Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1370
8
1
gregorian
1991
11
1
5
3
online
1
fulltext
en
THE EFFECT OF THEOPHYLLINE ON THE PRODUCTION OF COLONY STIMULATING FACTOR (CSF)BY THE LUNG
Clinical Biochemistry
Clinical Biochemistry
Original Research: Basic Science in Medicine
Original Research: Basic Science in Medicine
The effect of theophylline on colony stimulating factor production by
the lung tissue was investigated. Addition of various concentrations of
theophylline to the lung conditioned medium enhanced CSF production at
10 µg/ml and at higher concentrations showed an inhibitory effect. Determination
of the phosphate content of the medium showed a decrease at 1-3
hours of incubation. Addition of AMP to the cultures in the presence of
theophylline had no effect on the CSF production but compensated phosphate
content of the lung cultures. Exogenous cAMP or its dibutyryl
derivative also stimulated CSF production. On the other hand IBMX,
another inhibitor of phosphodiesterases, exerted similar effect as theophylline.
The results suggest that cAMP regulates CSF production by the lung.
149
154
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-298-824&slc_lang=en&sid=1
A
RABBANI
20031947532846006757
20031947532846006757
Yes
From the Institute of Biochemistry and Biophysics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
M
BOOJAR
20031947532846006758
20031947532846006758
No
B
GOLIAEI
20031947532846006759
20031947532846006759
No