Volume 14, Issue 3 (11-2000)
Med J Islam Repub Iran 2000 |
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the School of Medicine, Department of Microbiology, Urumieh University of Medical Sciences
Abstract: (4538 Views)
In this study, twenty-five strains of Mycobacterium tuberculosis resistant to
isoniazid (INH) were isolated from patients with tuberculosis (TB). Nine strains
(36%) were found to be virulent in guinea-pigs [root index virulence (RIV» 1 ].
The remaining sixteen strains (64%) were non-virulent (RIV <1). Of the nine strains
resistant to INH as well as virulent to guinea-pigs, eight of them were found to be
catalase positive and only one strain was catalase negative, whereas the remaining
sixteen INH resistant strains were catalase negative. A strong association was
observed between INH resistance and catalase positivity and virulence (p<0.0001
chi-square test). This study supports the hypothesis that catalase has an important
role in the virulence of INH-resistant strains of M tuberculosis.
Type of Study: Original Research |
Subject:
Microbiology and Anatomy
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