Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1375
5
1
gregorian
1996
8
1
10
2
online
1
fulltext
en
THE EFFECTS OF DEPRESSION ON ENDOICRINE AND IMMUNE SYSTEMS
General
General
Original Research
Original Research
To study the effect of depression on the endocrine and immune systems, 557
male freshman and sophomore medical students (20-30 years old) were given
Beck's Depression Inventory. Students with marks 5 or above were selected as the
control (n=26) and those with marks of 20 or higher were chosen as the test group
(n=27). All of the students were subjected to the following tests: CBC, differential,
total cholesterol (TC), triglycerides (TG), HDL-c, VLDL-c, fibrinogen (Fibr),
cortisol (Cort), prolactin (PRL), testosterone(Test), triiodothyronine (T3), thyroxine
(T4), total serum immunoglobulins (Ig), IgA, IgG, IgM, creatine kinase (CK),
and C3 and C4 components of the complement system.
Results indicated statistically significant increases of the following parameters
in the test group as compared with the controls: TC (P < 0.05), LDL-c (P <
0.05), CK (P < 0.025), Fibr (P < 0.0 1), Test (P < 0.05), Cort (P < 0.025), IgG (P
< 0.025) and Ig (P < 0.025). The results were in accordance with the anticipated
hormonal and cell-mediated immunity alterations caused by depression, which
affected both cytokines and endorphin levels.
In spite of the limited number of subjects used in this study and lack of the
dexamethasone suppression test (DST), the overall approach of this study is
encouraging nevertheless, further studies using a 1zrger sample are required.
Depression, behavioral diseases, affectional abnormalities and schizophrenia
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-443&slc_lang=en&sid=1
MH
GHAHRAMANI
20031947532846005382
20031947532846005382
Yes
From the Schools of Paramedical Sciences , Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
M
NAZARI
20031947532846005383
20031947532846005383
No
From the Schools of Paramedical Sciences , Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
SZ
TABEI
20031947532846005384
20031947532846005384
No
From the Schools of Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
J
AHMADI
20031947532846005385
20031947532846005385
No
From the Schools of Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
SN
RAFATI
20031947532846005386
20031947532846005386
No
From the Schools of Paramedical Sciences , Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
MA
GHALAMBOR
20031947532846005387
20031947532846005387
No
School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.