en Otorhinolaryngology Otorhinolaryngology Original Research Original Research <p> <strong> Abstract </strong><strong></strong></p><p> <strong> Objective: </strong>To determine the effect of oral zinc sulfate supplementation given with </p><p>  coamoxiclav when compared with coamoxiclav alone for treatment of otitis media </p><p>  with effusion (OME). The efficacy of the drug was assessed 3 and 6 weeks after administration . </p><p> <strong> Methods: </strong>In a double-blind, randomized trial 4 to 14 years old children with OME </p><p>  who referred to ear, nose and throat clinic, were randomly assigned into two groups : </p><p>  1) Zinc group: Zinc sulfate + Coamoxiclav + Pseudoephedrine + Nacl nasal drop </p><p>  2) Placebo group: Placebo + Coamoxiclav + Pseudoephedrine + Nacl nasal drop . </p><p>  Atotal of 52 children were studied consisting zinc group 29 and placebo group 23 </p><p>  children. Children were examined by otoscopy and tympanometry at entry and after </p><p>  3 weeks of treatment. For children who had not been cured completely after 3 weeks , </p><p>  treatment continued for more 3 weeks (total of 6 weeks ( . </p><p> <strong> Results: </strong>At the end of the first course of treatment (3 weeks) 62.1% of children in </p><p>  the zinc group had clinical improvement compared with 43.5% of children in placebo </p><p>  group. Tympanometrically, 70.9% of children in zinc group had improvement </p><p>  compared with 65.5% for placebo group with no statistically significant difference . </p><p>  There was no significant difference between the two groups at the end of second </p><p>  course of treatment (6 weeks). But the response rate of zinc group was better than the </p><p>  placebo group (43.8% versus 12.5% clinically and 56.3% versus 40% tympanometricall). Zinc administration and cycles of treatment had no significant relationship . </p><p> <strong> Conclusion: </strong>Although in this study oral zinc sulfate supplementation had not significant effect on treatment of OME, the response rate was better in zinc group compared to placebo group specially in longer administration . According to the findings, it seems more studies about oral zinc supplementation </p><p>  in the treatment of OME is needed . </p> supplementation of zinc, otitis media with effusion, tympanometry 126 132 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-115&slc_lang=en&sid=1 Poopak Izadi popakizadi@yahoo.com 20031947532846001417 20031947532846001417 Yes Shahed University, Tehran, Iran Mohammad-ebrahim Yarmohammadi yarmohammadime@yahoo.com 20031947532846001418 20031947532846001418 No Shahed University, Tehran, Iran Nahid Kholdi kholdi_nahid@yahoo.com 20031947532846001419 20031947532846001419 No Shahed University, Tehran, Iran Babak Izadi Bizadi@hotmail.com 20031947532846001420 20031947532846001420 No Kermanshah University, Kermanshah, Iran Sasan Anari A_sassan60@yahoo.com 20031947532846001421 20031947532846001421 No Morteza Sedehi Sedehi56@yahoo.com. 20031947532846001422 20031947532846001422 No Shahed University, Tehran, Iran