en Pharmacology Pharmacology Original Research Original Research In this study, the effect of lovastatin and fluvastatin was compared with placebo in patients with high levels of total cholesterol and low density lipoprotein cholesterol (LDL-C) on the plasma lipid profile. In a prospective single blind clinical trial with convenient sampling, 120 hypercholesterolemic men and women with Tcholesterol ≥220 mg/dL, LDL-C ≥ 160 mg/dL, and triglyceride ≤ 350 mg/dL were selected and divided into 3 groups randomly. The fust group took lovastatin, 20 mg daily, the second group fluvastatin, 40 mg daily, and the third group took a placebo, all for 12 weeks. Compared with placebo, drug therapy of hypercholesterolemia with either lovastatin or fluvastatin decreased total cholesterol and LDL-C levels significantly but had no effect on high density lipoprotein and triglyceride values. Decrease of total cholesterol and LD L-C levels by both drugs are similar after the first 6 weeks but lovastatin was more effective after the second 6 week period. Fluvastatin, Lovastatin, Hypercholesterolemia 229 233 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-451&slc_lang=en&sid=1 S MORADMAND 20031947532846004768 20031947532846004768 Yes From the Department of Pharmacy and Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. MR NIAKAN 20031947532846004769 20031947532846004769 No F FOULADKOU 20031947532846004770 20031947532846004770 No A SHAFIEE 20031947532846004771 20031947532846004771 No