en Immunology Immunology Original Research Original Research In order to determine the normal values of total IgE in children, 3270 sera were taken from 0-14 year old males and females in different parts of Tehran, the capital of Iran. The technique which was used to measure total IgE was ELISA method using monoclonal anti-IgE antibody. The results of this research indicated that the lower value for IgE was detected in children at birth (X=3.S3 IU/mL), while the highest value was in 10 year old children (X=74.63 IU/mL). Therefore, it has been concluded that with increasing age, the IgE level will also increase (r=0.919). Regardless of the age value, the IgE content in both males and females are the same. But concerning age and sex, the IgE level in four year old girls was higher (X=44.92) than similarly aged boys (X=28.2) (P<0.01), while in eight year old boys, a higher value of IgE (X=66.42) was recorded in comparison to the same aged girls (X=49 .S9) (p<0.05). 269 272 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-672&slc_lang=en&sid=1 R REZAEIPOOR 20031947532846006254 20031947532846006254 Yes From the Department of Immunology, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. HR MOHAMMAD ZADEH 20031947532846006255 20031947532846006255 No