SD= 23.64±3.80) were studied in three experimental conditions, each condition for two minutes, including breathing room air at rest (normoxic), breathing low 02 (10%) air (hypoxic), and exercising on an ergometer while breathing room air (exercise). During the last minutes of each condition, changes in mean BP (ΔmBP), HR (ΔHR), and arterial O2 saturation (,ΔSaO2) were measured. The results showed that ΔmBP and ΔHR were significantly higher in both hypoxic and exercise conditions than normoxic condition (p<0 .00 1 for both cases). However, , ΔSaO2 was significantly lower in the hypoxic state compared to normoxic conditions. There was no significant difference in ΔHR between hypoxic and exercise groups, but both ΔmBP and , ΔSaO2 were significantly lower in hypoxic than exercise conditions (p<0.005 and p< O. OOl for ΔmBP and , ΔSaO2, respectively). There was a weak correlation between ΔmBP and ΔHR in the hypoxic condition (r=0.3, p<0.05), but the correlation between ΔmBP and ΔHR in the exercise condition was stronger (r=0.57, p< 0.001). These results indicated that although hypoxemia contributes to increased BP during hypoxia, an increase in HR is a stronger mechanism for this phenomenon. Blood pressure Heart rate O2 Saturation Hypoxia. 2000 5 01 37 41 http://mjiri.iums.ac.ir/article-1-898-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 NINE CASES OF MALIGNANCY AFTER KIDNEY TRANSPLANTATION FARAHNAZ FALLAHIAN MOHAMMAD REZA KHATAMI PARVIZ JABAL AMELI ABAS RAHIMI Renal transplantation is considered one of the best long-term therapies for chronic renal failure, but unfortunately the incidence of malignancy significantly increases in renal transplant recipients. We analyzed nine cases of malignancy in 200 renal transplant recipients occurring in a 12-year follow-up in Imam hospital of Tehran University, Tehran, Iran. According to this study, the organ most commonly affected with malignancy in our series was the skin and the mean time of neoplasm occurrence after kidney transplantation was 2.9 years. Kidney transplantation; malignancy; immunosuppression. 2000 5 01 33 36 http://mjiri.iums.ac.ir/article-1-897-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 GROWTH PATTERN OF EXCLUSIVELY AN D NONEXCLUSIVELY BR EA ST-FED INFANTS IN THE FIRST 4 MONTHS OF LIFE MINO D. FROOZANI KOBRA PERMEHZADEH BANAFSHEH GOLESTAN AHMAD REZA DOROSTY M0TLAGH Thirty-two exclusive and twenty-seven non-exclusively breast-fed infants were followed-up from birth to 4 months of age in a maternity hospital, with a rooming-in program. Face to face BF education was given to mothers in two groups after delivery and also during 4 months post-partum. Body weight (Wt ), length (L) and head circumference (HC) of the infants were measured at monthly intervals, and their feeding patterns were recorded. The Wt of exclusively breastfed infants was higher than non-exclusively breast-fed infants. The faltering of infant's growth from 3 months of age was seen in both groups. From the age of 3 months, the Wt of non-exclusively breast-fed infants was lower than the 50th percentile of the reference value (NCHS), but Land HC increments were similar in both groups. Mean Wt, Land HC of exclusively breast-fed female infants were higher compared to non-exclusive females and also higher than exclusive male and non-exclusively breast-fed male infants. In the present study, the faltering of growth of infants was seen in the first 4 months of age, in comparison to breastfed infants in the Darling study. Exclusive breast feeding Anthropometry Weight Length Head circumference. 