Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1370
8
1
gregorian
1991
11
1
5
3
online
1
fulltext
en
ANTICONVULSANT THERAPY-INDUCED ALTERATIONS IN CALCIUM HOMEOSTASIS
Pharmacology
Pharmacology
Original Research
Original Research
35 epileptic patients, aged 10 to 58 years (mean 23), who were taking
anticonvulsant drugs were studied. The patients exhibited a 34% reduction
in serum calcium levels, a 41 % increase in serum alkaline phosphatase
activity and a slight but insignificant decrease in serum phosphate, compared
to untreated controls. These changes appear to be related to the anticonvulsant
drug taken, in the following order of decreasing importance: phenytoin
+ phenobarbital + carbamazepine phenytoin + phenobarbital phenytoin
+ carbamazepine,and phenobarbital + carbamazepine. It is possible that
anticonvulsant drugs alter vitamin D metabolism which results in disturbance
of calcium homeostasis. Moreover these changes in serum calcium and
alkaline phosphatase activity in anticonvulsant treatment patients are
similar to those in patients with osteomalacia.
135
137
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-821&slc_lang=en&sid=1
T
GHAFGHAZI
20031947532846006747
20031947532846006747
Yes
From the Departments of Pharmacology and Neurology, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran.
H.R
JAMSHIDI
20031947532846006748
20031947532846006748
No
A
GHORBANI
20031947532846006749
20031947532846006749
No