Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Human chorionic gonadotrophin as an indicator of persistent ges-tational trophoblastic neoplasia
Gynecology & Obstetrics
Gynecology & Obstetrics
Original Research
Original Research
<p> <strong> Background </strong>: Gestational trophoblastic neoplasia (GTN) disease is excessive and inappropriate proliferation of trophoblast after termination of the pregnancy. Many attempts have been made to improve follow-up procedures, but no studies have evaluated Human Chorionic Gonadotrophin (HCG) as a post treatment indicator. Thus we aimed to know β-HCG variability in post treatment pregnancies. </p><p> <strong> Methods: </strong>40 Molar affected pregnancies were followed post-surgical treatment by serum β-HCG level in a tertiary level hospital. All subjects were treated by evacuation and followed by β-HCG every week for three weeks, then every month for six months. </p><p> <strong> Results: </strong>30 women were normal (group I) and 10 (group II) diagnosed as GTN cases. Serum β-HCG which obtained serially shown significant differences between two groups (p=0.001). The quantity of β-HCG/week had significantly higher level than normal females ( p<0.001) </p><p> <strong> Conclusion: </strong>Our results suggested that β-HCG serum level could be used as a strong indicator for identifying affected patients at early stage. </p><p> </p>
Gestational trophoblastic neoplasia, Molar pregnancy, β-HCG, Chemotherapy.
272
275
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-674&slc_lang=en&sid=1
Soheila
Aminimoghaddam
dr_aminimoghaddam@yahoo.com
200319475328460012842
200319475328460012842
No
Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Fariba
Yarandi
yarandi_f@yahoo.com
200319475328460012843
200319475328460012843
Yes
Tehran University of Medical Sciences, Tehran, Iran.
Forough
Nejadsalami
200319475328460012844
200319475328460012844
No
Iran University of Medical Sciences, Tehran, Iran.
Farrokh
Taftachi
ftaftachi@yahoo.com
200319475328460012845
200319475328460012845
No
Tehran University of Medical Sciences, Tehran, Iran.
Fereshteh
Noorbakhsh
200319475328460012846
200319475328460012846
No
Iran University of Medical Sciences, Tehran, Iran.
Fatemeh
Mahmoudzadeh
200319475328460012847
200319475328460012847
No
Mazandaran University of Medical Ssciences, Sari, Iran.