Volume 11, Issue 2 (8-1997)                   Med J Islam Repub Iran 1997 | Back to browse issues page

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COMPARISON OF THE ACUTE BRONCHO DILATING EFFECTS OF INHALED IPRATROPIUM BROMIDE AND SALBUTAMOL IN PATIENTS WI TH CHRONIC OBSTRUCTIVE PULMONARY DISE ASE
S MOHAMEDI , F ROSHANZAMIR , A MAHDAVI , MH POURGHOLAMI
From the Tehran University of Medical Sciences, Tehran, and the Dept. of Pharmacology, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Abstract:   (5544 Views)
Forty-five patients with chronic obstructive pulmonary disease were studied to compare the acute effects of ipratropium bromide (60 µg), salbutamol (300 µg) and placebo (3 puffs) on the forced expiratory volume in 1 sec (FEV 1) and forced vital capacity (PVC). Ipratropium bromide produced a significantly greater improvement than salbutamol in both FEV1 and FVC at 15,60 and 180 minutes after drug administration. It may therefore be concluded that in patients with chronic obstructive pulmonary disease, ipratropium bromide has greater potency and a longer duration of action than salbutamoL
Keywords: Ipratropium bromide, salbutamol, anticholinergic, chronic obstructive pulmonary disease.
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Type of Study: Original Research | Subject: Pharmacology
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