en Medical Genetics Medical Genetics Original Research Original Research <p> <strong>Abstract </strong></p><p> <strong>Background:</strong> Mosaic form of turner syndrome that represented by two or more </p><p> cell lines in an affected individual, often has limitation for detection with classical </p><p> cytogenetic methods. The present study was carried out to compare the efficiency of </p><p> interphase Fluorescence In Situ Hybridisation (FISH) and cytogenetic techniques in </p><p> detection of mosaic form of turner syndrome. </p><p> <strong>Methods:</strong> All candidate samples for turner syndrome were surveyed with both interphase FISH using DXZ1 as a chromosome X specific probe and the GTG- banding methods. The chi square test was used and a P-value of less than 0.05 was considered as being significant. </p><p> <strong>Results:</strong> Asignificant difference was observed between results obtained from the </p><p> application of the two methods under study (P<0.05), indicating that the interphase </p><p> FISH is favourably compares to conventional cytogenetics in detection of mosaic </p><p> form of X chromosome aneuploidy, as an extended number of cells can be scored in a </p><p> limited time. </p><p> <strong>Conclusion:</strong> The results indicate that using the two techniques in parallel allow accurate differentiation between mosaicism and homogenous aneuploidy of X chromosome, and thus both numerical and structural aberrations of the X will be analyzed. </p> Turner syndrome, mosaicism, FISH, clasical cytogenetics 121 125 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-114&slc_lang=en&sid=1 Seyed Mojtaba Mohaddes mohaddesmo@yahoo.com 2003194753284600867 2003194753284600867 Yes Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Shohreh Shargh shohrehshargh@gmail.com 20031947532846001025 20031947532846001025 No Simin Tagavi taghavi220@msn.com 20031947532846001032 20031947532846001032 No