Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1389
8
1
gregorian
2010
11
1
24
3
online
1
fulltext
en
Meningeal melanomas associated with transforming Ota nevus to malignant melanoma: a case report
Neurosurgery
Neurosurgery
case report
case report
<p> <strong> Absract </strong></p><p> Intracranial invasion of cellular blue nevus (CBN) from the skin is extremely rare </p><p> and such a condition with malignant transformation is even rarer. A case of </p><p> meningeal melanoma with malignant transformation which was derived from an Ota </p><p> nevus is presented in this report. </p><p> A21-year-old man with a neurocutaneous syndrome since childhood was referred </p><p> with headache and mild left hemiparesia. CT scan and MRI demonstrated intracranial </p><p> lesions and conjunctival biopsy leads to the pathologic diagnosis of blue nevus. </p><p> Thereafter his parietal lesion was operated by craniotomy with total gross excision. </p><p> On histopathological examination, diagnosis of malignant melanoma was confirmed. </p><p> Approximately 2 months after radiotherapy and chemotherapy, he afflicted to </p><p> diplopia and blurred vision on the leftside due to enlargement of orbital and cavernous </p><p> sinus lesion. Following one year follow-up, he was survived and thrived with </p><p> diffuse leptomeningeal nodular enhancement in favor of melanoma dissemination. </p><p> Primary intracranial melanomas are though rare, but it should be suspected especially </p><p> in the presence of periorbital blue nevus or nevus of Ota. Moreover, although CBN </p><p> is considered benign, scalp or periorbital CBN has the potential for intracranial invasion and malignant transformation. </p>
Meningeal Melanomas, Ota nevus, Malignancy
163
168
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-121&slc_lang=en&sid=1
Maziar
Azar
maziarazar@yahoo.com.
2003194753284600783
2003194753284600783
No
Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran
Farid
Kazemi
faridkazemi_2006@yahoo.com.
2003194753284600784
2003194753284600784
No
Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran.
Eshagh
Bahrami
bahrami_eses@yahoo.com.
2003194753284600785
2003194753284600785
No
Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran.
Ebrahim
Hejazian
ebi_hgqi@yahoo.com
2003194753284600786
2003194753284600786
Yes
Department of Neurosurgery, Iran University of Medical Sciences and Health Services
Seyed-Mohammad
Fereshtehnejad
smf681@yahoo.com
2003194753284600787
2003194753284600787
No
Iran University of Medical Sciences and Health Services, Tehran, Iran
Ali
Ahmadi
ahmadi.sayedali @gmail.com
2003194753284600788
2003194753284600788
No
Department of Neurosurgery, Iran University of Medical Sciences and Health Services, Tehran, Iran
Masih
Yasari
my_md55@yahoo.com
2003194753284600789
2003194753284600789
No
Department of Neurosurgery, Iran University of Medical Sciences and Health Services, Tehran, Iran