en Endocrinology Endocrinology Original Research Original Research <p> <strong> Background </strong>:Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM). </p><p> <strong> Methods </strong>: From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 <a name="_GoBack"></a>were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5. </p><p> <strong> Results </strong>: The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (pfor trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation withApo- A1(r=0.22, p=0.02). </p><p> <strong> Conclusion </strong>: This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM. </p> Fetuin-A, Apo-A1, Apo-B100, Body Fat Percentage, Insulin Resistance, Type 2 Diabetes. 646 652 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-732&slc_lang=en&sid=1 Farzad Shidfar shidfar.f@iums.ac.ir 200319475328460014766 200319475328460014766 No Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. Mitra Zarrati zarrati_ms@yahoo.com 200319475328460014767 200319475328460014767 No Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. Mohamad Ebrahim Khamseh khamseh.m@iums.ac.ir 200319475328460014768 200319475328460014768 No Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. Neda Haghighat neda.hag@gmail.com 200319475328460014769 200319475328460014769 No Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. Ali Rostami ali.rostami.nut@gmail.com 200319475328460014770 200319475328460014770 No Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran. Hamid Zolfaghari h.z.7025@gmail.com 200319475328460014771 200319475328460014771 Yes Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran.