Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1375
8
1
gregorian
1996
11
1
10
3
online
1
fulltext
en
ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS
Immunology
Immunology
Original Research
Original Research
Human brucellosis is a major health problem in developing countries. A
number of patients with human brucellosis do not recover from the acute stage of
the disease and pass into the chronic form. Since the pathophysiology of this
change is not well understood, we studied the T-cell subsets during the acute,
subacute and chronic forms of human brucellosis. In this study we found
alterations in T-Iymphocyte subsets and in the CD4/CD8 ratio in subacute and
chronic brucellosis while no significant change was found in T-cell subsets in
acute brucellosis. We believe that this alteration of T-cell subsets is important in
the pathophysiology of brucellosis, but it is not clear whether brucella cause this
change or a primary immunodysfunction in patients with a disturbance in T-cell
subset regulation prevents recovery from acute brucellosis and leads to the
development of chronic brucellosis.
Brucellosis, CD4, CD8, T-Iymphocyte, Alkaline phosphatase anti-alkaline phosphatase (APAAP) method
191
194
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-425&slc_lang=en&sid=1
AA
POURFATHOLLAH
20031947532846005318
20031947532846005318
Yes
From the Dept. of Immunology, School of Medical Sciences, Tarbiat Modarress University, Tehran
MB
ESLAMI
20031947532846005319
20031947532846005319
No
the Departments of Pathobiology Tehran University of Medical Sciences,
AR
YALDA
20031947532846005320
20031947532846005320
No
Infectious Diseases, Tehran University of Medical Sciences,
AF
SARRAF NEJAT
20031947532846005321
20031947532846005321
No
the Departments of Pathobiology Tehran University of Medical Sciences,