2000 5 01 27 32 http://mjiri.iums.ac.ir/article-1-896-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER MOHAMMAD REZA SABRI MOHAMMAD RAHIM KADIVAR MOHAMMAD BORZOUEE The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of once every 4 weeks injection of BPG. Our study was designed to determine serum penicillin levels (SPL) during the 4 weeks after an intramuscular injection of 1,200,000 units of BPG, in order to find the appropriate interval between BPG injections and also to assess the effects of weight and sex on this level. We included 42 RF patients (mean±SD=14.8±11.9 years) in our study. SPL was determined by disk agar diffusion method. In this study the minimum accepted SPL to be effective against group A β-hemolytic streptococci was 0.02 µg/mL. In 46% of the patients the mean SPL decreased to <0.02 µg/mL at the end of the third week (mean ±SD=2.35 ± 1.3 weeks). The mean SPLs were significantly higher in patients who weighed <45 kg (mean±SD=38.6±4.3 kg) in comparison with those who weighed 2:45 kg (mean±SD=54.25±4.87 kg), with a p value <0.0001. There was no significant differences in mean SPL between boys and girls (p =0.145). Although in this study the mean SPL was <0.02 µg/mL in 46% of patients at the end of the third week, we could not recommend every 3 weeks injections of BPG in all patients, except in high risk patients and situations as recommended by the WHO and also in those patients who weighed 2:45 kg. Rheumatic Fever Secondary Benzathine Penicillin Prophylaxis Children Serum Penicillin Level. 2000 5 01 23 26 http://mjiri.iums.ac.ir/article-1-895-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 UNILATERAL POLYCYSTIC OVARY SYNDROME SHAYESTEH JAHANFAR JOHN A. EDEN Two-hundred and seventeen subjects underwent transvaginal ultrasound -17 (8%) had unilateral polycystic ovary (PCO). Twelve percent of subjects with unilateral scan-pea had oligomenorrhea, 24% were amenorrheic, 23% were hirsute and 29% had acne. Biochemical parameters were compared between subjects with unilateral scan- PCO and those with bilateral scan- PCO (n=200) as well as a group of scan-normal women (n=29). No significant difference was found between subjects with bilateral and unilateral scan- PCO suggesting that these 2 groups are biochemically similar. The existence of unilateral scan- PCO suggests that peas may be a primary ovarian disorder. Polycystic ovary syndrome Unilateral polycystic ovary Primary ovarian disorder. 2000 5 01 19 22 http://mjiri.iums.ac.ir/article-1-894-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 GRADED P NEUMATIC DILATATION WI THOUT FLUOROSCOPY IN THE T REATMENT OF ESOPHAGEAL ACHALASIA J MIKAELI R MALEKZADEH M KHATIBIAN R ANSARI H VAHEDI H SOLIMANI Between 1993-1996 seventy-three consecutive patients (33 M, 40 F, mean age 35.4) with newly diagnosed achalasia underwent one or more pneumatic dilatations with the Rigiflex balloon using a protocol of graded dilatation with a fixed inflation pressure of 10 psi and constant duration of 30 seconds for all patients without using fluoroscopy. Using Vantrappen's classification for assessment of response, excellent or good results were considered as cure and fair or poor results as failure. Duration of symptoms and the amount of weight loss before dilatation averaged 5.2 years and 10 kg, respectively. In 62 patients one, in 5 patients two, and in 4 patients three dilatations were performed. Dilatation failed in one patient because of previous surgery and was followed by perforation in one patient (1.4%) and bleeding in another patient (1.4%). Follow up period averaged 20 months (range 6-38 months) with a cure rate of 90% (57 excellent, 9 good) and failure rate of 6.8% (3 fair, 2 poor). We conclude that graded pneumatic dilatation without fluoroscopy is a safe and very effective treatment for achalasia with 90% of patients having a sustained response lasting at least for an average of 20 months. Achalasia pneumatic dilatation fluoroscopy esophageal perforation. 2000 5 01 15 18 http://mjiri.iums.ac.ir/article-1-893-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 THE INCI DENC E OF PROS TATIC INTRAEPI THELIAL NEOPLASIA IN PROSTATIC HYPERPLASIA AND PROS TATIC C ARCINOMA S TORABI-NEZHAD S MAFTOUN Prostatic intra-epithelial neoplasia (PIN) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. In this study, we applied the PIN grading system on one-hundred cases of prostatic carcinoma and one-hundred cases of benign prostatic hyperplasia, then compared the results. 