en Biological Sciences Biological Sciences Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine Isotherms of the binding of the anthracycIine antibiotic, adriamycin (adriblastin), to DNA histone complexes was studied by means of spectroscopic analysis. The results indicated that: (a) binding of adriamycin to histones reduced the interaction of histones with DNA, (b) binding of the drug to DNA did not change the binding affinity of histone to DNA and, (c) in the explored binding range of r<O.1 the binding of adriamycin to DNA-histone complex proved to be anticooperative with n values of 0.32 for the interaction of histone with DNA-drug and 0.26 for the binding of DNA to histone-drug complex. The results suggest the possible participation of his tones in the DNA-drug complex formation. Anthracycline, Chromation, Histones, Adriomycin 275 279 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-674&slc_lang=en&sid=1 AZRA RABBANI 20031947532846006259 20031947532846006259 Yes From the Institute of Biochemistry and Biophysics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. MARZIEH HAGSHARIFIA TAGAVI 20031947532846006260 20031947532846006260 No BAHRAM GOLIAEI 20031947532846006261 20031947532846006261 No