Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1367
11
1
gregorian
1989
2
1
2
4
online
1
fulltext
en
EFFECTS OF DIFFERENT MEDIATORS ON FIBROBLAST PROLIFERATION
Immunology
Immunology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
In this study, we have investigated the proliferative response of human
dermal fibroblasts isolated from normal and psoriatic individuals to different
cytokines. We found that IL-1, TNF (α) and EGF are stimulatory whereas
IFN « and 1 both showed inhibitory activity on fibroblast proliferation.
IL-6 a more recently described cytokine, showed no detectable effects on cell
proliferation. Investigating the combined effects of these mediators on
fibroblasts, we found that while EG F has additive effects on IL-1 orTNF (α)
activated cells, both IFNs showed suppressive activity on the cell proliferation.
There was no statistical difference in proliferative response of fibroblasts
isolated from normal and psoriatic individuals. The significance of these
findings is discussed,
297
304
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-483&slc_lang=en&sid=1
AME
NOURI
20031947532846005532
20031947532846005532
Yes
From the Department of Immunology and Experimental Dermatology, The London Hopital, London EI 2A D
IM
LEIGH
20031947532846005533
20031947532846005533
No
J
MANGERA
20031947532846005534
20031947532846005534
No
A
SHAMSA
20031947532846005535
20031947532846005535
No
the 'Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran
H
FESTENSTEIN
20031947532846005536
20031947532846005536
No