Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1382
11
1
gregorian
2004
2
1
17
4
online
1
fulltext
en
HIGH-DOSE ORAL PYRIDOXINE FOR TREATMENT OF PEDIATRIC RECURRENT INTRACTABLE SEIZURES
Pediatric
Pediatric
Original Research
Original Research
Intractable epilepsy is a common clinical problem in pediatrics and approximately
13% of children with epilepsy experience intractable seizures. To determine
the efficacy of pyridoxine in treating seizures, 30 infants and children with
recurrent seizures were enrolled in the present study. All of them were treated
with high-dose oral pyridoxine (40 mg/kg/day), as an adjunct to antiepileptic drugs.
Clinical efficacy criteria were based on the daily frequency of seizures after
therapy was initiated during the following three weeks.
The results indicated that the mean frequency of seizures decreased significantly
from the first (16.2±11) to the fourth visit (7±6.2) (p<O.OOl, t=4). Three patients
became completely seizure free. No adverse effects of pyridoxine were apparent
during the observation period.
We conclude that pyridoxine is a safe, effective, and well-tolerated adjunct
to routine antiepileptic drugs for the treatment of recurrent intractable seizures in
children.
Intractable seizure, Pyridoxine, Antiepileptic
301
304
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-810&slc_lang=en&sid=1
JAVAD
AKHOONDIAN
j-akhondian@mums.ac.ir
20031947532846006717
20031947532846006717
Yes
From the Department of Pediatric Neurology, Ghaem General Hospital, Mashhad University of Medical
SAEED
TALEBI
20031947532846006718
20031947532846006718
No
From the Department of Pediatric Neurology, Ghaem General Hospital, Mashhad University of Medical