en Dermatology Dermatology case report case report <p>  Dowling-Degos disease is a rare sporadic or autosomal dominant pigmentary entity, in which clusters of papules and reticulate macules slowly develop with predominance in flexural regions. This entity is due to mutations in the keratin 5 gene, and is related with other cutaneous disorders. We report the sporadic form of Dowling-Degos disease in an elderly man with multiple seborrheickeratosis in a “Christmas tree” pattern.Worthy of note in this case study is the lesions evolved for over than 30 years. The aim is to describe the association of these keratoses with Dowling-Degos disease in a healthy man. </p><p>  </p> Dowling-Degos disease, Reticular pigment anomaly of flexures, Seborrheic keratosis. 420 422 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-699&slc_lang=en&sid=1 Vitorino Modesto dos Santos vitorinomodesto@gmail.com 200319475328460012719 200319475328460012719 Yes Internal Medicine Department of Armed Forces Hospital (HFA) and Catholic University (UCB), Brasília-DF, Brazil. Nayanne Lays dos Santos Pereira nanalays@hotmail.com 200319475328460012720 200319475328460012720 No Renata Faria Silva rezynha82@hotmail.com 200319475328460012721 200319475328460012721 No Fabio Henrique de Oliveira Silva fabiohenrique_81@yahoo.com.br 200319475328460012722 200319475328460012722 No Internal Medicine Department of HFA. Cacilda Joyce Ferreira da Silva Garcia cacildaroberto@msn.com 200319475328460012723 200319475328460012723 No Pathology Division of HFA. Maria Aparecida Alves de Figueiredo Sousa dramariaalves@gmail.com 200319475328460012724 200319475328460012724 No Dermatology Division of HFA.