Volume 13, Issue 3 (11-1999)
Med J Islam Repub Iran 1999 |
Back to browse issues page
From the Department of Immunology, Faculty of Medicine, Baghiatollah University of Medical Sciences,
Abstract: (4879 Views)
Recent studies have established that sex hormones directly or indirectly affect
T and B cells and macrophages by manipulating the production of cytokines. In this
study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide
(NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα)
was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were
neutralized by hamster anti-mouse IL-1β, rat anti-mouse IL-6 or goat anti-mouse
TNF-α monoclonal antibody, respectively. Blocking of IL-1β and TNF-α resulted in decrease in NO release. Neutralizing of IL-6 caused an increase in nitric
oxide (NO) production. With regard to these findings, it can be concluded that 5αDHT
may enhance NO production in peritoneal macrophages via modulation of
cytokine secretion.
Type of Study: Original Research: Basic Science in Medicine |
Subject:
Immunology
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |