en Cardiovascular Surgery Cardiovascular Surgery Original Research Original Research The purpose of this investigation was to assess the effect of captopril on both systemic (P.a) and pulmonary arterial pressures (PPA) in patients with high-altitude pulmonary hypertension (HAPH). Seventeen patients (mean age 44±6.8 years) with HAPH and mild to moderate systemic arterial hypertension were included in the study. All patients underwent right heart catheterization with measurements of systolic PPA (PPA,syst) , mean PPA, (P¯PA) and diastolic PPA (PPA,diast)• After 4 weeks placebo phase patients with a PPA, sst> 25 mmHg, P¯PA > 15 mm Hg and systemic diastolic blood pressure (Pa,diast) >100 mmHg were given captopril (50-75 mg at 8 am) for a period of 12 weeks. The statistical evaluation of the results was made using Student's t-test. It was found that captopril significantly decreases PPA and Pa. Captopril, pulmonary hypertension, systemic hypertension, high-altitude pulmonary hypertension. 179 181 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-423&slc_lang=en&sid=1 TALANTBEK A BATYRALIEV 20031947532846005308 20031947532846005308 Yes From the Department of Cardiology, Balcali Hospital, Cukurova University, Adana, Turkey. KAIRGELDY S. AYKlMBAEV 20031947532846005309 20031947532846005309 No GULMIRA Z. KUDEYBERDIEVA 20031947532846005310 20031947532846005310 No FERIT AKGUL 20031947532846005311 20031947532846005311 No GYLDYZ K. SODANBEKOVA 20031947532846005312 20031947532846005312 No