Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1377
5
1
gregorian
1998
8
1
12
2
online
1
fulltext
en
ATTENUATION OF PARAQUAT TOXICITY IN MICE
Pharmacology
Pharmacology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Paraquat (PQ) is a widely used herbicide. However, a large number of cases
of accidental or suicidal poisoning from PQ has been reported. Membrane
damage induced by lipid peroxidation, inactivation of protein or damage to
DNA by radical formation have been suggested as toxicity mechanisms of PQ.
In the present work, the effects of atropine, propranolol, procainamide and
dipyridamole on PQ-induced intoxication have been studied.
Oroups of male albino mice were used under standard conditions. All the
drugs were injected intraperitoneally in different doses. The results indicated
that administration of PQ (40 mg/kg, i.p.) increased the death rate of animals
(77%) during 3 days, whereas a dose of 20 mg/kg of PQ only decreased the lung
tissue total protein and glutathione (OS H) content. This poison also produced
serious histopathologic changes in lung tissue. Administration of propranolol
( 10 and 20 mg/kg), procainamide (20 and 40 mg/kg), dipyridamole (30 and 60
Mg/kg) and atropine (5 and 10 mg/kg) decreased the PQ (40 mg/kg)-induced
mortality rate in the pre- or post-treatment regimens. These drugs were also
effective in reversing the PQ-induced alteration in the lung tissue protein and
OSH content, however the pathological findings attenuated in the treated
animals. Although the exact mechanism of these drugs against paraquat-toxicity
in mice is still unknown, it appears that some of the drugs used may be effective
in reversing PQ-induced poisoning in mice and possibly their effects are related
to the inhibition of membrane lipid peroxidation via different mechanisms.
Paraquat, atropine, propranolol, procainamide, dipyridamole, mice
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-472&slc_lang=en&sid=1
M
REZAYAT
20031947532846004853
20031947532846004853
Yes
From the Dept. of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
M
OMIDI
20031947532846004854
20031947532846004854
No
M
RAMAZANI
20031947532846004855
20031947532846004855
No
M
KARAMI
20031947532846004856
20031947532846004856
No
H
SABERI
20031947532846004857
20031947532846004857
No
A
BAKHTIARIAN
20031947532846004858
20031947532846004858
No