Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1372
8
1
gregorian
1993
11
1
7
3
online
1
fulltext
en
POSSIBLE INVOLVEMENT OF GABAA RECEPTOR SITES IN CATALEPSY
Physiology
Physiology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
The present work was performed to show the possible interaction of GAB A, and
GABAB receptors in catalepsy. The following results were obtained:
1- Muscimol (MUS), a GABAA agonist, induced catalepsy. This effect was
dose-dependent. Baclofen (BAC), a GABAB agonist, had no effect in this respect.
2- Catalepsy induced by muscimol was potentiated by pretreatment of animals
with bicuculline (BIC), a GABAA antagonist, while pretreatment of animals with
picrotoxin (PIC), another GABAA antagonist, did not change the response.
3- The cataleptogenic effect of a-flupenthixol (a-FPT), a neuroleptic which is a
potent cataleptogenic drug, was also increased by bicuculline pretreatment. Aflupenthixol,
in animals pretreated with picrotoxin, induced a small but significant
increase in catalepsy.
4- Muscimol catalepsy may be due to GABA inhibitory effect of the drug upon
dopaminergic function, while potentiation of cataleptogenic effect of a-flupenthixol
or that of muscimol by bicuculline may be exerted through release of GABA from
GABAergic nerve endings
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182
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-631&slc_lang=en&sid=1
A
SADEGHI-LOUYEH
20031947532846006172
20031947532846006172
Yes
From the Department of Physiology Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Y
SIMONIAN
20031947532846006173
20031947532846006173
No
From the Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.