Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1373
5
1
gregorian
1994
8
1
8
2
online
1
fulltext
en
CD38 MOLECULE-A MULTILINEAGE GLYCOPROTEIN AND ITS UNIQUE EXPRESSION ON PLASMA CELLS
Microbiology and Anatomy
Microbiology and Anatomy
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
A hybridoma clone designated 6G5 has been selected by fusion of mouse
myeloma cell line Ag. 8653 with spleen cells from mice immunized with human
peripheral blood mononuclear cells (PBMC). The antibody produced by this clone
was found to be strongly reactive with four human B-cell lines in the conventional
immunological assays. Despite the fact that expression of most B cell-associated
markers are lost upon differentiation of B-cells to plasma cells, the expression of the
6G5 reactive molecule remains unchanged. The lack of reactivities of this MAb for
mature T-cells, and monocytic cell lines indicates that this MAb recognizes a B cell associated
marker. Western blot analysis indicated that the 6G5 MAb detected a
single band with molecular weight of 41 KDa from cell lysates of two human B-cell
lines, DAUDI and NALM6. Comparison of data obtained for 6G5 MAb with those
of the MAb known as OKTIO indicated that both MAbs may have reacted with the
same molecule.
109
113
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-591&slc_lang=en&sid=1
ABBAS
A. GHADERI
20031947532846006072
20031947532846006072
Yes
From the Dep. Of Microbiology and Immunology, Medical School, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran.
ZAHRA
AMIRGHOFRAN
20031947532846006073
20031947532846006073
No