en Neurosurgery Neurosurgery case report case report <p> <strong> Absract </strong></p><p>  Intracranial invasion of cellular blue nevus (CBN) from the skin is extremely rare </p><p>  and such a condition with malignant transformation is even rarer. A case of </p><p>  meningeal melanoma with malignant transformation which was derived from an Ota </p><p>  nevus is presented in this report. </p><p>  A21-year-old man with a neurocutaneous syndrome since childhood was referred </p><p>  with headache and mild left hemiparesia. CT scan and MRI demonstrated intracranial </p><p>  lesions and conjunctival biopsy leads to the pathologic diagnosis of blue nevus. </p><p>  Thereafter his parietal lesion was operated by craniotomy with total gross excision. </p><p>  On histopathological examination, diagnosis of malignant melanoma was confirmed. </p><p>  Approximately 2 months after radiotherapy and chemotherapy, he afflicted to </p><p>  diplopia and blurred vision on the leftside due to enlargement of orbital and cavernous </p><p>  sinus lesion. Following one year follow-up, he was survived and thrived with </p><p>  diffuse leptomeningeal nodular enhancement in favor of melanoma dissemination. </p><p>  Primary intracranial melanomas are though rare, but it should be suspected especially </p><p>  in the presence of periorbital blue nevus or nevus of Ota. Moreover, although CBN </p><p>  is considered benign, scalp or periorbital CBN has the potential for intracranial invasion and malignant transformation. </p> Meningeal Melanomas, Ota nevus, Malignancy 163 168 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-121&slc_lang=en&sid=1 Maziar Azar maziarazar@yahoo.com. 2003194753284600783 2003194753284600783 No Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran Farid Kazemi faridkazemi_2006@yahoo.com. 2003194753284600784 2003194753284600784 No Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran. Eshagh Bahrami bahrami_eses@yahoo.com. 2003194753284600785 2003194753284600785 No Department of Neurosurgery, Iran University of Medical Sciences and Health Services , Tehran, Iran. Ebrahim Hejazian ebi_hgqi@yahoo.com 2003194753284600786 2003194753284600786 Yes Department of Neurosurgery, Iran University of Medical Sciences and Health Services Seyed-Mohammad Fereshtehnejad smf681@yahoo.com 2003194753284600787 2003194753284600787 No Iran University of Medical Sciences and Health Services, Tehran, Iran Ali Ahmadi ahmadi.sayedali @gmail.com 2003194753284600788 2003194753284600788 No Department of Neurosurgery, Iran University of Medical Sciences and Health Services, Tehran, Iran Masih Yasari my_md55@yahoo.com 2003194753284600789 2003194753284600789 No Department of Neurosurgery, Iran University of Medical Sciences and Health Services, Tehran, Iran