en Pharmacology Pharmacology Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate was used in the other. The effects of both prepared formulations were investigated in patients suffering from anorectal diseases, using relevant placebos for comparison. The results indicated that the prepared drugs were significantly effective in the treatment of anorectal diseases. Formulations containing benzocaine proved to be more effective in patients suffering from hemorrhoids, while formulations containing belladonna dry extract and ephedrine sulfate were more effective in anal fissure and proctitis. Anti-Anorectal Disease Plants; Calendula officinalis; Plantago major; Vinca major. 73 77 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-467&slc_lang=en&sid=1 SULEIMAN AFSHARYPOUR 20031947532846005470 20031947532846005470 Yes From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan KlANDOKHT SHAFII 20031947532846005471 20031947532846005471 No From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan MOHAMMAD ESMAIL AKBARY 20031947532846005472 20031947532846005472 No the School of Medicine, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran MOHAMMAD REZA ZARGARZADEH 20031947532846005473 20031947532846005473 No From the Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan