Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Causality relationships between coagulation factors in type 2 diabetes mellitus: path analysis approach
Endocrinology
Endocrinology
Original Research
Original Research
<p> <b>Background:</b> Type 2 diabetic mellitus patients are amongst the most susceptible groups to vascular abnormalities, which predominantly lead to myocardial disease. The hypercoagulable state has been widely studied by researchers as being the major suspicious mechanism facilitating the consecutive chain of molecular events leading to these complications. However, there is no consensus on the definition of the hypercoagulable state with respect to coagulation quantities, their interrelations and basic factor(s) initiating this pathogenic event, by which the prognosis of myocardial complications could be determined.</p><p> <b>Methods:</b> Path analysis was used to study the interactions between coagulation factors as well as other factors beyond coagulation factors in relation with pathogenic events in both diabetics and healthy subjects. In the present work, coagulation factors of 40 healthy and 40 type 2 diabetics were determined experimentally. The data were then analyzed using SPSS and AMOS software. Multivariate regression analysis was done to draw path diagrams.</p><p> <b>Results:</b> Our results show that FII, as the main cause for hypercoagulable state, is directly induced by FX and FVIII in normal individuals and by FX, FXI, FV and VWF cofactors in diabetic patients.</p><p> <b>Conclusion:</b> In general, our findings showed complicated relationship between coagulation factors and their effects either separately or combined.</p>
Hypercoagulable State, Path analysis, vascular Complication, Myocardial Infarction, Coagulation Factors.
357
365
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-689&slc_lang=en&sid=1
Mohammad Reza
Dayer
mrdayer@scu.ac.ir
200319475328460012766
200319475328460012766
Yes
Department of Biology, Faculty of Science, Shahid Chamran University, Ahvaz, Iran.
Maysam
Mard-Soltani
maysam.mardsoltani@gmail.com
200319475328460012767
200319475328460012767
No
Medical Education Development Center, Dezful University of Medical Sciences, Dezful, Iran.
Mohammad Saaid
Dayer
dayer@modares.ac.ir
200319475328460012768
200319475328460012768
No
Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Sayed Mohammad Reza
Alavi
alavi_m@scu.ac.ir
200319475328460012769
200319475328460012769
No
Department of Statistics, Faculty of Mathematics and Computer Sciences, Shahid Chamran University, Ahvaz, Iran.