Medical Journal of the Islamic Republic Of Iran
مجله پزشکی جمهوری اسلامی ایران
Med J Islam Repub Iran
Medical Sciences
http://mjiri.iums.ac.ir
2
journal2
1016-1430
2251-6840
8
10.18869/mjiri
14
8888
13
en
jalali
1392
10
1
gregorian
2014
1
1
28
1
online
1
fulltext
en
Accuracy of pepsinogens for early diagnosis of atrophic gastritis and gastric cancer in Iranian population
Gastroenterology
Gastroenterology
Original Research
Original Research
<p> <strong> Background: </strong>Currently, non-invasive methods for screening atrophic gastritis and gastric cancer are lacking. The purpose of this study was to evaluate the value of serological parameters including serum pepsinogen I (PGI), pepsinogen II (PGII) and pepsinogen I: II ratio for the screening atrophic gastritis and gastric cancer. </p><p> <strong> Methods </strong>: The study population consisted of 132 dyspeptic patients who had undergone upper endoscopy with biopsy. Blood samples for ELISA assays of serum PGI, PGII and IgG antibodies against Helicobacter pylori were drawn. Comparison between the two groups was done by Student’s t- test, and Mann Whitney test. Cut-off points were calculated using receiver operating curves (ROC). </p><p> <strong> Results </strong>: Mean (±SD) age of the study population was 51.4 (±15.5) years. Values of PGI and PG ratio decreased significantly in the atrophic gastritis as compared with the control group (p<0.05). Values of PG and PG ratio didn’t show any significant difference between the gastric cancer and control group (p>0.05). For patients with atrophic gastritis, the area under the ROC for PGI was 0.639 (95% CI:0.538-0.741, p=0.008) in which the best cut-off value was 40μg/L (sensitivity 90%, specificity 67%, accuracy 69%, negative predictive value 92%, YI : 0.429). The area under the ROC for PG ratio was 0.711 (95% CI: 0.617–0.806, p=0.0001) and the best cut-off value was 8 (sensitivity 71%, specificity 71%, accuracy 71%, negative predictive value 86%,YI : 0.431). </p><p> <strong> Conclusion </strong>: It seems that PGI, PGI: PGII ratio is potential biomarkers for screening atrophic gastritis with high sensitivity, specificity, accuracy and negative predictive value. Serology could be used as a screening method for the detection of precancerous states due to its convenience, relative low cost and safety. </p>
Pepsinogens, Atrophic gastritis, Gastric cancer, Biomarkers.
1009
1015
http://mjiri.iums.ac.ir/browse.php?a_code=A-10-1-761&slc_lang=en&sid=1
Abbas
Zoalfaghari
abaszoalfaghari1354@yahoo.com
200319475328460014466
200319475328460014466
Yes
Imam Khomeini hospital, Department of Internal Medicine, Division of Gastroenterology, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran.
Najmeh
Aletaha
aletaha@ddrc.ac.ir
200319475328460014467
200319475328460014467
No
Department of Internal Medicine, Division of gastroenterology, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran.
Nader
Roushan
nroshan@tums.ac.ir
200319475328460014468
200319475328460014468
No
Department of Internal Medicine, Division of gastroenterology, Imam Khomeini hospital, Tehran University of Medical Sciences, Tehran, Iran.
Reza
Taslimi
rtaslimi@tums.ac.ir
200319475328460014469
200319475328460014469
No
Department of Internal Medicine, Division of gastroenterology, Tehran University of Medical Sciences, Tehran, Iran.
Hossein
Foroutan
froutan@ams.ac.ir
200319475328460014470
200319475328460014470
No
Department of Internal Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Bita
Faridnia
B.faridnia@yahoo.com
200319475328460014471
200319475328460014471
No
Tehran, Iran