Volume 36, Issue 1 (1-2022)                   Med J Islam Repub Iran 2022 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bagheri M, Ghaneialvar H, Oshnokhah M, Salari S. GFAP and Neuron Specific Enolase (NSE) in the Serum of Suicide Attempters. Med J Islam Repub Iran 2022; 36 (1) :771-775
URL: http://mjiri.iums.ac.ir/article-1-7981-en.html
Department of Physiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran , sajjad.salari@medilam.ac.ir
Abstract:   (695 Views)
Background: To determine whether neuronal damage and/or neuroinflammation exist in the brain of suicide attempters and to find a novel biological biomarker to help distinguishing high risk individuals with suicide behavior, we aimed to measure glial fibrillary acidic protein (GFAP), neuron specific enolase (NSE), and nerve growth factor (NGF) in suicide attempters.
   Methods: In the present case-control study, the serum level of NSE, GFAP, and NGF were measured quantitatively in 43 suicide attempters and 43 healthy control participants aged 18 to 35 years. Data were analyzed using the nonpaired t test followed by the Mann-Whitney posttest.
   Results: The mean serum level of NSE and GFAP were significantly higher in suicide attempters compared with healthy control individuals (p = 0.003, p = 0.001, respectively), while no significant difference was detected in NGF serum level between the 2 groups.
   Conclusion: Our findings of increased level of NSE along with the significant increase in GFAP would propose the presence of low grade neuroinflammation in the brain of these participants. NSE/GFAP might be good markers that is easily accessible and can be considered as prognostic markers in high-risk suicide attempters. 
Full-Text [PDF 425 kb]   (209 Downloads)    

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.