Medical Journal of the Islamic Republic Of Iran

en Effect of aerobic exercise and fish oil supplements on plasma levels of inflammatory indexes in mice Physiology Physiology Original Research Original Research Background: Exercise has positive and negative effects on immune system. Herein, we would like to investigate the effects of incremental aerobic training and fish oil supplementation on the plasma levels of CRP, CPK and IL-17 in trained mice. One of the major roles of immune system is to produce soluble or cellular components that provide the immunity against inflammatory agent. The purpose of this study is to investigate distinct and combine effects of incremental aerobic training and fish oil supplement on plasma levels of IL-17, CPK and CRP in trained male mice.<o:p /> Methods: Totally, 54 healthy male mice (2 months old, weight= 34±1 grams) were selected. At first 10 mice were killed to determine base line values, the rest of them were randomly divided into four groups, control group (C, n=11), supplement group (S, n=11), training group (T, n=11) and supplement-training group (ST, n=11).The supplement and supplement-training groups were fed with 0.2cc/day fish oil for 8 weeks. Training and supplement-training groups underwent exercise for 5 sessions per week for a period of 8 weeks on animal treadmill. SPSS 16.0 software and multivariate analysis of variance were used for statistical analysis of data.<o:p /> Results: Exercise and fish oil supplement lead to a decrease in CRP levels and subsequently causing a reduction in plasma levels of IL-17 and CK in mice (p<0.05).<o:p /> Conclusion: Combination of exercise and fish oil can reduce regulate inflammatory response caused by incremental exercise.<o:p /> Fish oil supplement, Inflammation, IL -17, CRP, CPK. 37 44 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-611&slc_lang=en&sid=1 Hamid Alizadeh halizadeh327@gmail.com 200319475328460013027 200319475328460013027 Yes Exercise Physiology Department, Mazandaran University, Mazandaran, Iran. Behzad Bazgir bazgirbehzad@yahoo.com 200319475328460013028 200319475328460013028 No Exercise Physiology Research Center, Baqiyatallah University of Medical Science, Tehran, Iran. Farhad Daryanoosh daryanooshf@yahoo.com 200319475328460013029 200319475328460013029 No Department of Physical Education, Shiraz University, Shiraz, Iran. Maryam Koushki koushki53@yahoo.com 200319475328460013030 200319475328460013030 No Department of Physical Education, Shiraz University, Shiraz, Iran. Vahid Sobhani sobhani515@yahoo.com 200319475328460013031 200319475328460013031 No Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences,Tehran, Iran.