en Pharmacology Pharmacology Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine The study of toxicities which are caused by free radical inducing chemicals (e.g., carbon tetrachloride), helps to determine the mode of action of those important drugs which act by inhibiting free radicals. Evaluation of toxicities induced by carbon tetrachloride and phenobarbitone administration was carried out in seventy healthy male rabbits. Each animal received CCI4 0.25-0.5 mL/kg body weight, intraperitoneally, twice weekly for eleven doses. During this period, the only water which was provided for drinking to these animals contained 0.25 g/L pentobarbitone. Examination of these animals revealed that carbon tetrachloride produced severe liver and kidney injuries which could be assessed by physical parameters, liver and kidney function tests, and microscopic .examinations of the vital organs of these aninlals. 131 136 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-543&slc_lang=en&sid=1 IFFAT ZEHRA 20031947532846005923 20031947532846005923 Yes From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi MOHAMMAD TARIQ AFTAB 20031947532846005924 20031947532846005924 No From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi ASIF BIN REHMAN 20031947532846005925 20031947532846005925 No From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi QAMAR JAMAL 20031947532846005926 20031947532846005926 No the Department of Pathology, Institute of Basic Medical Sciences, Jinnah Post Graduate Medical Center, Karachi, Pakistan. SHAHID RASHID 20031947532846005927 20031947532846005927 No From the Department of Pharmacology, Faculty of Pharmacy, University of Karachi