Volume 38, Issue 1 (1-2024)                   Med J Islam Repub Iran 2024 | Back to browse issues page

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Iranirad L, Sadeghi M S, Hejazi S F. Prospective Randomized Trial of Na/K Citrate for the Prevention of Contrast-Induced Nephropathy in High-risk Patients. Med J Islam Repub Iran 2024; 38 (1) :172-177
URL: http://mjiri.iums.ac.ir/article-1-8955-en.html
Department of Cardiology, Qom University of Medical Sciences, Qom, Iran , dr.saleh.sadeghi88@gmail.com
Abstract:   (390 Views)
Background: Contrast-induced nephropathy (CIN) or contrast-induced acute kidney injury (CI-AKI) refers to an acute kidney injury (AKI) occurring after exposure to contrast media, commonly used in diagnostic procedures or therapeutic angiographic interventions. Recently, Na/K citrate, used for urine alkalinization, has been assessed for preventing CIN. This experiment evaluated Na/K citrate’s efficacy in preventing CIN in high-risk patients undergoing cardiac catheterization.
   Methods: A prospective randomized clinical trial involved 400 patients with moderate- to high-risk factors for CIN undergoing elective percutaneous coronary intervention (PCI). They were randomly assigned to either the control or Na/K citrate groups. The Na/K citrate group (n = 200) received a 5 g Na/K citrate solution diluted in 200 mL water 2 hours before and 4 hours after the first administration, along with intravenous hydration for 2 hours before and 6 hours after the procedure. In contrast, the control group (n = 200) received only intravenous hydration. Serum creatinine (SCr) levels were measured before contrast exposure and 48 hours afterward. CIN was defined as a 25% increase in serum creatinine (SCr) or > 0.5 mg/dL 48 hours after contrast administration. The significance level was set at P ˂ 0.05.
   Results: CIN was observed in 33 patients (16.5%) in the control group and 6 patients (3%) in the Na/K citrate group. The incidence of CIN was found to have a significant difference between the 2 groups 48 hours after receiving the radiocontrast agent (P < 0.001).
   Conclusion: Our results show that Na/K citrate is helpful and substantially reduces the incidence of CIN.
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Type of Study: Original Research | Subject: Cardiology

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