en Medical Basic Sciences Medical Basic Sciences Original Research: Basic Science in Medicine Original Research: Basic Science in Medicine The synthesis of the title compound, bitamycin, by means of BU4NF is described. This new antiviral drug was found to be one of the most powerful and least toxic substances for antiviral therapy in man. The physical and chemical behavior as well as the antiviral activities and clinical properties of this compound were found to be significantly different from that reported by Schaeffer, et al. Although the latter was claimed to have structure 1, we found it to possess structure 2. BU4NF was proved to be an effective reagent for the exclusive preparation of N(9)-alkylated products of purines. Condensation reactions and deprotection of the acyl-protecting groups to yield acyclo - nucleoside analogues were performed in a one step reaction. 57 67 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-797&slc_lang=en&sid=1 G.H HAKIMELAHI 20031947532846006636 20031947532846006636 No F MOHANAZADEH 20031947532846006637 20031947532846006637 No A KHALAFINEZHAD 20031947532846006638 20031947532846006638 Yes From the Department of Chemistry' Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Islamic Republic of Iran. M ZAKERINIA 20031947532846006639 20031947532846006639 No From the Department of Internal Medicine