Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
The inhibitory effect of Acyclovir loaded nano-niosomes against herpes simplex virus type-1 in cell culture
Virology
Virology
Original Research
Original Research
<p> <strong> Background </strong>:Wide distribution and low half-life of acyclovir has led to a high dose consumption of the drug. Recent studies have shown that encapsulation of acyclovir in nano-carriers can increase effectiveness and decrease its side effects. We investigated the inhibitory effect of acyclovir loaded nano-niosomes against herpes simplex virus type-1 (HSV-1) in cell culture. </p><p> <strong> Methods </strong>: In-vitro cytotoxicity study of empty niosomes (E-N), acyclovir loaded niosomes (ACV-N) and ACV as a free drug against HeLa cell line was performed by MTT assay and the viral titers was tested by TCID50 assay. </p><p> <strong> Results </strong>: The results indicated that a significant higher antiviral activity for acyclovir loaded nano-niosomes of about 3 times in comparison with free drug. </p><p> <strong> Conclusion </strong>: The results of this study revealed ACV-N have a higher antiviral activity compared with free drug it could be a suitable carrier for delivery of acyclovir in the treatment of HSV-1 infections. </p><p> </p>
Nano-niosomes, Herpes simplex virus, Cytotoxicity.
641
645
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-730&slc_lang=en&sid=1
Seyed Hamidreza
Monavari
hrmonavari@yahoo.com
200319475328460013296
200319475328460013296
Yes
Department of Virology, School of Medicine, Iran University of Medical Sciences,Tehran, Iran.
Mohammad Javad
Mirzaeiparsa
mparsa1389@gmail.com
200319475328460013297
200319475328460013297
No
School of Advanced Medical Technologies, Tehran University of Medical Sciences,Tehran, Iran
Bahram
Bolouri
tankbolouri@yahoo.com
200319475328460013298
200319475328460013298
No
School of Advanced Medical Technologies, Iran University of Medical Sciences,Tehran, Iran.
Soltan Ahmed
Ebrahimi
ebrahimi@iums.ac.ir
200319475328460013299
200319475328460013299
No
Department of Pharmacology, School of Medicine, Iran University of Medical Scinces,Tehran, Iran.
Angila
Ataei-pirkooh
gila@inbox.com
200319475328460013300
200319475328460013300
No
Department of Virology, School of Medicine, Iran University of Medical Sciences,Tehran, Iran.