en Pediatric Pediatric Original Research Original Research <font face="Times New Roman" size="3"> </font><p class="MsoNormal" style="margin: 0in 0in 10pt text-align: justify text-justify: inter-ideograph"><font size="3"><font face="Calibri">Harlequin ichthyosis is a rare and the most severe form of congenital ichthyosis. Although prenatal diagnosis is difficult for this disorder, recently, this obstacle has markedly improved with the use of DNA-based prenatal diagnosis. Here in, we presented a neonate with harlequin ichthyosis born by assisted reproductive technology (ART). In this case, the diagnosis of harlequin ichthyosis was not established by conventional prenatal screening.<o:p /></font></font></p><font face="Times New Roman" size="3"> </font> Harlequin ichthyosis, Harlequin fetus, Assisted reproductive technology, Prenatal diagnosis, In vitro fertilization. 229 232 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-601&slc_lang=en&sid=1 Roya Farhadi dr.royafarhadi@gmail.com 20031947532846009015 20031947532846009015 Yes Pediatric department of Booali-Sina Hospital, MazandaranUniversity of Medical science, Sari, Iran. Seyyed Habib Kazemi dr.ss.kazemi@gmail.com 20031947532846009016 20031947532846009016 No Mazandaran University of Medical science, Sari, Iran