Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Evaluation of procalcitonin as a biomarker of diagnosis, severity and postoperative complications in adult patients with acute appendicitis
Gastroenterology
Gastroenterology
Original Research
Original Research
<p> <strong> Background </strong>:Delay in diagnosis and treatment of acute appendicitis (AA) results in an increased rate of perforation, postoperative morbidity, mortality and hospital length of stay. Several biochemical parameters including white blood cell (WBC) count, C-reactive protein (CRP), interleukin-6 (IL6) and Procalcitonin (PCT) have been used to further improve the clinical diagnosis of AA. The aim of this study was to assess the value of procalcitonin as a predictor of diagnosis and severity of appendicitis in order to improve the clinical decision making, since other studies have been unable to demonstrate a diagnostic value for PCT elevation in acute appendicitis. </p><p> <strong> Methods: </strong>One-hundred patients who underwent open appendectomy, including 75 men and 25 women with a mean age of 28 years were included in this study. Procalcitonin values were measured by an immunofluorescent method). Serum PCT>0.5 ng/ml was considered positive. The PCT serum values were measured in four different categories, including ˂0.5ng/ml, 0.5-2 ng/ml, 2-10ng/ml and more than 10ng/ml. </p><p> <strong> Results: </strong>The sensitivity and specificity of PCT level measurement for acute appendicitis diagnosis were 44% and 100% respectively. The value of PCT increased with the severity of appendicitis and also with the presence of peritonitis and infection, at the site of surgery. </p><p> <strong> Conclusions: </strong>Procalcitonin measurement cannot be used as a diagnostic test for adult patients with acute appendicitis and its routine use in such patients is not cost effective and conclusive. Procalcitonin values can be used as a prognostic marker and predictor of infectious complications following surgery and it can help to carry out timely surgical intervention which is highly recommended in patients with PCT values more than 0.5ng/ml. </p><p> </p>
Appendicitis, Procalcitonin, Diagnosis, Prognosis.
309
314
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-680&slc_lang=en&sid=1
Mohammad
Vaziri
dr_m_vaziri@yahoo.com
200319475328460012808
200319475328460012808
No
Minimally Invasive Surgery Research center, Iran University of Medical Sciences, Tehran, Iran.
Fahimeh
Ehsanipour
200319475328460012809
200319475328460012809
No
Department of Pediatrics, Iran University of Medical Sciences, Tehran, Iran.
Abdolreza
Pazouki
apazouki@yahoo.com
200319475328460012810
200319475328460012810
No
Minimally Invasive Surgery Research Center, Iran University of Medical Sciences, Tehran, Iran.
Zeinab
Tamannaie
zeinab_tamannaie@yahoo.com
200319475328460012811
200319475328460012811
Yes
Minimally Invasive Surgery Research center, Iran University of Medical Sciences, Tehran, Iran.
Tamannaie4Roohollah
Taghavi
research_center88@yahoo.com
200319475328460012812
200319475328460012812
No
Minimally Invasive Surgery Research center, Iran University of Medical Sciences, Tehran, Iran.
Mohaddese
Pishgahroudsari
mo.pishgah@gmail.com
200319475328460012813
200319475328460012813
No
Minimally Invasive Surgery Research center, Iran University of Medical Sciences, Tehran, Iran.
Fatemeh
Jesmi
fatemehjesmi@yahoo.com
200319475328460012814
200319475328460012814
No
Minimally Invasive Surgery Research center, Iran University of Medical Sciences, Tehran, Iran.
Shahla
Chaichian
shahlachaichian@yahoo.com
200319475328460012815
200319475328460012815
No
Director of Minimally Invasive Techniques Research Center, Islamic Azad University, Tehran Medical Unit, Endometriosis Research Center, Iran University of Medical Sciences, Tehran, Iran.