en Pharmacology Pharmacology Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine The glucosinolate autolysis products of crushed seeds of DesclIrainia sophia L. (khakeshi) and Brassica napus L. (shelghem) were administered orally to rats in doses representing 8,16 and 32 gm seeds/kg body weight/day at intervals of 10, 20 and sometimes 30 days. Serum T3 and T4 concentrations were reduced in 10 day•autolysate treated animals in a similar fashion to that found with methimazole. The antithyroid effect persisted until day 20, but was weaker than that seen with methimazole. By day 30, serum T3 and T4 concentrations returned to normal in plant treated animals. 165 168 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-785&slc_lang=en&sid=1 SULEIMAN AFSHARYPOUR 20031947532846006559 20031947532846006559 Yes From the Faculty of Pharmacy, and the School of Medicine, Department of Pharmacology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. ALI HAERY 20031947532846006560 20031947532846006560 No