Volume 13, Issue 1 (5-1999)
Med J Islam Repub Iran 1999 |
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From the Departments of Physiology Tehran University of Medical Sciences. Tehran. I.R. lran.
Abstract: (4785 Views)
The discovery of the antifertility activity of gossypol led scientists and researchers to the development of compounds with antifertility activity that can be used as male contraceptives. These studies resulted in discovery of the antifertility activity of several classes of compounds which have been reported in the literature. This article deals with the synthesis of four new analogues of pyrimethamine, the derivatives of 2, 4-diamino-5 (3,4-dichlorophenyl)-6-alkyloxymethyl pyrimidine (methyl ethyl, n-propyl, iso-propyl), and the results of experimental antifertility evaluation of these compounds on male rats, which revealed a significant decrease in motility, viability, ESR and DSP indices in treated animals
Keywords: 2, 4-Diaminopyrimidines; Male contraception; Male reproduction; Spermatogenesis; Fertility
Type of Study: Original Research |
Subject:
Physiology
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