@ARTICLE{Honardoost, author = {Aghili, Rokhsareh and Honardoost, Maryam and Khamseh, Mohammad E and }, title = {COVID-19: Case fatality and ACE2 inhibitors treatment concerns in patients with comorbidities}, volume = {34}, number = {1}, abstract ={The Corona Virus Disease 2019 (COVID-19) outbreak is becoming pandemic with the highest mortality in patients with associated comorbidities. These RNA viruses containing 4 structural proteins usually use spike protein to enter the host cell. Angiotensin-converting enzyme 2 (ACE2) acts as a host receptor for the virus. Therefore, medications acting on renin-angiotensin-aldosterone system can lead to serious complications, especially in patients with diabetes and hypertension. To avoid this, other potential treatment modalities should be used in COVID-19 patients with associated comorbidities. }, URL = {http://mjiri.iums.ac.ir/article-1-6799-en.html}, eprint = {http://mjiri.iums.ac.ir/article-1-6799-en.pdf}, journal = {Medical Journal of the Islamic Republic Of Iran}, doi = {10.47176/mjiri.34.147}, year = {2020} }