Volume 14, Issue 4 (2-2001)
Med J Islam Repub Iran 2001 |
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From the Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran. , hsadraei@yahoo.com
Abstract: (5159 Views)
Teucrium polium L. (Lamiaceae) is used in the traditional medicine of Iran
for the treatment of disorders of the gastrointestinal tract. The essential oil from
the aerial parts of T polium was assessed for antispasmodic activity and compared
with the effect of atropine and dicyclomine. Acetylcholine and KC I were
used for induction of contraction on rat isolated ileum. Teucrium polium essential
oil (TPEO) at concentrations of 8.6 to 34.4 µg/mL attenuated the maximum inducible
response to acetylcholine concentration-response curve. It also inhibited
the response to 80 mM KC I in a concentration dependent manner (pD2= 1.2±0 .13).
Dicyclomine (3.46 & 34.6 ng/mL) also reduced the response to acetylcholine on
rat isolated ileum and inhibited KC1-induced contractions while atropine only
inhibited the response to acetylcholine. This study shows that TPEO is a relaxant
of rat isolated ileum and may have some clinical benefits for gastrointestinal disorders
such as colic.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Pharmacology
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