Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1372
2
1
gregorian
1993
5
1
7
1
online
1
fulltext
en
THE P REPARATION AND EVALUATION OF REFERENCE LEISHMANIN FROM LEISHMANIA MAJOR FOR USE IN MAN FOR DIAGNOS TIC AND EXPERIMENTAL PURPOSES
Immunology
Immunology
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
Cell-mediated immunity (CMI) plays an important role in resistance against
leishmaniasis. Delayed-type hypersensitivity (DTH) reaction measured by skin
testing is a practical method of evaluation of CMI and is used as an aid to diagnosis
and for epidemiological assessment of exposure to leishmanial infection. Skin
testing in leishmaniasis, generally known as Montenegro or leishmanin test, requires
a standard antigen. At present no uniform and standard leishmanin is available for
skin testing in leishmaniasis. The present work describes the preparation and testing
of an antigen from Leishmania major using standard conditions. Three dilutions of
this antigen were tested in recovered individuals in an endemic area in Iran. The
results obtained showed that leishmanin preparation exhibited high specificity and
sensitivity, and strong potency.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-657&slc_lang=en&sid=1
MOHAMMAD HOSSEIN
ALIMOHAMMADIAN
20031947532846006225
20031947532846006225
Yes
From the Department of Immunology. Pasteur Institute of Iran
HASAN
HAKIMI
20031947532846006226
20031947532846006226
No
the Department of Biochemistry,Pasteur Institute of Iran, Tehran. Islamic Republic of Iran.
MORADALI
NIKSERESHT
20031947532846006227
20031947532846006227
No
From the Department of Immunology. Pasteur Institute of Iran