Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1389
2
1
gregorian
2010
5
1
24
1
online
1
fulltext
en
Association study between schizophrenia and the DISC1 gene polymorphism
Human Genetics
Human Genetics
Original Research
Original Research
<p> <strong> Abstract </strong><strong></strong></p><p> <strong> Background: </strong>The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome </p><p> position 1q42, was initially identified at the breakpoint of a balanced translocation, </p><p> t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large </p><p> Scottish family. </p><p> <strong> Methods: </strong>Our samples included 200 unrelated patients diagnosed with Schizophrenia </p><p> on the basis of DSM-IV criteria and 200 normal controls, which were gathered </p><p> from Iran. The allele and genotype frequencies of the polymorphism were determined </p><p> using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism </p><p> (PCR-RFLP) and the data were analyzed by Logistic Regression test. </p><p> <strong> Results: </strong>In this study we genotyped the rs821616 polymorphism (Serin704Cystein) </p><p> located within exon 11 of the DISC1 gene. The samples were matched on the basis </p><p> of sex and ethnicity. We used the case control study to determine the possible association between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis of data in the samples, revealed no association between the rs821616 polymorphism and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072). </p><p> <strong> Conclusion: </strong>In this study we did not find any association between the rs821616 </p><p> SNPand schizophrenia. </p><p> </p>
association study, schizophrenia, DISC1 gene, rs821616, single nucleotide,polymorphism.
29
34
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-97&slc_lang=en&sid=1
Ali Mohammad
Foroughmand
20031947532846001923
20031947532846001923
No
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran
Maryam
Haidari
20031947532846001924
20031947532846001924
No
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
Hamid
Galehdari
galehdari@scu.ac.ir
20031947532846001925
20031947532846001925
Yes
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz-Iran
Atefeh
Pooryasin
20031947532846001926
20031947532846001926
No
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
Seyed Reza
Kazeminejad
20031947532846001927
20031947532846001927
No
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.
Shiva
Hosseini
20031947532846001928
20031947532846001928
No
Dept of genetics, College of Sciences, Shahid Chamran University, Ahvaz, Iran
Nahid
Khajeh-Mogehi
20031947532846001929
20031947532846001929
No
Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.