Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Pallidaldeep brain stimulation for the treatment of DYT6 dystonia: a case report and review of literature
Neurology
Neurology
case report
case report
<p> Little is known about the results of pallidal deep brain stimulation (DBS) in DYT6 dystonia. This will be the first report of DYT6 dystonia treated with pallidal DBS from Iran. <a name="OLE_LINK87"></a><a name="OLE_LINK86">A 21 years old male patient with DYT6 dystonia underwent bilateral deep brain stimulation. The target of DBS was the sensorimotor region of the posteroventralglobuspallidusinternus (GPi). DBS parameters included an amplitude of 2.7 V, frequency of 160 Hz, and pulse width of 90 μs which were adjusted according to the patient's response 12 months after surgery. Treatment outcome was measured by the patient’s Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) score<strong>.</strong> </a>Before surgery, the patient's BFMDRSscore was 32. However, BFMDRS score reduced to 7 at one year follow up after surgery(78% improvement of total score). Dystonic symptoms of extremities and mouth completely resolved. Also speech and swallowing function significantly improved. Although previous observations reported a poor to moderate response in speech, we found DBS as an effective treatment not only for dystonic features, but also for speech improvement of DYT6 dystonia. </p>
Deep brain stimulation, DYT6 dystonia, Globus pallidusinternus.
249
251
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-668&slc_lang=en&sid=1
Shahnaz
Miri
shz_miri@yahoo.com
200319475328460012863
200319475328460012863
No
Downstate Medical Center, Brooklyn, NY 11203 – 2098.
Gholam Ali
Shahidi
gshahidi@hotmail.com
200319475328460012864
200319475328460012864
No
Iran University of Medical Sciences, Tehran, Iran.
Mansour
Parvaresh
m_parvaresh@yahoo.com
200319475328460012865
200319475328460012865
No
Iran University of Medical Sciences, Tehran, Iran.
Mohammad
Rohani
mohammadroohani@gmail.com
200319475328460012866
200319475328460012866
Yes
Iran University of Medical Sciences, Tehran, Iran.