Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1371
11
1
gregorian
1993
2
1
6
4
online
1
fulltext
en
DIETARY SALT REDUCTION POTENTIATES THE ACTION OF HYPOTENSIVE DRUGS
Epidemiology
Epidemiology
Original Research
Original Research
Hypertension is a common health problem. Hypotensive drugs and low salt diet are used
in its treatment. This study was designed to compare the effectiveness of a low-salt diet and
drug therapy in the treatment of arterial hypertension. A total of 256 randomly selected patients
with essential hypertension consulting the Non-contagious Diseases Clinic in Shahreza,
Isfahan, Iran, were included in the study for a period of 28 days. They were divided into four
groups. Groups A and B received both methyldopa (250 mg t.i.d.) and hydrochlorothiazide
(daily 10 mg), the former consuming a normal and the second a low-salt diet. Groups C and
D consumed a low-salt and a salt-free diet, respectively, with no drugs. Both treatments A and
B caused statistically significant reductions in blood pressure even after seven days, but treatment
B was much more effective. Reductions in blood pressure in Groups C and D were very
little, even after 28 days. Using the three-way classification of analysis of variance, it was revealed
that interactions existed among the three factors, i.e., age, diet and length of treatment,
as regards lowering blood pressure. We conclude, confirming previous reports in the literature,
that a low-salt diet potentiates the hypotensive action of antihypertensive drugs.
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http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-671&slc_lang=en&sid=1
A
DJAZAYERI
20031947532846006251
20031947532846006251
Yes
From the Department of Human Ecology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran
MAHMOOD M.M.
FARAHANI
20031947532846006252
20031947532846006252
No
Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences
H
NAZEM
20031947532846006253
20031947532846006253
No
Department of Nutrition, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.