74% of prostatic carcinoma and 51 % of prostatic hyperplasia cases showed PIN foci. Most of the prostatic carcinomas (61 %) showed foci of high-grade PIN including grade II (46%) and grade III (15%). In benign prostatic hyperplasia cases, only PIN grade I (26%) and grade II (25%) were seen. It is concluded that PIN and invasive adenocarcinoma of prostate are closely associated and the likelihood for coexistence is higher in patients with high grade PIN and especially if other factors such as prostate specific antigen and positive findings on sonography are also considered. Prostate Prostatic intra-epithelial neoplasia Prostatic carcinoma Benign prostatic hyperplasia. 2000 5 01 9 13 http://mjiri.iums.ac.ir/article-1-892-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 PRIMARY MALIGNANT TUMORS OF THE SMALL INTESTINE: ANALYSIS OF 156 IRANIAN PATIENTS H SAADATNIA S SERESHKI T GHIASI MOGHADAM 156 Iranian patients with primary malignant tumors of the small intestine were reviewed. Malignant lymphoma was the most common tumor type, comprising 128 patients (82%), followed by adenocarcinoma (22 patients, 14.1 %), leiomyosarcoma (4 patients, 2.56%) and carcinoid tumor (2 patients, 1.28%). Lymphomas and adenocarcinomas were primarily located in the duodenum or jejunum, whereas leiomyosarcomas were more cornmon in the ileum. Abdominal pain (73%), weight loss (68%), diarrhea (41% ), and nausea or vomiting (35%) were the most common symptoms with these tumors. Among the lymphoma group 95 patients (74.2%) had non-IPSID (immunoproliferative small intestinal disease) lymphoma and 33 patients (25.8%) had IPSID related lymphoma. In contrast to the western world and far east countries in which malignant small intestinal tumors are a disease of middle and old age groups and adenocarcinoma is the most common tumor type, in our area, similar to some other middle east and north African countries, lymphomas are much more frequent. Although Iran is endemic for IPSID related lymphoma, the majority of these tumors are non-IPSID lymphomas and appear in a very young age group (mean age 27 y). Neoplasm adenocarcinoma malignant lymphoma leiomyosarcoma. 2000 5 01 5 8 http://mjiri.iums.ac.ir/article-1-891-en.pdf
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Medical Journal of The Islamic Republic of Iran (MJIRI) Med J Islam Repub Iran 1016-1430 2251-6840 10.18869/mjiri 2000 14 1 VARICOCELE SIZE AND SEMEN QUALITY A A. SHAHRAZAD SF In this study we have described our varicocele cases in terms of associated symptoms/signs. In addition, we have tested the correlation between semen parameters and varicocele grades and compared the relative frequencies of associated symptoms/signs in different varicocele grades. 1 19 referred cases of varicocele were categorized based on clinical criteria into 3 grades by one examiner. The relative frequencies of associated symptoms/signs of the grades were compared. 52 of the cases whose semen analyses were performed at the same laboratory were included for comparison of semen parameters. Most of the cases were single conscripts. Age range was 1 8 to 38 years and the mean age was 23 years. Pain was the most common associated finding in our mostly single physically active cases. Of all the 1 19 cases, 9 were grade 1 , 63 grade 2, and 47 grade 3. Mean sperm concentration was 60.3 million per cubic centimeter. No significant difference was found in the relative frequencies of associated symptoms/signs among different grades. Difference in semen parameters among grades was negligible and not significant at 0. 1 (0.05 as well). Pain could be the most common associated finding in young single physically active varicocele cases. It seems that varicocele grade bears no significance over the relative frequencies of associated symptoms/signs. Our data is against any clinically and/or statistically significant relationship between varicocele size and semen parameters. Varicocele Semen Grade. 2000 5 01 1 4 http://mjiri.iums.ac.ir/article-1-890-en.pdf