en Community Medicine Community Medicine Review Article Review Article <p> <strong> Background </strong>:Cell-based therapies can be used to treat neurological diseases and spinal cord injuries. The aim of this study was to assess the clinical outcome of bone marrow derived mononuclear cells (BM-MNCs) transplantation in patients with spinal cord injuries. </p><p> <strong> Method </strong>s: Following a systematic review to detect clinical intervention studies, a meta-analysis was done for pooling data to estimate the outcome of BM-MNCs transplantation. The percentage of the patients with improved ASIA scale from one grade to a higher grade was defined as the main outcome. By considering the study design and outcome measurement, two reviewers independently extracted the data. </p><p> <strong> Result </strong>s: Eight relevant primary studies were found seven qualified studies, with a combined total of 328 patients were assessed by meta-analysis, including 314 ASIA-A, 13 ASIA-B, 94 cervical, 227 thoracic and 60 acute injuries. The percentage of the patients’ improvement was tested by meta-analysis through random and fixed models. The overall percentage of all patients’ improved ASIA scale after a one- year follow-up (95% CIs) was 43 (0.27-0.59). </p><p> <strong> Conclusion </strong>: Data from published trials revealed that encouraging results were achieved by autologous BM-MNCs for the treatment of spinal cord injury. However, the number of clinical trials included in the systematic review was too limited to reach a definite conclusion. More qualified clinical trials with standardized methods are needed to truly justify the outcome of this therapeutic modality in SCI patients. </p><p> <strong> </strong></p> Cell Transplantation, Bone Marrow Derived Mononuclear Cells, Spinal Cord Injury. 735 746 http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-739&slc_lang=en&sid=1 Hamid Reza Aghayan hr.aghayan@gmail.com 200319475328460014140 200319475328460014140 No Compliant Stem Cell Manufacturing Facility, Brain and Spinal Cord Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran. Babak Arjmand b_arjmand@farabi.tums.ac.ir 200319475328460014141 200319475328460014141 No Compliant Stem Cell Manufacturing Facility, Chronic Diseases Research Center, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Mohsen Yaghoubi Mohsenyaq@yahoo.com 200319475328460014142 200319475328460014142 Yes Clinical Knowledge Management Unit, Department of Community Medicine, Iran University of Medical Science, Tehran, Iran. Maziar Moradi-Lakeh moradi_m@iums.ac.ir 200319475328460014143 200319475328460014143 No Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran. Homa Kashani hkashani@razi.tums.ac.ir 200319475328460014144 200319475328460014144 No Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Farhad Shokraneh Farhadshokraneh@gmail.com 200319475328460014145 200319475328460014145 No Cochrane Schizophrenia Group, Institute of Mental Health, a Partnership between the University of Nottingham and Nottinghamshire Healthcare NHS Trust, UK.