en Human Genetics Human Genetics Original Research Original Research <p> <strong> Abstract </strong><strong></strong></p><p> <strong> Background: </strong>The disrupted-in-schizophrenia 1 (DISC1) gene, on the chromosome </p><p>  position 1q42, was initially identified at the breakpoint of a balanced translocation, </p><p>  t(1,11)(q42.1q14.3), which segregated with major mental disorders in a large </p><p>  Scottish family. </p><p> <strong> Methods: </strong>Our samples included 200 unrelated patients diagnosed with Schizophrenia </p><p>  on the basis of DSM-IV criteria and 200 normal controls, which were gathered </p><p>  from Iran. The allele and genotype frequencies of the polymorphism were determined </p><p>  using Polymerase Chain Reaction-Restricted Fragment Length Polymorphism </p><p>  (PCR-RFLP) and the data were analyzed by Logistic Regression test. </p><p> <strong> Results: </strong>In this study we genotyped the rs821616 polymorphism (Serin704Cystein) </p><p>  located within exon 11 of the DISC1 gene. The samples were matched on the basis </p><p>  of sex and ethnicity. We used the case control study to determine the possible association between the ser704cys (rs821616) polymorphism and Schizophrenia. Analysis of data in the samples, revealed no association between the rs821616 polymorphism and Schizophrenia (OR= 0.697, 95% CI= 0.47-1.033, P=0.072). </p><p> <strong> Conclusion: </strong>In this study we did not find any association between the rs821616 </p><p>  SNPand schizophrenia. </p><p>  </p> association study, schizophrenia, DISC1 gene, rs821616, single nucleotide,polymorphism. 29 34 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-97&slc_lang=en&sid=1 Ali Mohammad Foroughmand 20031947532846001923 20031947532846001923 No Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran Maryam Haidari 20031947532846001924 20031947532846001924 No Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran. Hamid Galehdari galehdari@scu.ac.ir 20031947532846001925 20031947532846001925 Yes Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz-Iran Atefeh Pooryasin 20031947532846001926 20031947532846001926 No Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran. Seyed Reza Kazeminejad 20031947532846001927 20031947532846001927 No Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran. Shiva Hosseini 20031947532846001928 20031947532846001928 No Dept of genetics, College of Sciences, Shahid Chamran University, Ahvaz, Iran Nahid Khajeh-Mogehi 20031947532846001929 20031947532846001929 No Dept of Genetics, College of Sciences, Shahid Chamran University, Ahvaz,Iran.