Volume 19, Issue 3 (11-2005)
Med J Islam Repub Iran 2005 |
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Department of Bacteriology and the 2Department of Medical Physics, Tarbiat Modares , kashefn@modares.ac.ir
Abstract: (5318 Views)
Objective: The effect of ceftazidime on Pseudomonas aeruginosa, with or without
application of 1 MHz therapeutic ultrasound, was studied.
Method: An aqueous suspension of microorganisms in a sterile, sealed plate was
placed in an ultrasonic tank operating at 1 MHz. Different power outputs were used.
After desired time of exposure to the ultrasound, each sample was plated separately
and after incubation, the number of colonies was counted.
Results: Results showed that ultrasound in combination with sMICs of ceftazidime
was much more lethal to this bacterium than either of the treatments alone. The mechanism
by which ultrasound enhances antibiotic action is due to the induction of uptake of
antibiotic by perturbing or stressing the membrane.
Conclusion: This application of ultrasound may be useful for expanding the number
of drugs available for treating localized infections by rendering bacteria susceptible
to normally ineffective antibiotics.
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