Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Sensitivity and specificity of adenosine deaminase in diagnosis of juvenile idiopathic arthritis
Pediatric
Pediatric
Original Research
Original Research
<p> <strong> Background </strong>:Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases in children with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis is made through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (Adenosine Deaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis (RA). Evaluation of sensitivity and specificity of serum ADA level in JIA was another objective. </p><p> <strong> Methods </strong>: The study included 120 children with JIA (mean age= 7.6 ± 4.3 years) and 40 children with RA (mean age= 5.5 ± 3.1 years). The ADA was measured in the active phase of both diseases. </p><p> <strong> Results </strong>: The mean ADA serum level was obtained as 15.8 ± 11.8 U/l in JIA patients and 14.3 ± 7.5 U/l in RA patients. The difference was statistically insignificant (p=0.4). Another finding of this study was the significant specificity (77.5%) of this laboratory parameter for JIA in comparison with its low sensitivity (36.7%). Positive predictive value was 83% and negative predictive value 29%. </p><p> <strong> Conclusion </strong>: Determination of ADA serum levels is a noninvasive reliable and easy biomarker for diagnosis of JIA and it can be used as alternative parameters representing disease activity. </p>
Juvenile idiopathic arthritis, Reactive arthritis, Adenosine deaminase, Chronicarthritis, Children.
747
751
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-740&slc_lang=en&sid=1
Mina
Doudkani-Fard
mina_doudkani_fard.1387@yahoo.com
200319475328460013640
200319475328460013640
No
Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Vahid
Ziaee
ziaee@tums.ac.ir
200319475328460013641
200319475328460013641
Yes
Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences and Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Mohamad-Hassan
Moradinejad
mh.moradinejad@gmail.com
200319475328460013642
200319475328460013642
No
Department of Pediatrics, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
Mojtaba
Sedaghat
sedaghat.dr@gmail.com
200319475328460013643
200319475328460013643
No
Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Iran.
Mohammad-Taghi
Haghi-Ashtiani
ashtiani20@yahoo.com
200319475328460013644
200319475328460013644
No
Department of Pathology, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
Zahra
Ahmadinejad
ahmadiz@tums.ac.ir
200319475328460013645
200319475328460013645
No
Department of Infectious Diseases, Tehran University of Medical Sciences, Tehran, Iran.